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EGFL7 EGF like domain multiple 7 [ Homo sapiens (human) ]

Gene ID: 51162, updated on 28-Oct-2018

Summary

Official Symbol
EGFL7provided by HGNC
Official Full Name
EGF like domain multiple 7provided by HGNC
Primary source
HGNC:HGNC:20594
See related
Ensembl:ENSG00000172889 MIM:608582; Vega:OTTHUMG00000020938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEU1; ZNEU1; VE-STATIN
Summary
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Expression
Broad expression in placenta (RPKM 22.8), fat (RPKM 14.4) and 19 other tissues See more
Orthologs

Genomic context

See EGFL7 in Genome Data Viewer
Location:
9q34.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (136654753..136672678)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139553308..139567130)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376325 Neighboring gene uncharacterized LOC102724193 Neighboring gene uncharacterized LOC101928612 Neighboring gene microRNA 126 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene divergent protein kinase domain 1B Neighboring gene small nucleolar RNA host gene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with EGFL7; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC111117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
extracellular matrix HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epidermal growth factor-like protein 7
Names
EGF-like protein 7
NOTCH4-like protein
multiple EGF-like domains protein 7
multiple epidermal growth factor-like domains protein 7
vascular endothelial statin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016215.4NP_057299.1  epidermal growth factor-like protein 7 precursor

    See identical proteins and their annotated locations for NP_057299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL512735, AL590226, AY358902, BI770335
    Consensus CDS
    CCDS7002.1
    UniProtKB/Swiss-Prot
    Q9UHF1
    UniProtKB/TrEMBL
    A0A024R8F5
    Related
    ENSP00000307843.7, ENST00000308874.11
    Conserved Domains (3) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_201446.2NP_958854.1  epidermal growth factor-like protein 7 precursor

    See identical proteins and their annotated locations for NP_958854.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL512735, AL590226, BC012377, BM919940
    Consensus CDS
    CCDS7002.1
    UniProtKB/Swiss-Prot
    Q9UHF1
    UniProtKB/TrEMBL
    A0A024R8F5
    Related
    ENSP00000360763.3, OTTHUMP00000022599, ENST00000371698.3, OTTHUMT00000055096
    Conserved Domains (3) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. NR_045110.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL590226, BC088371, BI770335
  2. NR_045111.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL512735, AL590226, AY358903, BI770335
  3. NR_046367.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF186111, AK091964, AL512735, AL590226, CB047042

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    136654753..136672678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518766.1XP_011517068.1  epidermal growth factor-like protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011517068.1

    UniProtKB/Swiss-Prot
    Q9UHF1
    UniProtKB/TrEMBL
    A0A024R8F5
    Conserved Domains (3) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_017014799.1XP_016870288.1  epidermal growth factor-like protein 7 isoform X5

    Conserved Domains (2) summary
    cd00054
    Location:5277
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:83118
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. XM_017014798.1XP_016870287.1  epidermal growth factor-like protein 7 isoform X5

    Conserved Domains (2) summary
    cd00054
    Location:5277
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:83118
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  4. XM_011518764.1XP_011517066.1  epidermal growth factor-like protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011517066.1

    UniProtKB/Swiss-Prot
    Q9UHF1
    UniProtKB/TrEMBL
    A0A024R8F5
    Related
    ENSP00000360764.1, OTTHUMP00000022597, ENST00000371699.5, OTTHUMT00000055094
    Conserved Domains (3) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  5. XM_017014797.1XP_016870286.1  epidermal growth factor-like protein 7 isoform X4

    Conserved Domains (2) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
  6. XM_017014795.1XP_016870284.1  epidermal growth factor-like protein 7 isoform X2

  7. XM_011518765.1XP_011517067.1  epidermal growth factor-like protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011517067.1

    UniProtKB/Swiss-Prot
    Q9UHF1
    UniProtKB/TrEMBL
    A0A024R8F5
    Conserved Domains (3) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain
    pfam14670
    Location:141176
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  8. XM_017014796.1XP_016870285.1  epidermal growth factor-like protein 7 isoform X3

  9. XM_011518767.1XP_011517069.1  epidermal growth factor-like protein 7 isoform X5

    See identical proteins and their annotated locations for XP_011517069.1

    Conserved Domains (2) summary
    cd00054
    Location:5277
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:83118
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  10. XM_011518768.1XP_011517070.1  epidermal growth factor-like protein 7 isoform X5

    See identical proteins and their annotated locations for XP_011517070.1

    Conserved Domains (2) summary
    cd00054
    Location:5277
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:83118
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  11. XM_006717141.3XP_006717204.1  epidermal growth factor-like protein 7 isoform X4

    Conserved Domains (2) summary
    cd00054
    Location:110135
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07546
    Location:4093
    EMI; EMI domain

RNA

  1. XR_002956789.1 RNA Sequence

  2. XR_002956790.1 RNA Sequence

  3. XR_001746317.1 RNA Sequence

  4. XR_001746319.1 RNA Sequence

  5. XR_001746320.1 RNA Sequence

  6. XR_002956791.1 RNA Sequence

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