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IRAK4 interleukin 1 receptor associated kinase 4 [ Homo sapiens (human) ]

Gene ID: 51135, updated on 2-Nov-2024

Summary

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Official Symbol
IRAK4provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 4provided by HGNC
Primary source
HGNC:HGNC:17967
See related
Ensembl:ENSG00000198001 MIM:606883; AllianceGenome:HGNC:17967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPD1; IMD67; REN64; IRAK-4; NY-REN-64
Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in lymph node (RPKM 7.4), appendix (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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See IRAK4 in Genome Data Viewer
Location:
12q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (43758951..43789541)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (43717649..43748266)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (44152754..44183344)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:44079381-44080176 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6219 Neighboring gene pseudouridine synthase 7 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4372 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:44230125-44230357 Neighboring gene transmembrane protein 117 Neighboring gene MPRA-validated peak1704 silencer Neighboring gene twinfilin actin binding protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr12:44293209-44293937 Neighboring gene MPRA-validated peak1705 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:44318495-44319694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:44373209-44373840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6220 Neighboring gene zinc finger protein 75B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. Medvedev AE, et al. J Immunol, 2005 Jun 1. PMID 15905496
  2. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. Ku CL, et al. J Exp Med, 2007 Oct 1. PMID 17893200, Free PMC Article
  3. Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease. Candan G, et al. Turk J Med Sci, 2019 Apr 18. PMID 30997787, Free PMC Article
  4. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). Wang L, et al. J Biol Chem, 2019 Mar 22. PMID 30679311, Free PMC Article
  5. Functional Polymorphisms in IRAKs Are Related to Hepatocellular Carcinoma Risk in Chinese Population. Wang H, et al. Biomed Res Int, 2018. PMID 30112356, Free PMC Article

See all (185) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension.
    Title: Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension.
  2. Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4.
    Title: Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4.
  3. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
    Title: Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
  4. Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.
    Title: Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.
  5. Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency.
    Title: Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency.
  6. IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
    Title: IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
  7. Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children.
    Title: Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children.
  8. IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants.
    Title: IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants.
  9. Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
    Title: Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
  10. Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance.
    Title: Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance.
Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 67
MedGen: C1843256 OMIM: 607676 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in interleukin-33-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neutrophil migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor 4 signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
  
involved_in toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of plasma membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-associated kinase 4
Names
renal carcinoma antigen NY-REN-64
NP_001107654.1
NP_001138728.1
NP_001138729.1
NP_001138730.1
NP_001338267.1
NP_001338268.1
NP_001338269.1
NP_001338270.1
NP_001338271.1
NP_001338272.1
NP_001338273.1
NP_001338274.1
NP_057207.2
XP_005269000.1
XP_005269001.1
XP_005269002.1
XP_006719501.1
XP_011536733.1
XP_016874879.1
XP_054228149.1
XP_054228150.1
XP_054228151.1
XP_054228152.1
XP_054228153.1
XP_054228154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009892.1 RefSeqGene

    Range
    5001..35600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_75

mRNA and Protein(s)

  1. NM_001114182.3 → NP_001107654.1  interleukin-1 receptor-associated kinase 4 isoform a

    See identical proteins and their annotated locations for NP_001107654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 13 all encode the same isoform (a).
    Source sequence(s)
    AC093012, AI126481, AK304583, AY340963
    Consensus CDS
    CCDS8744.1
    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Related
    ENSP00000446490.1, ENST00000551736.5
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. NM_001145256.2 → NP_001138728.1  interleukin-1 receptor-associated kinase 4 isoform b

    See identical proteins and their annotated locations for NP_001138728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).
    Source sequence(s)
    AC093012, AI126481, AK304583, AY340965
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. NM_001145257.2 → NP_001138729.1  interleukin-1 receptor-associated kinase 4 isoform b

    See identical proteins and their annotated locations for NP_001138729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).
    Source sequence(s)
    AC093012, AI126481, AK299944
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. NM_001145258.2 → NP_001138730.1  interleukin-1 receptor-associated kinase 4 isoform b

    See identical proteins and their annotated locations for NP_001138730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).
    Source sequence(s)
    AC093012, AI126481, AK304583
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Related
    ENSP00000408734.2, ENST00000440781.6
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. NM_001351338.2 → NP_001338267.1  interleukin-1 receptor-associated kinase 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 3-5 and 7-10, encodes isoform b.
    Source sequence(s)
    AC093012, AK027301
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. NM_001351339.2 → NP_001338268.1  interleukin-1 receptor-associated kinase 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 3-6 and 8-10, encodes isoform b.
    Source sequence(s)
    AC093012, AY340967
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  7. NM_001351340.2 → NP_001338269.1  interleukin-1 receptor-associated kinase 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 3-7, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC093012
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  8. NM_001351341.2 → NP_001338270.1  interleukin-1 receptor-associated kinase 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 3-8 and 10, encodes isoform b.
    Source sequence(s)
    AC093012
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  9. NM_001351342.2 → NP_001338271.1  interleukin-1 receptor-associated kinase 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 3-9, encodes isoform b.
    Source sequence(s)
    AC093012
    Consensus CDS
    CCDS44862.1
    UniProtKB/TrEMBL
    B4E359
    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  10. NM_001351343.2 → NP_001338272.1  interleukin-1 receptor-associated kinase 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform c.
    Source sequence(s)
    AC093012
    Conserved Domains (1) summary
    cl21453
    Location:12 → 254
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001351344.2 → NP_001338273.1  interleukin-1 receptor-associated kinase 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform c.
    Source sequence(s)
    AC093012
    Conserved Domains (1) summary
    cl21453
    Location:12 → 254
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001351345.2 → NP_001338274.1  interleukin-1 receptor-associated kinase 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC093012
    Consensus CDS
    CCDS8744.1
    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  13. NM_016123.4 → NP_057207.2  interleukin-1 receptor-associated kinase 4 isoform a

    See identical proteins and their annotated locations for NP_057207.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 13 all encode the same isoform (a).
    Source sequence(s)
    AC093012, AI126481, AK304583, AK314288, BC013316
    Consensus CDS
    CCDS8744.1
    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Related
    ENSP00000479889.3, ENST00000613694.5
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    43758951..43789541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538431.3 → XP_011536733.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011536733.1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. XM_006719438.4 → XP_006719501.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_006719501.1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. XM_005268945.5 → XP_005269002.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005269002.1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. XM_005268943.4 → XP_005269000.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005269000.1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. XM_017019390.3 → XP_016874879.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. XM_005268944.5 → XP_005269001.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005269001.1

    UniProtKB/Swiss-Prot
    Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589
    UniProtKB/TrEMBL
    B2RAP9, Q69FE3
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    43717649..43748266
    Download
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mRNA and Protein(s)

  1. XM_054372174.1 → XP_054228149.1  interleukin-1 receptor-associated kinase 4 isoform X1

  2. XM_054372177.1 → XP_054228152.1  interleukin-1 receptor-associated kinase 4 isoform X1

  3. XM_054372176.1 → XP_054228151.1  interleukin-1 receptor-associated kinase 4 isoform X1

  4. XM_054372178.1 → XP_054228153.1  interleukin-1 receptor-associated kinase 4 isoform X1

  5. XM_054372175.1 → XP_054228150.1  interleukin-1 receptor-associated kinase 4 isoform X1

  6. XM_054372179.1 → XP_054228154.1  interleukin-1 receptor-associated kinase 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWZ3.1 GenPept UniProtKB/Swiss-Prot:Q9NWZ3

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