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MRPS16 mitochondrial ribosomal protein S16 [ Homo sapiens (human) ]

Gene ID: 51021, updated on 5-Jul-2020

Summary

Official Symbol
MRPS16provided by HGNC
Official Full Name
mitochondrial ribosomal protein S16provided by HGNC
Primary source
HGNC:HGNC:14048
See related
Ensembl:ENSG00000182180 MIM:609204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COXPD2; RPMS16; CGI-132; MRP-S16
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 15.2), heart (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See MRPS16 in Genome Data Viewer
Location:
10q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73248849..73252644, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75008601..75012451, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 149 member B1 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2 Neighboring gene DNAJC9 antisense RNA 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene cilia and flagella associated protein 70 Neighboring gene RNA, U6 small nuclear 833, pseudogene Neighboring gene annexin A7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22062, FLJ40972

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S16, mitochondrial
Names
S16mt
mitochondrial small ribosomal subunit protein bS16m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008096.1 RefSeqGene

    Range
    5050..8845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016065.4NP_057149.1  28S ribosomal protein S16, mitochondrial

    See identical proteins and their annotated locations for NP_057149.1

    Status: REVIEWED

    Source sequence(s)
    AC016394, AK025715, BQ441549
    Consensus CDS
    CCDS7323.1
    UniProtKB/Swiss-Prot
    Q9Y3D3
    Related
    ENSP00000362036.3, ENST00000372945.8
    Conserved Domains (1) summary
    TIGR00002
    Location:1797
    S16; ribosomal protein S16

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73248849..73252644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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