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MRPS16 mitochondrial ribosomal protein S16 [ Homo sapiens (human) ]

Gene ID: 51021, updated on 19-Sep-2024

Summary

Official Symbol
MRPS16provided by HGNC
Official Full Name
mitochondrial ribosomal protein S16provided by HGNC
Primary source
HGNC:HGNC:14048
See related
Ensembl:ENSG00000182180 MIM:609204; AllianceGenome:HGNC:14048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S16mt; bS16m; COXPD2; RPMS16; CGI-132; MRP-S16
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 15.2), heart (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

See MRPS16 in Genome Data Viewer
Location:
10q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73248849..73252644, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74120230..74124025, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75008607..75012402, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 149 member B1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:74965967-74966502 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75006455-75007654 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:75012121-75012688 Neighboring gene DNAJC9 and MRPS16 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75015484-75015659 Neighboring gene cilia and flagella associated protein 70 Neighboring gene RNA, U6 small nuclear 833, pseudogene Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22062, FLJ40972

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
small ribosomal subunit protein bS16m
Names
28S ribosomal protein S16, mitochondrial
mitochondrial small ribosomal subunit protein bS16m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008096.1 RefSeqGene

    Range
    5050..8845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001410935.1NP_001397864.1  small ribosomal subunit protein bS16m isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC016394
    Consensus CDS
    CCDS91261.1
    UniProtKB/TrEMBL
    A6ND22
    Related
    ENSP00000362031.3, ENST00000372940.3
  2. NM_016065.4NP_057149.1  small ribosomal subunit protein bS16m isoform 1

    See identical proteins and their annotated locations for NP_057149.1

    Status: REVIEWED

    Source sequence(s)
    AC016394, AK025715, BQ441549
    Consensus CDS
    CCDS7323.1
    UniProtKB/Swiss-Prot
    B4E032, Q96Q60, Q9Y3D3
    Related
    ENSP00000362036.3, ENST00000372945.8
    Conserved Domains (1) summary
    TIGR00002
    Location:1797
    S16; ribosomal protein S16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73248849..73252644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425263.1XP_047281219.1  small ribosomal subunit protein bS16m isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74120230..74124025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365976.1XP_054221951.1  small ribosomal subunit protein bS16m isoform X1