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SLC35B3 solute carrier family 35 member B3 [ Homo sapiens (human) ]

Gene ID: 51000, updated on 13-Mar-2020

Summary

Official Symbol
SLC35B3provided by HGNC
Official Full Name
solute carrier family 35 member B3provided by HGNC
Primary source
HGNC:HGNC:21601
See related
Ensembl:ENSG00000124786 MIM:610845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-19; PAPST2; C6orf196
Summary
This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in colon (RPKM 11.6), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See SLC35B3 in Genome Data Viewer
Location:
6p24.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (8411435..8435567, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (8413301..8435794, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374911 Neighboring gene uncharacterized LOC105374912 Neighboring gene uncharacterized LOC100506207 Neighboring gene hepatocellular carcinoma up-regulated long non-coding RNA Neighboring gene uncharacterized LOC112267952

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 2
Names
3' phosphoadenosine 5' phosphosulfate transporter 2
PAPS transporter 2
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142540.1NP_001136012.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC006973, BX647208, DC357624
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  2. NM_001142541.2NP_001136013.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001136013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK313522, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    Q9H1N7
    UniProtKB/TrEMBL
    A0A024R008, B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  3. NM_001370476.2NP_001357405.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Related
    ENSP00000496368.1, ENST00000644923.1
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  4. NM_001370477.1NP_001357406.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Conserved Domains (1) summary
    pfam08449
    Location:48308
    UAA; UAA transporter family
  5. NM_001370478.2NP_001357407.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
    Source sequence(s)
    AL355815
    Related
    ENSP00000498054.1, ENST00000648987.1
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  6. NM_001370479.1NP_001357408.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
    Source sequence(s)
    AL355815
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  7. NM_015948.4NP_057032.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_057032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK303940, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    Q9H1N7
    UniProtKB/TrEMBL
    A0A024R008, B4E1Q6
    Related
    ENSP00000368981.4, ENST00000379660.4
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family

RNA

  1. NR_109913.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303940, AK313522, BX538271, DB188586, DB576665
    Related
    ENST00000648867.1
  2. NR_109914.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BX647208, DB188586, DB576665
  3. NR_163441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815
  4. NR_163442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    8411435..8435567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010912.2XP_016866401.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

  2. XM_011514648.1XP_011512950.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    See identical proteins and their annotated locations for XP_011512950.1

    UniProtKB/TrEMBL
    A0A024QZW4
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  3. XM_006715103.3XP_006715166.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    Conserved Domains (1) summary
    pfam08449
    Location:82342
    UAA; UAA transporter family
  4. XM_017010913.1XP_016866402.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

  5. XM_017010910.1XP_016866399.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9H1N7
    UniProtKB/TrEMBL
    A0A024R008
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  6. XM_017010914.1XP_016866403.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    UniProtKB/TrEMBL
    A0A024QZW4
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  7. XM_017010911.1XP_016866400.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9H1N7
    UniProtKB/TrEMBL
    A0A024R008
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  8. XM_011514650.2XP_011512952.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

    Conserved Domains (1) summary
    pfam08449
    Location:82245
    UAA; UAA transporter family

RNA

  1. XR_001743451.1 RNA Sequence

  2. XR_001743449.1 RNA Sequence

    Related
    ENST00000649788.1
  3. XR_001743448.1 RNA Sequence

  4. XR_001743446.1 RNA Sequence

  5. XR_002956285.1 RNA Sequence

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