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SLC35B3 solute carrier family 35 member B3 [ Homo sapiens (human) ]

Gene ID: 51000, updated on 24-Nov-2022

Summary

Official Symbol
SLC35B3provided by HGNC
Official Full Name
solute carrier family 35 member B3provided by HGNC
Primary source
HGNC:HGNC:21601
See related
Ensembl:ENSG00000124786 MIM:610845; AllianceGenome:HGNC:21601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-19; PAPST2; C6orf196
Summary
This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in colon (RPKM 11.6), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

See SLC35B3 in Genome Data Viewer
Location:
6p24.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (8411435..8435567, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (8280719..8304851, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (8411668..8435800, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374910 Neighboring gene uncharacterized LOC105374911 Neighboring gene uncharacterized LOC100506207 Neighboring gene hepatocellular carcinoma up-regulated long non-coding RNA Neighboring gene uncharacterized LOC112267952

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 2
Names
3' phosphoadenosine 5' phosphosulfate transporter 2
PAPS transporter 2
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142540.2NP_001136012.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL355815, BC006973, BX647208, DC357624
    UniProtKB/Swiss-Prot
    Q9Y308
    UniProtKB/TrEMBL
    A0A024R008
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  2. NM_001142541.3NP_001136013.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001136013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK313522, AL355815, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    A0A024R008, B2R8V5
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  3. NM_001370476.2NP_001357405.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    Q9Y308
    UniProtKB/TrEMBL
    A0A024R008
    Related
    ENSP00000496368.1, ENST00000644923.2
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  4. NM_001370477.1NP_001357406.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Conserved Domains (1) summary
    pfam08449
    Location:48308
    UAA; UAA transporter family
  5. NM_001370478.2NP_001357407.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS93854.1
    UniProtKB/TrEMBL
    A0A024QZW4
    Related
    ENSP00000498054.1, ENST00000648987.1
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  6. NM_001370479.2NP_001357408.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
    Source sequence(s)
    AL355815
    Consensus CDS
    CCDS93854.1
    UniProtKB/TrEMBL
    A0A024QZW4
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  7. NM_015948.5NP_057032.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_057032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK303940, AL355815, BC006973, BX538271, DB188586, DB576665
    Consensus CDS
    CCDS4508.1
    UniProtKB/Swiss-Prot
    Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    A0A024R008, B4E1Q6
    Related
    ENSP00000368981.4, ENST00000379660.4
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family

RNA

  1. NR_109913.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303940, AK313522, AL355815, BX538271, DB188586, DB576665
  2. NR_109914.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL355815, BX647208, DB188586, DB576665
  3. NR_163441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815
    Related
    ENST00000648867.1
  4. NR_163442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355815

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    8411435..8435567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010912.3XP_016866401.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

  2. XM_011514648.2XP_011512950.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    See identical proteins and their annotated locations for XP_011512950.1

    UniProtKB/TrEMBL
    A0A024QZW4
    Conserved Domains (1) summary
    pfam08449
    Location:48339
    UAA; UAA transporter family
  3. XM_047418848.1XP_047274804.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X9

  4. XM_047418842.1XP_047274798.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4
  5. XM_047418844.1XP_047274800.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4
  6. XM_006715103.4XP_006715166.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

    Conserved Domains (1) summary
    pfam08449
    Location:82342
    UAA; UAA transporter family
  7. XM_047418845.1XP_047274801.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4
  8. XM_047418841.1XP_047274797.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

  9. XM_047418840.1XP_047274796.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1

  10. XM_017010913.2XP_016866402.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

  11. XM_017010910.2XP_016866399.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    A0A024R008
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  12. XM_017010911.2XP_016866400.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9H1N7, Q9Y308
    UniProtKB/TrEMBL
    A0A024R008
    Conserved Domains (1) summary
    pfam08449
    Location:80371
    UAA; UAA transporter family
  13. XM_047418843.1XP_047274799.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

    UniProtKB/TrEMBL
    A0A024QZW4
  14. XM_047418846.1XP_047274802.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

  15. XM_047418847.1XP_047274803.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X8

  16. XM_047418849.1XP_047274805.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X10

RNA

  1. XR_007059268.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    8280719..8304851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)