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Slc35b3 solute carrier family 35, member B3 [ Mus musculus (house mouse) ]

Gene ID: 108652, updated on 2-Nov-2024

Summary

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Official Symbol
Slc35b3provided by MGI
Official Full Name
solute carrier family 35, member B3provided by MGI
Primary source
MGI:MGI:1913978
See related
Ensembl:ENSMUSG00000021432 AllianceGenome:MGI:1913978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-19; PABST2; PAPST2; 4921526O06Rik
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 5'-adenylyl sulfate transmembrane transport and peptidyl-tyrosine sulfation. Located in mitochondrion. Is active in Golgi membrane and trans-Golgi network. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SLC35B3 (solute carrier family 35 member B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 7.6), limb E14.5 (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35b3 in Genome Data Viewer
Location:
13 A3.3; 13 18.61 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (39116112..39144855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38932132..38960879, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34252 Neighboring gene DNA polymerase epsilon subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34253 Neighboring gene STARR-seq mESC enhancer starr_34254 Neighboring gene STARR-seq mESC enhancer starr_34255 Neighboring gene STARR-seq mESC enhancer starr_34256 Neighboring gene predicted gene, 46392 Neighboring gene RIKEN cDNA 5033403F01 gene Neighboring gene STARR-seq mESC enhancer starr_34258 Neighboring gene STARR-seq mESC enhancer starr_34259 Neighboring gene STARR-seq mESC enhancer starr_34260 Neighboring gene STARR-seq mESC enhancer starr_34261 Neighboring gene STARR-seq mESC enhancer starr_34262 Neighboring gene predicted gene 3509 Neighboring gene STARR-seq mESC enhancer starr_34265 Neighboring gene predicted gene, 32243

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells. Sasaki N, et al. PLoS One, 2009 Dec 11. PMID 20011239, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2]
    Title: The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5'-adenylyl sulfate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine sulfation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenosine 3'-phospho 5'-phosphosulfate transporter 2
Names
PAPS transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170430.2 → NP_001163901.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_001163901.1

    Status: VALIDATED

    Source sequence(s)
    AC125223
    Consensus CDS
    CCDS26466.1
    UniProtKB/Swiss-Prot
    Q922Q5
    UniProtKB/TrEMBL
    F8WGD7
    Related
    ENSMUSP00000126016.2, ENSMUST00000167513.3
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

  2. NM_001170431.3 → NP_001163902.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125223
    Consensus CDS
    CCDS26466.1
    UniProtKB/Swiss-Prot
    Q922Q5
    UniProtKB/TrEMBL
    F8WGD7
    Related
    ENSMUSP00000021870.5, ENSMUST00000021870.12
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

  3. NM_001403012.1 → NP_001389941.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125223

  4. NM_001403013.1 → NP_001389942.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125223

  5. NM_001403014.1 → NP_001389943.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125223

  6. NM_001403015.1 → NP_001389944.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125223

  7. NM_001403016.1 → NP_001389945.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125223
    UniProtKB/Swiss-Prot
    Q922Q5

  8. NM_001403017.1 → NP_001389946.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125223

  9. NM_134060.5 → NP_598821.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_598821.1

    Status: VALIDATED

    Source sequence(s)
    AC125223
    Consensus CDS
    CCDS26466.1
    UniProtKB/Swiss-Prot
    Q922Q5
    UniProtKB/TrEMBL
    F8WGD7
    Related
    ENSMUSP00000153046.2, ENSMUST00000225432.2
    Conserved Domains (1) summary
    pfam08449
    Location:48 → 339
    UAA; UAA transporter family

RNA

  1. NR_175328.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125223

  2. NR_175329.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125223

  3. NR_175330.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125223

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    39116112..39144855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247124.1 → XP_030102984.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    Conserved Domains (1) summary
    pfam08449
    Location:92 → 161
    UAA; UAA transporter family

RNA

  1. XR_003950408.2 RNA Sequence

  2. XR_001780746.3 RNA Sequence

  3. XR_004937924.1 RNA Sequence

  4. XR_001780745.3 RNA Sequence

  5. XR_004937925.1 RNA Sequence

  6. XR_003950410.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Q5.1 GenPept UniProtKB/Swiss-Prot:Q922Q5

Gene LinkOut

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