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Nasp nuclear autoantigenic sperm protein (histone-binding) [ Mus musculus (house mouse) ]

Gene ID: 50927, updated on 26-Sep-2022

Summary

Official Symbol
Naspprovided by MGI
Official Full Name
nuclear autoantigenic sperm protein (histone-binding)provided by MGI
Primary source
MGI:MGI:1355328
See related
Ensembl:ENSMUSG00000028693 AllianceGenome:MGI:1355328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epcs32; Nasp-T; D4Ertd767e; 5033430J04Rik
Summary
Enables histone binding activity. Involved in G1/S transition of mitotic cell cycle; blastocyst development; and histone exchange. Acts upstream of or within DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; extraembryonic component; lung; metanephros; and rest of cerebellum marginal layer. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 97.7), testis adult (RPKM 45.2) and 8 other tissues See more
Orthologs
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Genomic context

See Nasp in Genome Data Viewer
Location:
4 D1; 4 53.24 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116458249..116488894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116601052..116628676, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene RIKEN cDNA C530005A16 gene Neighboring gene coiled-coil domain containing 17 Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene predicted gene, 25137

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear autoantigenic sperm protein
Names
somatic histone binding protein NASP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081475.1NP_001074944.1  nuclear autoantigenic sperm protein isoform 1

    See identical proteins and their annotated locations for NP_001074944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 2. It encodes isoform 1, which is shorter than isoform 2.
    Source sequence(s)
    AK083333, AL669953
    Consensus CDS
    CCDS38852.1
    UniProtKB/Swiss-Prot
    Q99MD9
    UniProtKB/TrEMBL
    B1AU76
    Related
    ENSMUSP00000030457.6, ENSMUST00000030457.12
    Conserved Domains (3) summary
    sd00006
    Location:203231
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:201277
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:203240
    SHNi-TPR
  2. NM_001284229.1NP_001271158.1  nuclear autoantigenic sperm protein isoform 3

    See identical proteins and their annotated locations for NP_001271158.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AF095722, AK083333, AL669953
    Consensus CDS
    CCDS71451.1
    UniProtKB/Swiss-Prot
    Q99MD9
    Related
    ENSMUSP00000079946.5, ENSMUST00000081182.5
    Conserved Domains (3) summary
    sd00006
    Location:176204
    TPR; TPR repeat [structural motif]
    pfam10516
    Location:176213
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:173250
    TPR_12; Tetratricopeptide repeat
  3. NM_016777.3NP_058057.3  nuclear autoantigenic sperm protein isoform 2

    See identical proteins and their annotated locations for NP_058057.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AL669953, BX004835
    Consensus CDS
    CCDS18513.1
    UniProtKB/TrEMBL
    B1AU75
    Related
    ENSMUSP00000030456.8, ENSMUST00000030456.14
    Conserved Domains (4) summary
    TIGR00927
    Location:250505
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00006
    Location:528556
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:526602
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:528565
    SHNi-TPR

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116458249..116488894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253656.2XP_030109516.1  nuclear autoantigenic sperm protein isoform X1

    UniProtKB/TrEMBL
    B1AU75
    Conserved Domains (4) summary
    TIGR00927
    Location:250505
    2A1904; K+-dependent Na+/Ca+ exchanger
    sd00006
    Location:528556
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:526602
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:528565
    SHNi-TPR