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NASP nuclear autoantigenic sperm protein [ Homo sapiens (human) ]

Gene ID: 4678, updated on 1-Jun-2020

Summary

Official Symbol
NASPprovided by HGNC
Official Full Name
nuclear autoantigenic sperm proteinprovided by HGNC
Primary source
HGNC:HGNC:7644
See related
Ensembl:ENSG00000132780 MIM:603185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMDRA1; FLB7527; PRO1999
Summary
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 44.0), bone marrow (RPKM 30.2) and 24 other tissues See more
Orthologs

Genomic context

See NASP in Genome Data Viewer
Location:
1p34.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (45583988..45618906)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46049660..46084578)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene aldo-keto reductase family 1 member A1 Neighboring gene coiled-coil domain containing 17 Neighboring gene GC-rich promoter binding protein 1 like 1 Neighboring gene ribosomal protein S15a pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of nuclear autoantigenic sperm protein (NASP) in Jurkat cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear autoantigenic sperm protein (histone-binding) (NASP) at amino acid residues 676-677 and 759-760 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2297, FLJ31599, FLJ35510, MGC19722, MGC20372, DKFZp547F162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication-dependent nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-dependent nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
blastocyst development ISS
Inferred from Sequence or Structural Similarity
more info
 
histone exchange ISS
Inferred from Sequence or Structural Similarity
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear autoantigenic sperm protein
Names
NASP histone chaperone
histone H1-binding protein
nuclear autoantigenic sperm protein (histone-binding)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029224.1 RefSeqGene

    Range
    5054..39906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195193.1NP_001182122.1  nuclear autoantigenic sperm protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 4), compared to isoform 2.
    Source sequence(s)
    AK291637, AK298893, BC010105, CK300084, CX781565, DC361634
    Consensus CDS
    CCDS55597.1
    UniProtKB/Swiss-Prot
    P49321
    Related
    ENSP00000438871.1, ENST00000537798.5
    Conserved Domains (4) summary
    sd00006
    Location:478506
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:520552
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:478515
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:475552
    TPR_12; Tetratricopeptide repeat
  2. NM_002482.4NP_002473.2  nuclear autoantigenic sperm protein isoform 2

    See identical proteins and their annotated locations for NP_002473.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AK291637, BC010105, CK300084, DC361634
    Consensus CDS
    CCDS524.1
    UniProtKB/Swiss-Prot
    P49321
    Related
    ENSP00000255120.5, ENST00000350030.8
    Conserved Domains (4) summary
    sd00006
    Location:542570
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:584616
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:542579
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:539616
    TPR_12; Tetratricopeptide repeat
  3. NM_152298.4NP_689511.2  nuclear autoantigenic sperm protein isoform 3

    See identical proteins and their annotated locations for NP_689511.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter protein (isoform 3), compared to isoform 2.
    Source sequence(s)
    AK291637, BC053608, CK300084, DC361634
    Consensus CDS
    CCDS525.1
    UniProtKB/Swiss-Prot
    P49321
    UniProtKB/TrEMBL
    Q5T626
    Related
    ENSP00000255121.4, ENST00000351223.7
    Conserved Domains (4) summary
    sd00006
    Location:203231
    TPR; TPR repeat [structural motif]
    pfam10516
    Location:203240
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:201277
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:138340
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    45583988..45618906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270888.3XP_005270945.1  nuclear autoantigenic sperm protein isoform X1

    See identical proteins and their annotated locations for XP_005270945.1

    UniProtKB/Swiss-Prot
    P49321
    Conserved Domains (4) summary
    sd00006
    Location:544572
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:586618
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:544581
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:541618
    TPR_12; Tetratricopeptide repeat
  2. XM_011541509.2XP_011539811.1  nuclear autoantigenic sperm protein isoform X2

    Conserved Domains (4) summary
    sd00006
    Location:544572
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:586618
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:544581
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:541618
    TPR_12; Tetratricopeptide repeat
  3. XM_005270889.3XP_005270946.1  nuclear autoantigenic sperm protein isoform X3

    See identical proteins and their annotated locations for XP_005270946.1

    Conserved Domains (4) summary
    sd00006
    Location:205233
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:247279
    TPR_1; Tetratricopeptide repeat
    pfam10516
    Location:205242
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:202279
    TPR_12; Tetratricopeptide repeat
  4. XM_017001356.2XP_016856845.1  nuclear autoantigenic sperm protein isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172164.1: Suppressed sequence

    Description
    NM_172164.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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