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ATP5F1C ATP synthase F1 subunit gamma [ Homo sapiens (human) ]

Gene ID: 509, updated on 6-Jan-2019

Summary

Official Symbol
ATP5F1Cprovided by HGNC
Official Full Name
ATP synthase F1 subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:833
See related
Ensembl:ENSG00000165629 MIM:108729
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5C; ATP5C1; ATP5CL1
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 224.0), adrenal (RPKM 140.8) and 25 other tissues See more
Orthologs

Genomic context

See ATP5F1C in Genome Data Viewer
Location:
10p14
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (7788104..7807801)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7830093..7849764)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC105376392 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC105376394

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit gamma 1 of mitochondrial ATP synthase F1 complex (ATP5C1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
capsid gag The interaction of HIV-1 CA with human cellular ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ATP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
ATP hydrolysis coupled cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
oxidative phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATP synthase subunit gamma, mitochondrial
Names
ATP synthase gamma chain, mitochondrial
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
F-ATPase gamma subunit
mitochondrial ATP synthase, gamma subunit 1
NP_001001973.1
NP_001307815.1
NP_005165.1
XP_016871779.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001973.3NP_001001973.1  ATP synthase subunit gamma, mitochondrial isoform L (liver) precursor

    See identical proteins and their annotated locations for NP_001001973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (L), also known as a liver type isoform.
    Source sequence(s)
    BC026049, BQ893894, D16562
    Consensus CDS
    CCDS31142.1
    UniProtKB/Swiss-Prot
    P36542
    UniProtKB/TrEMBL
    Q8TAS0
    Related
    ENSP00000349142.7, ENST00000356708.11
    Conserved Domains (1) summary
    TIGR01146
    Location:26297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
  2. NM_001320886.1NP_001307815.1  ATP synthase subunit gamma, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, which lacks a mitochondrial transit peptide compared to isoforms L and H.
    Source sequence(s)
    BC026049, BE161935, BI603806, CB144767
    UniProtKB/TrEMBL
    Q8TAS0
    Conserved Domains (1) summary
    TIGR01146
    Location:1250
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
  3. NM_005174.3NP_005165.1  ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor

    See identical proteins and their annotated locations for NP_005165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the coding region compared to variant 1. The resulting isoform (H), also known as a heart type isoform, contains a shorter and distinct C-terminus compared to isoform L.
    Source sequence(s)
    BC026049, BE161935, BQ893894, CB144767, D16563
    Consensus CDS
    CCDS7081.1
    UniProtKB/Swiss-Prot
    P36542
    UniProtKB/TrEMBL
    Q8TAS0
    Related
    ENSP00000338568.4, ENST00000335698.4
    Conserved Domains (1) summary
    TIGR01146
    Location:26297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    7788104..7807801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016290.1XP_016871779.1  ATP synthase subunit gamma, mitochondrial isoform X1

    UniProtKB/TrEMBL
    B4DL14
    Conserved Domains (1) summary
    TIGR01146
    Location:1250
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
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