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Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 11949, updated on 24-Apr-2022

Summary

Official Symbol
Atp5c1provided by MGI
Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1provided by MGI
Primary source
MGI:MGI:1261437
See related
Ensembl:ENSMUSG00000025781 AllianceGenome:MGI:1261437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5f1c; 1700094F02Rik
Summary
Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 316.7), kidney adult (RPKM 177.9) and 28 other tissues See more
Orthologs
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Genomic context

See Atp5c1 in Genome Data Viewer
Location:
2; 2 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10060841..10085321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10056030..10080510, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (9977657..10002137, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31290 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene predicted gene, 54137 Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP synthase subunit gamma, mitochondrial
Names
ATP synthase F1 subunit gamma
ATP synthase gamma-subunit gene encoding a mitochondrial protein
F-ATPase gamma subunit
F1 gamma
NP_001106209.1
NP_001361570.1
NP_065640.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112738.1NP_001106209.1  ATP synthase subunit gamma, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001106209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK158675, BC055785
    Consensus CDS
    CCDS50497.1
    UniProtKB/TrEMBL
    Q3UD06, Q8C2Q8
    Related
    ENSMUSP00000110546.2, ENSMUST00000114896.8
    Conserved Domains (1) summary
    TIGR01146
    Location:2273
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
  2. NM_001374641.1NP_001361570.1  ATP synthase subunit gamma, mitochondrial isoform c

    Status: VALIDATED

    Source sequence(s)
    AL772367
    Consensus CDS
    CCDS89426.1
    Related
    ENSMUSP00000026887.8, ENSMUST00000026887.14
    Conserved Domains (1) summary
    TIGR01146
    Location:26297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit
  3. NM_020615.4NP_065640.2  ATP synthase subunit gamma, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_065640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform a).
    Source sequence(s)
    AK158675, BC055785
    Consensus CDS
    CCDS38045.1
    UniProtKB/Swiss-Prot
    Q91VR2
    UniProtKB/TrEMBL
    Q3UD06
    Related
    ENSMUSP00000110547.3, ENSMUST00000114897.9
    Conserved Domains (1) summary
    TIGR01146
    Location:26297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    10060841..10085321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)