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Tmod3 tropomodulin 3 [ Mus musculus (house mouse) ]

Gene ID: 50875, updated on 5-Mar-2024

Summary

Official Symbol
Tmod3provided by MGI
Official Full Name
tropomodulin 3provided by MGI
Primary source
MGI:MGI:1355315
See related
Ensembl:ENSMUSG00000058587 AllianceGenome:MGI:1355315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UTMOD; U-Tmod
Summary
Enables tropomyosin binding activity. Acts upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in striated muscle thin filament. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human TMOD3 (tropomodulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.7), placenta adult (RPKM 7.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tmod3 in Genome Data Viewer
Location:
9 D; 9 42.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75405066..75466939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75497784..75559657, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Leo1, Paf1/RNA polymerase II complex component Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538 Neighboring gene predicted gene 7972 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene tropomodulin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tropomyosin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tropomodulin-3
Names
tropomodulin 3; ubiquitous tropomodulin
ubiquitous tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357828.1NP_001344757.1  tropomodulin-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC115880, AC123832
    UniProtKB/TrEMBL
    Q8C3Z3
    Conserved Domains (1) summary
    cl26161
    Location:60172
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_016963.2NP_058659.1  tropomodulin-3 isoform 1

    See identical proteins and their annotated locations for NP_058659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF237630, AK147017, BY067594
    Consensus CDS
    CCDS23344.1
    UniProtKB/Swiss-Prot
    Q3TIT1, Q9JHJ0
    UniProtKB/TrEMBL
    Q3TFA9
    Related
    ENSMUSP00000072087.8, ENSMUST00000072232.9
    Conserved Domains (2) summary
    cd00116
    Location:199311
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5144
    Tropomodulin; Tropomodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75405066..75466939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)