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TMOD3 tropomodulin 3 [ Homo sapiens (human) ]

Gene ID: 29766, updated on 5-Apr-2020

Summary

Official Symbol
TMOD3provided by HGNC
Official Full Name
tropomodulin 3provided by HGNC
Primary source
HGNC:HGNC:11873
See related
Ensembl:ENSG00000138594 MIM:605112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UTMOD
Expression
Ubiquitous expression in esophagus (RPKM 45.0), lung (RPKM 23.8) and 24 other tissues See more
Orthologs

Genomic context

See TMOD3 in Genome Data Viewer
Location:
15q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (51829653..51915725)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52121825..52204335)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene LysM domain containing 2 Neighboring gene tropomodulin 2 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component pseudogene Neighboring gene RNA, U6 small nuclear 90, pseudogene Neighboring gene uncharacterized LOC112268148 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding involved in cell-cell adhesion HDA PubMed 
tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
adherens junction HDA PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tropomodulin-3
Names
tropomodulin 3 (ubiquitous)
ubiquitous tropomodulin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014547.5NP_055362.1  tropomodulin-3

    See identical proteins and their annotated locations for NP_055362.1

    Status: VALIDATED

    Source sequence(s)
    AC090971, AL137543, BC020542, BM975185
    Consensus CDS
    CCDS10145.1
    UniProtKB/Swiss-Prot
    Q9NYL9
    Related
    ENSP00000308753.7, ENST00000308580.12
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
    cl26161
    Location:216292
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    51829653..51915725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022087.1XP_016877576.1  tropomodulin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYL9
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
    cl26161
    Location:216292
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_017022088.1XP_016877577.1  tropomodulin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYL9
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
    cl26161
    Location:216292
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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