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NEUROG3 neurogenin 3 [ Homo sapiens (human) ]

Gene ID: 50674, updated on 15-Mar-2020

Summary

Official Symbol
NEUROG3provided by HGNC
Official Full Name
neurogenin 3provided by HGNC
Primary source
HGNC:HGNC:13806
See related
Ensembl:ENSG00000122859 MIM:604882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ngn3; Atoh5; NGN-3; Math4B; bHLHa7
Summary
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Expression
Biased expression in duodenum (RPKM 1.5), small intestine (RPKM 0.6) and 2 other tissues See more
Orthologs

Genomic context

See NEUROG3 in Genome Data Viewer
Location:
10q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (69571440..69573425, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71331791..71333210, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene uncharacterized LOC101929021 Neighboring gene NEUROG3 upstream region homotypic clusters of transcription factor binding sites enhancer Neighboring gene MT-ATP6 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neurogenin 3 (NEUROG3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
transdifferentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurogenin-3
Names
class A basic helix-loop-helix protein 7
protein atonal homolog 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021321.1 RefSeqGene

    Range
    5033..6757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020999.4NP_066279.2  neurogenin-3

    See identical proteins and their annotated locations for NP_066279.2

    Status: REVIEWED

    Source sequence(s)
    AK313952, AL450311, BC069098
    Consensus CDS
    CCDS31212.1
    UniProtKB/Swiss-Prot
    Q9Y4Z2
    Related
    ENSP00000242462.4, ENST00000242462.5
    Conserved Domains (1) summary
    cd00083
    Location:81140
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    69571440..69573425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016280.1XP_016871769.1  neurogenin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y4Z2
    Conserved Domains (1) summary
    cd00083
    Location:81140
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
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