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Neurog3 neurogenin 3 [ Mus musculus (house mouse) ]

Gene ID: 11925, updated on 18-Jun-2024

Summary

Official Symbol
Neurog3provided by MGI
Official Full Name
neurogenin 3provided by MGI
Primary source
MGI:MGI:893591
See related
Ensembl:ENSMUSG00000044312 AllianceGenome:MGI:893591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ngn3; Atoh5; Math4B; bHLHa7
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of transcription, DNA-templated and transdifferentiation. Acts upstream of or within epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; gut; and nervous system. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 2.0), large intestine adult (RPKM 1.3) and 5 other tissues See more
Orthologs
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Genomic context

See Neurog3 in Genome Data Viewer
Location:
10 B4; 10 32.35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61968869..61970542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62133090..62134763)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene argininosuccinate synthase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26872 Neighboring gene family with sequence similarity 241, member B Neighboring gene STARR-seq mESC enhancer starr_26874 Neighboring gene STARR-positive B cell enhancer mm9_chr10:61645889-61646190 Neighboring gene tetraspanin 15 Neighboring gene microRNA 7662 Neighboring gene STARR-seq mESC enhancer starr_26875 Neighboring gene tachykinin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (15)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC129292, MGC129293

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transdifferentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neurogenin-3
Names
Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B)
atonal homolog 5
helix-loop-helix protein mATH-4B
protein atonal homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009719.6NP_033849.3  neurogenin-3

    See identical proteins and their annotated locations for NP_033849.3

    Status: VALIDATED

    Source sequence(s)
    AC127417
    Consensus CDS
    CCDS23887.1
    UniProtKB/Swiss-Prot
    P70661
    UniProtKB/TrEMBL
    Q548G3, Q9D8I0
    Related
    ENSMUSP00000054054.2, ENSMUST00000050103.2
    Conserved Domains (1) summary
    cd00083
    Location:81140
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61968869..61970542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)