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CYHR1 cysteine and histidine rich 1 [ Homo sapiens (human) ]

Gene ID: 50626, updated on 5-Sep-2021

Summary

Official Symbol
CYHR1provided by HGNC
Official Full Name
cysteine and histidine rich 1provided by HGNC
Primary source
HGNC:HGNC:17806
See related
Ensembl:ENSG00000187954 MIM:616635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHRP
Expression
Ubiquitous expression in testis (RPKM 7.8), prostate (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See CYHR1 in Genome Data Viewer
Location:
8q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144449582..144465701, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145674965..145691084, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VPS28 subunit of ESCRT-I Neighboring gene tonsoku like, DNA repair protein Neighboring gene TONSL antisense RNA 1 Neighboring gene microRNA 6893 Neighboring gene microRNA 10400 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1 regulatory subunit 16A Neighboring gene uncharacterized LOC101928953

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0496, MGC13010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cysteine and histidine-rich protein 1
Names
cysteine and histidine rich protein
cysteine/histidine-rich 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129888.2NP_001123360.1  cysteine and histidine-rich protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001123360.1

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC056412, BC065484
    Consensus CDS
    CCDS6426.1
    UniProtKB/Swiss-Prot
    Q6ZMK1
    Related
    ENSP00000414647.2, ENST00000424149.6
  2. NM_001330618.2NP_001317547.1  cysteine and histidine-rich protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC004544, BG751889, BQ956567
    Consensus CDS
    CCDS83335.1
    UniProtKB/Swiss-Prot
    Q6ZMK1
    UniProtKB/TrEMBL
    E9PJD7
    Related
    ENSP00000433769.1, ENST00000530374.6
    Conserved Domains (2) summary
    cd16505
    Location:108156
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:166227
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  3. NM_032687.4NP_116076.1  cysteine and histidine-rich protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_116076.1

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC005073, BC056412, BM671891
    Consensus CDS
    CCDS6426.1
    UniProtKB/Swiss-Prot
    Q6ZMK1
    Related
    ENSP00000304826.5, ENST00000306145.10
  4. NM_138496.2NP_612505.1  cysteine and histidine-rich protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_612505.1

    Status: VALIDATED

    Source sequence(s)
    AC084125
    Consensus CDS
    CCDS47943.1
    UniProtKB/Swiss-Prot
    Q6ZMK1
    Related
    ENSP00000387426.2, ENST00000438911.6
    Conserved Domains (2) summary
    cl17238
    Location:83114
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl19105
    Location:124185
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144449582..144465701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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