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ZFTRAF1 zinc finger TRAF-type containing 1 [ Homo sapiens (human) ]

Gene ID: 50626, updated on 29-Oct-2022

Summary

Official Symbol
ZFTRAF1provided by HGNC
Official Full Name
zinc finger TRAF-type containing 1provided by HGNC
Primary source
HGNC:HGNC:17806
See related
Ensembl:ENSG00000187954 MIM:616635; AllianceGenome:HGNC:17806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHRP; CYHR1
Summary
Predicted to enable zinc ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.8), prostate (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZFTRAF1 in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144449582..144462871, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145619341..145632631, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145674965..145688254, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VPS28 subunit of ESCRT-I Neighboring gene tonsoku like, DNA repair protein Neighboring gene TONSL antisense RNA 1 Neighboring gene microRNA 6893 Neighboring gene LOC84773-CYHR1 readthrough Neighboring gene microRNA 10400 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough LOC84773-CYHR1

Readthrough gene: LOC84773-CYHR1, Included gene: TMEM276

Homology

Clone Names

  • KIAA0496, MGC13010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger TRAF-type-containing protein 1
Names
Zinc finger TRAF-type-containing protein 1
cysteine and histidine rich 1
cysteine and histidine rich protein
cysteine and histidine-rich protein 1
cysteine/histidine-rich 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330618.2NP_001317547.1  zinc finger TRAF-type-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084125, BC004544, BG751889, BQ956567
    Consensus CDS
    CCDS83335.1
    UniProtKB/Swiss-Prot
    Q6ZMK1
    UniProtKB/TrEMBL
    E9PJD7
    Related
    ENSP00000433769.1, ENST00000530374.6
    Conserved Domains (2) summary
    cd16505
    Location:108156
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:166227
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  2. NM_001408047.1NP_001394976.1  zinc finger TRAF-type-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC084125
  3. NM_001408048.1NP_001394977.1  zinc finger TRAF-type-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084125
  4. NM_001408049.1NP_001394978.1  zinc finger TRAF-type-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC084125

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144449582..144462871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145619341..145632631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)