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Zftraf1 zinc finger TRAF type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 54151, updated on 15-Feb-2023

Summary

Official Symbol
Zftraf1provided by MGI
Official Full Name
zinc finger TRAF type containing 1provided by MGI
Primary source
MGI:MGI:1859320
See related
Ensembl:ENSMUSG00000053929 Ensembl:ENSMUSG00000121583 Ensembl:ENSMUSG00000121584 AllianceGenome:MGI:1859320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chrp; Cyhr1; Tmem276; 1110031M01Rik
Summary
Predicted to enable zinc ion binding activity. Located in cytoplasm and nuclear envelope. Orthologous to human CYHR1 (cysteine and histidine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.7), ovary adult (RPKM 16.0) and 28 other tissues See more
Orthologs
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Genomic context

See Zftraf1 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76527595..76544408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76643395..76660208, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 28 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Tmem276-zftraf1

Readthrough gene: Tmem276-zftraf1, Included gene: Tmem276

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cysteine and histidine-rich protein 1
Names
Transmembrane protein 276
Zinc finger TRAF-type-containing protein 1
cysteine and histidine rich 1
cysteine and histidine-rich cytoplasmic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276321.2NP_001263250.1  cysteine and histidine-rich protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS70643.1
    UniProtKB/TrEMBL
    H3BIV6
    Related
    ENSMUSP00000134739.2, ENSMUST00000176274.2
    Conserved Domains (1) summary
    cl19105
    Location:161222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  2. NM_001357882.2NP_001344811.1  cysteine and histidine-rich protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156550
    UniProtKB/TrEMBL
    A0A6P5R4W3
    Conserved Domains (2) summary
    cd16505
    Location:103151
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:161222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  3. NM_001408103.1NP_001395032.1  cysteine and histidine-rich protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550
  4. NM_001408104.1NP_001395033.1  cysteine and histidine-rich protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156550
  5. NM_001408207.1NP_001395136.1  cysteine and histidine-rich protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156550
  6. NM_001408208.1NP_001395137.1  cysteine and histidine-rich protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76527595..76544408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521167.4XP_006521230.1  cysteine and histidine-rich protein 1 isoform X1

    Conserved Domains (2) summary
    cd16505
    Location:103151
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:161222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  2. XM_006521169.4XP_006521232.1  cysteine and histidine-rich protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006521232.1

    UniProtKB/Swiss-Prot
    Q9QXA1
    UniProtKB/TrEMBL
    A0A6P5QXS5, A0A8C6I0P1
    Conserved Domains (2) summary
    cl17238
    Location:3163
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl19105
    Location:73134
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  3. XM_006521168.4XP_006521231.1  cysteine and histidine-rich protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VI70
    Related
    ENSMUSP00000155816.2, ENSMUST00000229524.2
    Conserved Domains (2) summary
    cd16505
    Location:103151
    RING-HC_CYHR1; RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
    cl19105
    Location:161222
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  4. XM_030248659.2XP_030104519.1  cysteine and histidine-rich protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9QXA1
    UniProtKB/TrEMBL
    A0A8C6N1L1
  5. XM_030248660.2XP_030104520.1  cysteine and histidine-rich protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9QXA1
    UniProtKB/TrEMBL
    A0A8C6N1L1