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PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]

Gene ID: 5058, updated on 28-Sep-2022

Summary

Official Symbol
PAK1provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 1provided by HGNC
Primary source
HGNC:HGNC:8590
See related
Ensembl:ENSG00000149269 MIM:602590; AllianceGenome:HGNC:8590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDMSSD; p65-PAK; PAKalpha; alpha-PAK
Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Expression
Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues See more
Orthologs
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Genomic context

See PAK1 in Genome Data Viewer
Location:
11q13.5-q14.1
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77322017..77530009, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77254590..77407047, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77033062..77185139, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1 Neighboring gene uncharacterized LOC124902722 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:77270938-77272137

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intellectual developmental disorder with macrocephaly, seizures, and speech delay
MedGen: C4748428 OMIM: 618158 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity. The SH3 region mutation 72PXXP/AXXA75 in Nef results in loss of Pak association which decreases Nef-induced MEK1 phosphorylation PubMed
nef HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex PubMed
nef The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity PubMed
nef HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages PubMed
nef HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K) PubMed
nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
nef HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques PubMed
nef The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity PubMed
nef A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays PubMed
Tat tat Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells PubMed
tat HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130000, MGC130001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables molecular function inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
contributes_to small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
NOT involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell proliferation involved in contact inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 1
Names
STE20 homolog, yeast
p21 protein (Cdc42/Rac)-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
NP_001122092.1
NP_001363197.1
NP_001363198.1
NP_001363199.1
NP_001363200.1
NP_001363201.1
NP_001363202.1
NP_001363203.1
NP_001363204.1
NP_001363205.1
NP_001363206.1
NP_001363207.1
NP_001363208.1
NP_001363209.1
NP_001363210.1
NP_001363211.1
NP_001363212.1
NP_001363213.1
NP_001363214.1
NP_001363215.1
NP_001363216.1
NP_001363217.1
NP_001363218.1
NP_001363219.1
NP_001363220.1
NP_001363221.1
NP_001363222.1
NP_001363223.1
NP_001363224.1
NP_001363230.1
NP_001363231.1
NP_001363232.1
NP_001363233.1
NP_001363234.1
NP_002567.3
XP_024304325.1
XP_024304326.1
XP_024304327.1
XP_024304328.1
XP_047283002.1
XP_047283003.1
XP_047283004.1
XP_047283005.1
XP_047283006.1
XP_047283007.1
XP_047283008.1
XP_047283009.1
XP_047283010.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029900.3 RefSeqGene

    Range
    60915..212992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128620.2NP_001122092.1  serine/threonine-protein kinase PAK 1 isoform 1

    See identical proteins and their annotated locations for NP_001122092.1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS44687.1
    UniProtKB/Swiss-Prot
    Q13153
    Related
    ENSP00000278568.4, ENST00000278568.8
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  2. NM_001376268.1NP_001363197.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  3. NM_001376269.1NP_001363198.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  4. NM_001376270.1NP_001363199.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  5. NM_001376271.1NP_001363200.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  6. NM_001376272.1NP_001363201.1  serine/threonine-protein kinase PAK 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:256551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74135
    PBD; P21-Rho-binding domain
  7. NM_001376273.1NP_001363202.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  8. NM_001376274.1NP_001363203.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  9. NM_001376275.1NP_001363204.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  10. NM_001376276.1NP_001363205.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  11. NM_001376277.1NP_001363206.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  12. NM_001376278.1NP_001363207.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  13. NM_001376279.1NP_001363208.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  14. NM_001376280.1NP_001363209.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  15. NM_001376281.1NP_001363210.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  16. NM_001376282.1NP_001363211.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  17. NM_001376283.1NP_001363212.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  18. NM_001376284.1NP_001363213.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  19. NM_001376285.1NP_001363214.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  20. NM_001376286.1NP_001363215.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  21. NM_001376287.1NP_001363216.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  22. NM_001376288.1NP_001363217.1  serine/threonine-protein kinase PAK 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    B3KNX7
    Related
    ENSP00000433423.1, ENST00000530617.5
    Conserved Domains (2) summary
    cd06647
    Location:262518
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  23. NM_001376289.1NP_001363218.1  serine/threonine-protein kinase PAK 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
    cl21453
    Location:262471
    PKc_like; Protein Kinases, catalytic domain
  24. NM_001376290.1NP_001363219.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
    cl21453
    Location:249503
    PKc_like; Protein Kinases, catalytic domain
  25. NM_001376291.1NP_001363220.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
    cl21453
    Location:249503
    PKc_like; Protein Kinases, catalytic domain
  26. NM_001376292.1NP_001363221.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
    cl21453
    Location:249498
    PKc_like; Protein Kinases, catalytic domain
  27. NM_001376293.1NP_001363222.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
    cl21453
    Location:249498
    PKc_like; Protein Kinases, catalytic domain
  28. NM_001376294.1NP_001363223.1  serine/threonine-protein kinase PAK 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
    cl21453
    Location:259472
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001376295.1NP_001363224.1  serine/threonine-protein kinase PAK 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
    cl21453
    Location:274485
    PKc_like; Protein Kinases, catalytic domain
  30. NM_001376301.1NP_001363230.1  serine/threonine-protein kinase PAK 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (1) summary
    cd06654
    Location:166461
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  31. NM_001376302.1NP_001363231.1  serine/threonine-protein kinase PAK 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AP000486
    UniProtKB/TrEMBL
    E9PM17
    Related
    ENSP00000433211.1, ENST00000528203.5
    Conserved Domains (1) summary
    cd06647
    Location:164419
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
  32. NM_001376303.1NP_001363232.1  serine/threonine-protein kinase PAK 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd01093
    Location:73118
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:198448
    PKc_like; Protein Kinases, catalytic domain
  33. NM_001376304.1NP_001363233.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (1) summary
    cd06654
    Location:151446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  34. NM_001376305.1NP_001363234.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (1) summary
    cd06654
    Location:151446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  35. NM_002576.5NP_002567.3  serine/threonine-protein kinase PAK 1 isoform 2

    See identical proteins and their annotated locations for NP_002567.3

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    Q13153, Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Related
    ENSP00000348696.4, ENST00000356341.8
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain

RNA

  1. NR_164797.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486
  2. NR_164798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    77322017..77530009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448560.2XP_024304328.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  2. XM_047427054.1XP_047283010.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
  3. XM_047427049.1XP_047283005.1  serine/threonine-protein kinase PAK 1 isoform X3

  4. XM_047427051.1XP_047283007.1  serine/threonine-protein kinase PAK 1 isoform X3

  5. XM_047427048.1XP_047283004.1  serine/threonine-protein kinase PAK 1 isoform X3

  6. XM_024448559.2XP_024304327.1  serine/threonine-protein kinase PAK 1 isoform X3

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  7. XM_047427053.1XP_047283009.1  serine/threonine-protein kinase PAK 1 isoform X4

    UniProtKB/Swiss-Prot
    Q86W79
    UniProtKB/TrEMBL
    A0A024R5P0
  8. XM_047427050.1XP_047283006.1  serine/threonine-protein kinase PAK 1 isoform X3

  9. XM_024448557.2XP_024304325.1  serine/threonine-protein kinase PAK 1 isoform X3

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  10. XM_047427047.1XP_047283003.1  serine/threonine-protein kinase PAK 1 isoform X2

  11. XM_047427046.1XP_047283002.1  serine/threonine-protein kinase PAK 1 isoform X1

  12. XM_047427052.1XP_047283008.1  serine/threonine-protein kinase PAK 1 isoform X3

  13. XM_024448558.2XP_024304326.1  serine/threonine-protein kinase PAK 1 isoform X3

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    77254590..77407047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)