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PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]

Gene ID: 5058, updated on 10-Oct-2020

Summary

Official Symbol
PAK1provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 1provided by HGNC
Primary source
HGNC:HGNC:8590
See related
Ensembl:ENSG00000149269 MIM:602590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDMSSD; p65-PAK; PAKalpha; alpha-PAK
Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Expression
Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues See more
Orthologs

Genomic context

See PAK1 in Genome Data Viewer
Location:
11q13.5-q14.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (77322017..77514957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77033060..77185108, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1 Neighboring gene uncharacterized LOC646029 Neighboring gene RNA, U7 small nuclear 59 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
GeneReviews: Not available
INTELLECTUAL DEVELOPMENTAL DISORDER WITH MACROCEPHALY, SEIZURES, AND SPEECH DELAY
MedGen: C4748428 OMIM: 618158 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity. The SH3 region mutation 72PXXP/AXXA75 in Nef results in loss of Pak association which decreases Nef-induced MEK1 phosphorylation PubMed
nef HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex PubMed
nef The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity PubMed
nef HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages PubMed
nef HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K) PubMed
nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
nef HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques PubMed
nef The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity PubMed
nef A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays PubMed
Tat tat Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells PubMed
tat HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130000, MGC130001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
collagen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
NOT MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation involved in contact inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular associated smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 1
Names
STE20 homolog, yeast
p21 protein (Cdc42/Rac)-activated kinase 1
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
NP_001122092.1
NP_001363197.1
NP_001363198.1
NP_001363199.1
NP_001363200.1
NP_001363201.1
NP_001363202.1
NP_001363203.1
NP_001363204.1
NP_001363205.1
NP_001363206.1
NP_001363207.1
NP_001363208.1
NP_001363209.1
NP_001363210.1
NP_001363211.1
NP_001363212.1
NP_001363213.1
NP_001363214.1
NP_001363215.1
NP_001363216.1
NP_001363217.1
NP_001363218.1
NP_001363219.1
NP_001363220.1
NP_001363221.1
NP_001363222.1
NP_001363223.1
NP_001363224.1
NP_001363230.1
NP_001363231.1
NP_001363232.1
NP_001363233.1
NP_001363234.1
NP_002567.3
XP_011543384.1
XP_011543386.1
XP_016873335.1
XP_024304325.1
XP_024304326.1
XP_024304327.1
XP_024304328.1
XP_024304330.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029900.2 RefSeqGene

    Range
    5001..157049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128620.2NP_001122092.1  serine/threonine-protein kinase PAK 1 isoform 1

    See identical proteins and their annotated locations for NP_001122092.1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS44687.1
    UniProtKB/Swiss-Prot
    Q13153
    Related
    ENSP00000278568.4, ENST00000278568.8
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  2. NM_001376268.1NP_001363197.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  3. NM_001376269.1NP_001363198.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  4. NM_001376270.1NP_001363199.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  5. NM_001376271.1NP_001363200.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  6. NM_001376272.1NP_001363201.1  serine/threonine-protein kinase PAK 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000486
  7. NM_001376273.1NP_001363202.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  8. NM_001376274.1NP_001363203.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  9. NM_001376275.1NP_001363204.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  10. NM_001376276.1NP_001363205.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  11. NM_001376277.1NP_001363206.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  12. NM_001376278.1NP_001363207.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  13. NM_001376279.1NP_001363208.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  14. NM_001376280.1NP_001363209.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  15. NM_001376281.1NP_001363210.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  16. NM_001376282.1NP_001363211.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  17. NM_001376283.1NP_001363212.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  18. NM_001376284.1NP_001363213.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  19. NM_001376285.1NP_001363214.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  20. NM_001376286.1NP_001363215.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  21. NM_001376287.1NP_001363216.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  22. NM_001376288.1NP_001363217.1  serine/threonine-protein kinase PAK 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Related
    ENSP00000433423.1, ENST00000530617.5
    Conserved Domains (2) summary
    cd06647
    Location:262518
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  23. NM_001376289.1NP_001363218.1  serine/threonine-protein kinase PAK 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP000486
  24. NM_001376290.1NP_001363219.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
  25. NM_001376291.1NP_001363220.1  serine/threonine-protein kinase PAK 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP000486
  26. NM_001376292.1NP_001363221.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
  27. NM_001376293.1NP_001363222.1  serine/threonine-protein kinase PAK 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP000486
  28. NM_001376294.1NP_001363223.1  serine/threonine-protein kinase PAK 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AP000486
  29. NM_001376295.1NP_001363224.1  serine/threonine-protein kinase PAK 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP000486
  30. NM_001376301.1NP_001363230.1  serine/threonine-protein kinase PAK 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (1) summary
    cd06654
    Location:166461
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  31. NM_001376302.1NP_001363231.1  serine/threonine-protein kinase PAK 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Related
    ENSP00000433211.1, ENST00000528203.5
    Conserved Domains (1) summary
    cd06647
    Location:164419
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
  32. NM_001376303.1NP_001363232.1  serine/threonine-protein kinase PAK 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (2) summary
    cd01093
    Location:73118
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:198448
    PKc_like; Protein Kinases, catalytic domain
  33. NM_001376304.1NP_001363233.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Conserved Domains (1) summary
    cd06654
    Location:151446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  34. NM_001376305.1NP_001363234.1  serine/threonine-protein kinase PAK 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AP000486
    Conserved Domains (1) summary
    cd06654
    Location:151446
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
  35. NM_002576.5NP_002567.3  serine/threonine-protein kinase PAK 1 isoform 2

    See identical proteins and their annotated locations for NP_002567.3

    Status: REVIEWED

    Source sequence(s)
    AP000486, AP003680
    Consensus CDS
    CCDS8250.1
    UniProtKB/Swiss-Prot
    Q13153
    UniProtKB/TrEMBL
    A0A024R5P0
    Related
    ENSP00000348696.3, ENST00000356341.7
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain

RNA

  1. NR_164797.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486
  2. NR_164798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP000486

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    77322017..77514957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448560.1XP_024304328.1  serine/threonine-protein kinase PAK 1 isoform X1

    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  2. XM_024448562.1XP_024304330.1  serine/threonine-protein kinase PAK 1 isoform X1

    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  3. XM_017017846.1XP_016873335.1  serine/threonine-protein kinase PAK 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13153
    UniProtKB/TrEMBL
    A0A024R5P0
    Conserved Domains (2) summary
    cd06654
    Location:249544
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  4. XM_024448559.1XP_024304327.1  serine/threonine-protein kinase PAK 1 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  5. XM_011545084.3XP_011543386.1  serine/threonine-protein kinase PAK 1 isoform X2

    See identical proteins and their annotated locations for XP_011543386.1

    UniProtKB/Swiss-Prot
    Q13153
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  6. XM_024448557.1XP_024304325.1  serine/threonine-protein kinase PAK 1 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  7. XM_011545082.2XP_011543384.1  serine/threonine-protein kinase PAK 1 isoform X2

    See identical proteins and their annotated locations for XP_011543384.1

    UniProtKB/Swiss-Prot
    Q13153
    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  8. XM_024448558.1XP_024304326.1  serine/threonine-protein kinase PAK 1 isoform X2

    Conserved Domains (2) summary
    cd06647
    Location:262517
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
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