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Pak1 p21 (RAC1) activated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18479, updated on 8-Nov-2022

Summary

Official Symbol
Pak1provided by MGI
Official Full Name
p21 (RAC1) activated kinase 1provided by MGI
Primary source
MGI:MGI:1339975
See related
Ensembl:ENSMUSG00000030774 AllianceGenome:MGI:1339975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paka; PAK-1
Summary
Enables protein serine/threonine kinase activity. Involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including glutamatergic synapse; growth cone; and postsynaptic density. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues See more
Orthologs
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Genomic context

See Pak1 in Genome Data Viewer
Location:
7 E1; 7 53.57 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97437748..97561588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97788541..97912381)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene aquaporin 11 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene Neighboring gene myosin VIIA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amygdala development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glutamate secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular junction development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within observational learning IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor clustering IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transmission of nerve impulse IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 1
Names
CDC42/RAC effector kinase PAK-A
P21 CDKN1A-activated kinase 1
activated protein kinase alpha
alpha-PAK
p21 protein (Cdc42/Rac)-activated kinase 1
p21-activated kinase 1
p65-PAK
NP_001344291.1
NP_001344292.1
NP_001344293.1
NP_001344294.1
NP_035165.2
XP_006507499.1
XP_006507500.1
XP_011239996.1
XP_036008662.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357362.2NP_001344291.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2 and 6 encode the same isoform (2).
    Source sequence(s)
    AC120438
    Conserved Domains (2) summary
    cd06654
    Location:256551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  2. NM_001357363.2NP_001344292.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC120438
    Consensus CDS
    CCDS21464.1
    UniProtKB/TrEMBL
    A0A6P7R2Z2, G5E884
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  3. NM_001357364.2NP_001344293.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC120438, AC151477
    Consensus CDS
    CCDS21464.1
    UniProtKB/TrEMBL
    A0A6P7R2Z2, G5E884
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  4. NM_001357365.2NP_001344294.1  serine/threonine-protein kinase PAK 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC120438, AC151477
    Consensus CDS
    CCDS21464.1
    UniProtKB/TrEMBL
    A0A6P7R2Z2, G5E884
    Related
    ENSMUSP00000146055.2, ENSMUST00000206984.2
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  5. NM_001403479.1NP_001390408.1  serine/threonine-protein kinase PAK 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2 and 6 encode the same isoform (2).
    Source sequence(s)
    AC120438
  6. NM_011035.3NP_035165.2  serine/threonine-protein kinase PAK 1 isoform 1

    See identical proteins and their annotated locations for NP_035165.2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 3, 4, and 5 encode the same isoform (1).
    Source sequence(s)
    AC120438
    Consensus CDS
    CCDS21464.1
    UniProtKB/TrEMBL
    A0A6P7R2Z2, G5E884
    Related
    ENSMUSP00000033040.6, ENSMUST00000033040.12
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    97437748..97561588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507436.5XP_006507499.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006507499.1

    Conserved Domains (2) summary
    cd06654
    Location:256551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  2. XM_036152769.1XP_036008662.1  serine/threonine-protein kinase PAK 1 isoform X2

    UniProtKB/TrEMBL
    A0A6P7R2Z2, G5E884
    Conserved Domains (2) summary
    cd06654
    Location:248543
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74132
    PBD; P21-Rho-binding domain
  3. XM_006507437.4XP_006507500.1  serine/threonine-protein kinase PAK 1 isoform X1

    See identical proteins and their annotated locations for XP_006507500.1

    Conserved Domains (2) summary
    cd06654
    Location:256551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain
  4. XM_011241694.2XP_011239996.1  serine/threonine-protein kinase PAK 1 isoform X1

    Conserved Domains (2) summary
    cd06654
    Location:256551
    STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
    pfam00786
    Location:74128
    PBD; P21-Rho-binding domain