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PRDX1 peroxiredoxin 1 [ Homo sapiens (human) ]

Gene ID: 5052, updated on 28-Nov-2020

Summary

Official Symbol
PRDX1provided by HGNC
Official Full Name
peroxiredoxin 1provided by HGNC
Primary source
HGNC:HGNC:9352
See related
Ensembl:ENSG00000117450 MIM:176763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues See more
Orthologs

Genomic context

See PRDX1 in Genome Data Viewer
Location:
1p34.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (45511051..45522890, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45976707..45988562, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene Sharpr-MPRA regulatory region 45 Neighboring gene coiled-coil domain containing 163 Neighboring gene metabolism of cobalamin associated C Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene aldo-keto reductase family 1 member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cobalamin C disease not available
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of peroxiredoxin 1, 3, and 4 proteins in umbilical cord blood mononuclear cells and T-cell lines PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 1 (PRDX1) at amino acid residues 49-50 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retina homeostasis HEP PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxiredoxin-1
Names
epididymis secretory sperm binding protein
natural killer cell-enhancing factor A
natural killer-enhancing factor A
proliferation-associated gene A
proliferation-associated gene protein
thioredoxin peroxidase 2
thioredoxin-dependent peroxide reductase 2
thioredoxin-dependent peroxiredoxin 1
NP_001189360.1
NP_002565.1
NP_859047.1
NP_859048.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202431.2NP_001189360.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_001189360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different exon for part of its 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AI912389, BM740381, BM787105
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830
    Related
    ENSP00000389047.1, ENST00000424390.1
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_002574.4NP_002565.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_002565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB451388, AI912389, BM827394
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830
    Related
    ENSP00000262746.1, ENST00000262746.5
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  3. NM_181696.3NP_859047.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_859047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB451388, AI912389, BM762399, CD638470
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  4. NM_181697.3NP_859048.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_859048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    BC021683
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830
    Related
    ENSP00000361152.5, ENST00000319248.13
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    45511051..45522890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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