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PRDX1 peroxiredoxin 1 [ Homo sapiens (human) ]

Gene ID: 5052, updated on 4-Dec-2022

Summary

Official Symbol
PRDX1provided by HGNC
Official Full Name
peroxiredoxin 1provided by HGNC
Primary source
HGNC:HGNC:9352
See related
Ensembl:ENSG00000117450 MIM:176763; AllianceGenome:HGNC:9352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues See more
Orthologs
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Genomic context

See PRDX1 in Genome Data Viewer
Location:
1p34.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45511051..45522890, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45383419..45395258, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45976723..45988562, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene Sharpr-MPRA regulatory region 45 Neighboring gene CCDC163 homolog Neighboring gene metabolism of cobalamin associated C Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene aldo-keto reductase family 1 member A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cobalamin C disease Compare labs

EBI GWAS Catalog

Description
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of peroxiredoxin 1, 3, and 4 proteins in umbilical cord blood mononuclear cells and T-cell lines PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 1 (PRDX1) at amino acid residues 49-50 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peroxidase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to chemical stress TAS
Traceable Author Statement
more info
 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina homeostasis HEP PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxiredoxin-1
Names
epididymis secretory sperm binding protein
natural killer cell-enhancing factor A
natural killer-enhancing factor A
proliferation-associated gene A
proliferation-associated gene protein
thioredoxin peroxidase 2
thioredoxin-dependent peroxide reductase 2
thioredoxin-dependent peroxiredoxin 1
NP_001189360.1
NP_002565.1
NP_859047.1
NP_859048.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202431.2NP_001189360.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_001189360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different exon for part of its 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AI912389, BM740381, BM787105
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830, Q5T155
    UniProtKB/TrEMBL
    A0A384NPQ2
    Related
    ENSP00000389047.2, ENST00000424390.2
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_002574.4NP_002565.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_002565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB451388, AI912389, BM827394
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830, Q5T155
    UniProtKB/TrEMBL
    A0A384NPQ2
    Related
    ENSP00000262746.1, ENST00000262746.5
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  3. NM_181696.3NP_859047.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_859047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB451388, AI912389, BM762399, CD638470
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830, Q5T155
    UniProtKB/TrEMBL
    A0A384NPQ2
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  4. NM_181697.3NP_859048.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_859048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    BC021683
    Consensus CDS
    CCDS522.1
    UniProtKB/Swiss-Prot
    Q06830, Q5T155
    UniProtKB/TrEMBL
    A0A384NPQ2
    Related
    ENSP00000361152.5, ENST00000319248.13
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45511051..45522890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45383419..45395258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)