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Prdx1 peroxiredoxin 1 [ Mus musculus (house mouse) ]

Gene ID: 18477, updated on 8-Jan-2023

Summary

Official Symbol
Prdx1provided by MGI
Official Full Name
peroxiredoxin 1provided by MGI
Primary source
MGI:MGI:99523
See related
Ensembl:ENSMUSG00000028691 AllianceGenome:MGI:99523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAG; OSF3; Paga; PrxI; TDX2; TPxA; prx1; MSP23; NkefA; OSF-3; PrdxI; Tdpx2
Summary
Enables identical protein binding activity. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; regulation of intracellular signal transduction; and removal of superoxide radicals. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 260.9), placenta adult (RPKM 195.3) and 27 other tissues See more
Orthologs
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Genomic context

See Prdx1 in Genome Data Viewer
Location:
4 D1; 4 53.28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116542796..116557197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116685599..116700000)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member A1 (aldehyde reductase) Neighboring gene predicted gene, 25137 Neighboring gene expressed sequence AV051173 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene testis-specific kinase 2 Neighboring gene target of EGR1, member 1 (nuclear)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peroxiredoxin activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-1
Names
Trx dependent peroxide reductase 2
macrophage 23 Kd stress protein
macrophage 23 kDa stress protein
macrophage 23kDa stress protein
macrophase stress protein 22kDa
macrophase stress protein 23 kd
osteoblast-specific factor 3
proliferation-associated gene A
thioredoxin peroxidase 2
thioredoxin-dependent peroxide reductase 2
thioredoxin-dependent peroxiredoxin 1
NP_035164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011034.5NP_035164.1  peroxiredoxin-1

    See identical proteins and their annotated locations for NP_035164.1

    Status: VALIDATED

    Source sequence(s)
    AL831786
    Consensus CDS
    CCDS18515.1
    UniProtKB/Swiss-Prot
    P35700, Q9CWI2
    UniProtKB/TrEMBL
    A0A8C6H3E3
    Related
    ENSMUSP00000114159.2, ENSMUST00000135573.8
    Conserved Domains (1) summary
    cd03015
    Location:8180
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116542796..116557197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)