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PEBP1 phosphatidylethanolamine binding protein 1 [ Homo sapiens (human) ]

Gene ID: 5037, updated on 24-Nov-2020

Summary

Official Symbol
PEBP1provided by HGNC
Official Full Name
phosphatidylethanolamine binding protein 1provided by HGNC
Primary source
HGNC:HGNC:8630
See related
Ensembl:ENSG00000089220 MIM:604591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; HEL-S-96
Summary
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
Expression
Broad expression in adrenal (RPKM 735.7), liver (RPKM 426.0) and 23 other tissues See more
Orthologs

Genomic context

See PEBP1 in Genome Data Viewer
Location:
12q24.23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (118136124..118145584)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118573668..118583390)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene uncharacterized LOC101928274 Neighboring gene Sharpr-MPRA regulatory region 576 Neighboring gene TAO kinase 3 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene SDS3 homolog, SIN3A corepressor complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein phosphatidylethanolamine binding protein 1 (PEBP1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylethanolamine binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
phosphatidylethanolamine-binding protein 1
Names
Raf kinase inhibitory protein
epididymis luminal protein 210
epididymis secretory protein Li 34
epididymis secretory protein Li 96
hippocampal cholinergic neurostimulating peptide
neuropolypeptide h3
prostatic binding protein
raf kinase inhibitor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002567.4NP_002558.1  phosphatidylethanolamine-binding protein 1

    See identical proteins and their annotated locations for NP_002558.1

    Status: REVIEWED

    Source sequence(s)
    BC031102, BF978793, X75252
    Consensus CDS
    CCDS9187.1
    UniProtKB/Swiss-Prot
    P30086
    UniProtKB/TrEMBL
    D9IAI1
    Related
    ENSP00000261313.2, ENST00000261313.3
    Conserved Domains (1) summary
    cd00866
    Location:23171
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    118136124..118145584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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