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Pebp1 phosphatidylethanolamine binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23980, updated on 1-Mar-2024

Summary

Official Symbol
Pebp1provided by MGI
Official Full Name
phosphatidylethanolamine binding protein 1provided by MGI
Primary source
MGI:MGI:1344408
See related
Ensembl:ENSMUSG00000032959 AllianceGenome:MGI:1344408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pbp; HCNP; Pbp1; Pbpr; Rkip
Summary
Predicted to enable ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Acts upstream of or within sperm capacitation. Located in cell surface. Is expressed in embryo; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 1168.4), adrenal adult (RPKM 808.9) and 28 other tissues See more
Orthologs
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Genomic context

See Pebp1 in Genome Data Viewer
Location:
5 F; 5 56.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117420716..117425629, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117282651..117287564, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene suppressor of defective silencing 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene predicted gene 3786 Neighboring gene cDNA sequence BC051077 Neighboring gene predicted gene, 52828

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102065, MGC103131

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylethanolamine-binding protein 1
Names
HCNPpp
PEBP-1
Raf-1 inhibitor protein
Raf-1 kinase inhibitor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018858.2NP_061346.2  phosphatidylethanolamine-binding protein 1

    See identical proteins and their annotated locations for NP_061346.2

    Status: PROVISIONAL

    Source sequence(s)
    BC083063
    Consensus CDS
    CCDS39234.1
    UniProtKB/Swiss-Prot
    P70296, Q9D8G9, Q9JJ58
    UniProtKB/TrEMBL
    Q3TGC5, Q5EBQ2
    Related
    ENSMUSP00000048425.7, ENSMUST00000036951.13
    Conserved Domains (1) summary
    cd00866
    Location:25171
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117420716..117425629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)