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PA2G4 proliferation-associated 2G4 [ Homo sapiens (human) ]

Gene ID: 5036, updated on 21-Sep-2021


Official Symbol
PA2G4provided by HGNC
Official Full Name
proliferation-associated 2G4provided by HGNC
Primary source
See related
Ensembl:ENSG00000170515 MIM:602145
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBP1; HG4-1; p38-2G4
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
Ubiquitous expression in skin (RPKM 37.0), esophagus (RPKM 35.3) and 25 other tissues See more
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Genomic context

See PA2G4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56104559..56113910)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56498343..56507694)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr12.2135 Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene uncharacterized LOC105369782 Neighboring gene ribosomal protein L41 Neighboring gene zinc finger CCCH-type containing 10

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human proliferation-associated 2G4, 38kDa (PA2G4) at amino acid residues 346-347 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables nucleic acid binding IDA
Inferred from Direct Assay
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
involved_in positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
proliferation-associated protein 2G4
ErbB-3 binding protein 1
ErbB-3 receptor binding protein
ErbB3-binding protein Ebp1
cell cycle protein p38-2G4 homolog
erbB3-binding protein 1
proliferation-associated 2G4, 38kD
proliferation-associated 2G4, 38kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006191.3NP_006182.2  proliferation-associated protein 2G4

    See identical proteins and their annotated locations for NP_006182.2

    Status: REVIEWED

    Source sequence(s)
    AC034102, BC001951, BU683753
    Consensus CDS
    ENSP00000302886.6, ENST00000303305.11
    Conserved Domains (1) summary
    crvDNA_42K; 42K curved DNA binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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