Format

Send to:

Choose Destination

ORM1 orosomucoid 1 [ Homo sapiens (human) ]

Gene ID: 5004, updated on 8-Jul-2018
Official Symbol
ORM1provided by HGNC
Official Full Name
orosomucoid 1provided by HGNC
Primary source
HGNC:HGNC:8498
See related
Ensembl:ENSG00000229314 MIM:138600; Vega:OTTHUMG00000021012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORM; AGP1; AGP-A; HEL-S-153w
Summary
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 4993.2) See more
Orthologs
See ORM1 in Genome Data Viewer
Location:
9q32
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (114323023..114326479)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117085303..117088759)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene uncharacterized LOC105376224 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.
NHGRI GWA Catalog
Genome-wide association study of Tourette's syndrome.
NHGRI GWA Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM) PubMed
env Recombinant precursor gp160 (rgp160) or surface unit gp120 (rgp120) of HIV-1 and alpha 1-acid glycoprotein (AGP) show a specific low-affinity binding via N-linked glycans PubMed

Go to the HIV-1, Human Interaction Database

  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
alpha-1-acid glycoprotein 1
Names
AGP 1
OMD 1
epididymis secretory sperm binding protein Li 153w

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012108.1 RefSeqGene

    Range
    5001..8457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000607.2NP_000598.2  alpha-1-acid glycoprotein 1 precursor

    See identical proteins and their annotated locations for NP_000598.2

    Status: REVIEWED

    Source sequence(s)
    BI908589, M13692, N68733
    Consensus CDS
    CCDS6803.1
    UniProtKB/Swiss-Prot
    P02763
    Related
    ENSP00000259396.8, OTTHUMP00000022741, ENST00000259396.8, OTTHUMT00000055426
    Conserved Domains (1) summary
    pfam00061
    Location:40180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    114323023..114326479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center