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Orm1 orosomucoid 1 [ Mus musculus (house mouse) ]

Gene ID: 18405, updated on 27-Feb-2024

Summary

Official Symbol
Orm1provided by MGI
Official Full Name
orosomucoid 1provided by MGI
Primary source
MGI:MGI:97443
See related
Ensembl:ENSMUSG00000039196 AllianceGenome:MGI:97443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agp-1; Agp-2; Orm-1
Summary
This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015]
Expression
Biased expression in liver adult (RPKM 234.2), subcutaneous fat pad adult (RPKM 106.0) and 2 other tissues See more
Orthologs
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Genomic context

See Orm1 in Genome Data Viewer
Location:
4 B3; 4 33.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63262793..63266400)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63344556..63348163)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62968523-62968632 Neighboring gene STARR-seq mESC enhancer starr_10435 Neighboring gene predicted gene, 52743 Neighboring gene orosomucoid 1 pseudogene Neighboring gene orosomucoid 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immune system process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-1-acid glycoprotein 1
Names
AGP 1
OMD 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008768.2NP_032794.1  alpha-1-acid glycoprotein 1 precursor

    See identical proteins and their annotated locations for NP_032794.1

    Status: REVIEWED

    Source sequence(s)
    AA611123, AK138985, AL683828, AW113734
    Consensus CDS
    CCDS18251.1
    UniProtKB/Swiss-Prot
    Q60590
    UniProtKB/TrEMBL
    Q91X23
    Related
    ENSMUSP00000030044.3, ENSMUST00000030044.3
    Conserved Domains (1) summary
    pfam00061
    Location:43181
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63262793..63266400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)