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OAS3 2'-5'-oligoadenylate synthetase 3 [ Homo sapiens (human) ]

Gene ID: 4940, updated on 4-Dec-2022

Summary

Official Symbol
OAS3provided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase 3provided by HGNC
Primary source
HGNC:HGNC:8088
See related
Ensembl:ENSG00000111331 MIM:603351; AllianceGenome:HGNC:8088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p100; p100OAS
Summary
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in spleen (RPKM 15.4), bone marrow (RPKM 10.1) and 24 other tissues See more
Orthologs
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Genomic context

See OAS3 in Genome Data Viewer
Location:
12q24.13
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112938474..112973251)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112915123..112949876)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113376279..113411056)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene rabphilin 3A Neighboring gene microRNA 1302-1 Neighboring gene Sharpr-MPRA regulatory region 3381 Neighboring gene 2'-5'-oligoadenylate synthetase 1 Neighboring gene 2'-5'-oligoadenylate synthetase 2 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.
EBI GWAS Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
EBI GWAS Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of 2'-5'-oligoadenylate synthetase 3 (OAS3) in human B cells PubMed
Tat tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of OAS3 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133260

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in MDA-5 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of IP-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotactic protein-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
2'-5'-oligoadenylate synthase 3
Names
(2-5')oligo(A) synthase 3
(2-5')oligo(A) synthetase 3
2'-5'-oligoadenylate synthetase 3, 100kDa
2'-5'oligoadenylate synthetase p100
2-5A synthase 3
2-5A synthetase 3
p100 OAS
NP_006178.2
XP_047284862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410984.1NP_001397913.1  2'-5'-oligoadenylate synthase 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004551
    Consensus CDS
    CCDS91756.1
    UniProtKB/TrEMBL
    A0A7P0T8S7
  2. NM_006187.4NP_006178.2  2'-5'-oligoadenylate synthase 3 isoform 1

    See identical proteins and their annotated locations for NP_006178.2

    Status: REVIEWED

    Source sequence(s)
    AB044545, AC004551, AF063613, BC113746
    Consensus CDS
    CCDS44981.1
    UniProtKB/Swiss-Prot
    Q9H3P5, Q9Y6K5
    Related
    ENSP00000228928.7, ENST00000228928.12
    Conserved Domains (2) summary
    cd05400
    Location:769948
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:9031084
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    112938474..112973251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428906.1XP_047284862.1  2'-5'-oligoadenylate synthase 3 isoform X1

    Related
    ENSP00000505225.1, ENST00000681497.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    112915123..112949876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)