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NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 4915, updated on 12-Sep-2017
Official Symbol
NTRK2provided by HGNC
Official Full Name
neurotrophic receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:8032
See related
Ensembl:ENSG00000148053 MIM:600456; Vega:OTTHUMG00000020120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBHD; TRKB; trk-B; GP145-TrkB
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
Location:
9q21.33
Exon count:
23
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (84668368..85027070)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (87283417..87641985)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376116 Neighboring gene solute carrier family 28 member 3 Neighboring gene uncharacterized LOC102724036 Neighboring gene uncharacterized LOC105376118 Neighboring gene uncharacterized LOC107987088

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Obesity, hyperphagia, and developmental delay
MedGen: C3151303 OMIM: 613886 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Variants close to NTRK2 gene are associated with birth weight in female twins.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

Go to the HIV-1, Human Interaction Database

  • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
    Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • BDNF-TrkB Signaling, organism-specific biosystem (from WikiPathways)
    BDNF-TrkB Signaling, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, tran...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • ERK Pathway in Huntington's Disease, organism-specific biosystem (from WikiPathways)
    ERK Pathway in Huntington's Disease, organism-specific biosystemThis ERK pathway is implicated in Huntington's Disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
    NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
brain-derived neurotrophic factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
brain-derived neurotrophic factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotrophin binding IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain-derived neurotrophic factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
learning ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retinal rod cell development IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
BDNF/NT-3 growth factors receptor
Names
BDNF-tropomyosine receptor kinase B
neurotrophic tyrosine kinase receptor type 2
tropomyosin-related kinase B
tyrosine kinase receptor B
NP_001007098.1
NP_001018074.1
NP_001018075.1
NP_001018076.1
NP_001278866.1
NP_006171.2
XP_005252058.1
XP_005252060.1
XP_005252061.1
XP_005252063.1
XP_005252064.1
XP_011517020.1
XP_011517022.1
XP_016870240.1
XP_016870241.1
XP_016870242.1
XP_016870243.1
XP_016870244.1
XP_016870245.1
XP_016870246.1
XP_016870247.1
XP_016870248.1
XP_016870249.1
XP_016870250.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012201.2 RefSeqGene

    Range
    4908..363520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007097.2NP_001007098.1  BDNF/NT-3 growth factors receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001007098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b, also known as TrkB-T1) lacks several 3' exons but contains an alternate 3' terminal exon (exon 16 in PMID:11798182), and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
    Source sequence(s)
    AB209118, AL713745, AL833196, BC031835, BE148667, HY311899
    Consensus CDS
    CCDS35053.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Related
    ENSP00000379221.1, ENST00000395882.5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain
  2. NM_001018064.2NP_001018074.1  BDNF/NT-3 growth factors receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001018074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks an alternate in-frame exon in the central coding region, compared to variant a, resulting in an isoform (c) that is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
    Source sequence(s)
    AK289904, AL445532, BX649001, U12140
    Consensus CDS
    CCDS35050.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2, Q5VWE5
    Related
    ENSP00000314586.4, OTTHUMP00000021573, ENST00000323115.8, OTTHUMT00000052882
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. NM_001018065.2NP_001018075.1  BDNF/NT-3 growth factors receptor isoform d precursor

    See identical proteins and their annotated locations for NP_001018075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (d, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
    Source sequence(s)
    AB209118, AF410901, AL596132
    Consensus CDS
    CCDS35051.1
    UniProtKB/Swiss-Prot
    Q16620
    Related
    ENSP00000306167.6, OTTHUMP00000021575, ENST00000304053.10, OTTHUMT00000052884
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  4. NM_001018066.2NP_001018076.1  BDNF/NT-3 growth factors receptor isoform e precursor

    See identical proteins and their annotated locations for NP_001018076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an alternate in-frame exon in the central coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (e, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern.
    Source sequence(s)
    AB209118, AF410901, AL596132
    Consensus CDS
    CCDS35052.1
    UniProtKB/Swiss-Prot
    Q16620
    Related
    ENSP00000365381.1, OTTHUMP00000021574, ENST00000376208.5, OTTHUMT00000052883
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  5. NM_001291937.1NP_001278866.1  BDNF/NT-3 growth factors receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) uses an alternate in-frame splice site in the central coding region, and lacks several 3' exons but contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL390777, AL713745, AL833196, BC075804, BE148667, DA449367, HY311899
    Conserved Domains (7) summary
    cd05855
    Location:288366
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  6. NM_006180.4NP_006171.2  BDNF/NT-3 growth factors receptor isoform a precursor

    See identical proteins and their annotated locations for NP_006171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a, also known as TrkB) represents the longest transcript and encodes the longest isoform (a). The 5' UTR exon structure is inferred due to a lack of 5'-complete transcript support for this variant.
    Source sequence(s)
    AF410899, AK289904, AL390777, AL445532, BX649001, DA283111, DA449367
    Consensus CDS
    CCDS6671.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230, Q5VWE5
    Related
    ENSP00000365387.1, ENST00000376214.5
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    84668368..85027070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518718.2XP_011517020.1  BDNF/NT-3 growth factors receptor isoform X2

    See identical proteins and their annotated locations for XP_011517020.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. XM_017014751.1XP_016870240.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. XM_017014753.1XP_016870242.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  4. XM_005252001.2XP_005252058.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252058.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  5. XM_005252006.3XP_005252063.1  BDNF/NT-3 growth factors receptor isoform X3

    See identical proteins and their annotated locations for XP_005252063.1

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  6. XM_011518720.2XP_011517022.1  BDNF/NT-3 growth factors receptor isoform X4

    See identical proteins and their annotated locations for XP_011517022.1

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  7. XM_017014760.1XP_016870249.1  BDNF/NT-3 growth factors receptor isoform X5

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain
  8. XM_005252007.3XP_005252064.1  BDNF/NT-3 growth factors receptor isoform X5

    See identical proteins and their annotated locations for XP_005252064.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain
  9. XM_005252003.2XP_005252060.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252060.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  10. XM_017014756.1XP_016870245.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  11. XM_017014759.1XP_016870248.1  BDNF/NT-3 growth factors receptor isoform X5

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain
  12. XM_017014752.1XP_016870241.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Related
    ENSP00000365386.1, ENST00000376213.5
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  13. XM_017014755.1XP_016870244.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  14. XM_017014757.1XP_016870246.1  BDNF/NT-3 growth factors receptor isoform X4

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  15. XM_017014758.1XP_016870247.1  BDNF/NT-3 growth factors receptor isoform X5

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain
  16. XM_005252004.2XP_005252061.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252061.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Related
    ENSP00000277120.3, OTTHUMP00000021576, ENST00000277120.7, OTTHUMT00000052885
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  17. XM_017014754.1XP_016870243.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (7) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  18. XM_017014761.1XP_016870250.1  BDNF/NT-3 growth factors receptor isoform X5

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl28434
    Location:205283
    I-set; Immunoglobulin I-set domain

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    87429880..87788555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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