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NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 4915, updated on 28-Nov-2021

Summary

Official Symbol
NTRK2provided by HGNC
Official Full Name
neurotrophic receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:8032
See related
Ensembl:ENSG00000148053 MIM:600456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 64.6), thyroid (RPKM 30.4) and 3 other tissues See more
Orthologs
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Genomic context

See NTRK2 in Genome Data Viewer
Location:
9q21.33
Exon count:
28
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (84668458..85027070)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (87283437..87641969)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 member 3 Neighboring gene SLC28A3 intron nontranscribed chromatin-defined enhancer Neighboring gene uncharacterized LOC102724036 Neighboring gene uncharacterized LOC105376118 Neighboring gene uncharacterized LOC107987088

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 58
MedGen: C4693367 OMIM: 617830 GeneReviews: Not available
Compare labs
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
GeneReviews: Not available
Obesity, hyperphagia, and developmental delay
MedGen: C3151303 OMIM: 613886 GeneReviews: Not available
Compare labs
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Variants close to NTRK2 gene are associated with birth weight in female twins.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables brain-derived neurotrophic factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables brain-derived neurotrophic factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables brain-derived neurotrophic factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables brain-derived neurotrophic factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables neurotrophin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotrophin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotrophin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neurotrophin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to brain-derived neurotrophic factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in central nervous system neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebral cortex development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuronal action potential propagation IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peripheral nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinal rod cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BDNF/NT-3 growth factors receptor
Names
BDNF-tropomyosine receptor kinase B
neurotrophic tyrosine kinase receptor type 2
tropomyosin-related kinase B
tyrosine kinase receptor B
NP_001007098.1
NP_001018074.1
NP_001018075.1
NP_001018076.1
NP_001278866.1
NP_001356461.1
NP_001356462.1
NP_001356463.1
NP_001356464.1
NP_001356465.1
NP_001356466.1
NP_001356467.1
NP_001356468.1
NP_001356469.1
NP_001356470.1
NP_001356471.1
NP_001356472.1
NP_001356473.1
NP_001356474.1
NP_001356475.1
NP_001356476.1
NP_001356477.1
NP_001356478.1
NP_001356479.1
NP_001356480.1
NP_001356481.1
NP_006171.2
XP_005252058.1
XP_005252060.1
XP_005252061.1
XP_005252063.1
XP_011517020.1
XP_011517022.1
XP_016870240.1
XP_016870241.1
XP_016870242.1
XP_016870244.1
XP_016870249.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012201.2 RefSeqGene

    Range
    6179..363504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007097.3NP_001007098.1  BDNF/NT-3 growth factors receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001007098.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b, also known as TrkB-T1) lacks several 3' exons but contains an alternate 3' terminal exon (exon 16 in PMID:11798182), and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants b and o-w all encode the same isoform (b).
    Source sequence(s)
    AL390777
    Consensus CDS
    CCDS35053.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  2. NM_001018064.3NP_001018074.1  BDNF/NT-3 growth factors receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001018074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) lacks an alternate in-frame exon in the central coding region, compared to variant a, resulting in an isoform (c) that is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants c, k, and l all encode the same isoform (c).
    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS35050.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2, Q5VWE5
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  3. NM_001018065.2NP_001018075.1  BDNF/NT-3 growth factors receptor isoform d precursor

    See identical proteins and their annotated locations for NP_001018075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (d, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants d and m both encode the same isoform (d).
    Source sequence(s)
    AB209118, AF410901, AL596132
    Consensus CDS
    CCDS35051.1
    UniProtKB/Swiss-Prot
    Q16620
    Related
    ENSP00000306167.6, ENST00000304053.10
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  4. NM_001018066.3NP_001018076.1  BDNF/NT-3 growth factors receptor isoform e precursor

    See identical proteins and their annotated locations for NP_001018076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks an alternate in-frame exon in the central coding region, and also lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (e, also known as TrkB-T-Shc) has a distinct C-terminus and is shorter than isoform a. The 5' UTR is incomplete due to a lack of 5'-complete transcript support for this variant, and because there is ambiguity in the 5' UTR splicing pattern. Variants e and n both encode the same isoform (e).
    Source sequence(s)
    AL390777, AL596132
    Consensus CDS
    CCDS35052.1
    UniProtKB/Swiss-Prot
    Q16620
    Related
    ENSP00000365381.1, ENST00000376208.6
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  5. NM_001291937.2NP_001278866.1  BDNF/NT-3 growth factors receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) uses an alternate in-frame splice site in the central coding region, and lacks several 3' exons but contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant a. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a. Variants f and x both encode the same isoform (f).
    Source sequence(s)
    AL390777
    Conserved Domains (6) summary
    cd05855
    Location:288366
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
  6. NM_001369532.1NP_001356461.1  BDNF/NT-3 growth factors receptor isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (k), as well as variants c and l, encodes isoform c.
    Source sequence(s)
    AL390777, AL445532, AL596132
    Related
    ENSP00000314586.4, ENST00000323115.10
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  7. NM_001369533.1NP_001356462.1  BDNF/NT-3 growth factors receptor isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (l), as well as variants c and k, encodes isoform c.
    Source sequence(s)
    AL390777, AL445532, AL596132
    Related
    ENSP00000365386.1, ENST00000376213.6
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  8. NM_001369534.1NP_001356463.1  BDNF/NT-3 growth factors receptor isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Conserved Domains (5) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    cd05093
    Location:520807
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
  9. NM_001369535.1NP_001356464.1  BDNF/NT-3 growth factors receptor isoform i

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Conserved Domains (5) summary
    cd05093
    Location:376663
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    cd00096
    Location:4953
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49127
    Ig; Immunoglobulin domain
    cl15307
    Location:139
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  10. NM_001369536.1NP_001356465.1  BDNF/NT-3 growth factors receptor isoform h

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Conserved Domains (5) summary
    cd05093
    Location:392679
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    cd00096
    Location:4953
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49127
    Ig; Immunoglobulin domain
    cl15307
    Location:139
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  11. NM_001369537.1NP_001356466.1  BDNF/NT-3 growth factors receptor isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (m), as well as variant d, encodes isoform d.
    Source sequence(s)
    AL390777, AL596132
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  12. NM_001369538.1NP_001356467.1  BDNF/NT-3 growth factors receptor isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (n), as well as variant e, encodes isoform e.
    Source sequence(s)
    AL390777, AL596132
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  13. NM_001369539.1NP_001356468.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (o), as well as variants b and p-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  14. NM_001369540.1NP_001356469.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (p), as well as variants b, o, and q-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  15. NM_001369541.1NP_001356470.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (q), as well as variants b, o, p, and r-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  16. NM_001369542.1NP_001356471.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (r), as well as variants b, o-q, and s-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Related
    ENSP00000352906.3, ENST00000359847.4
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  17. NM_001369543.1NP_001356472.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (s), as well as variants b, o-r, and t-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  18. NM_001369544.1NP_001356473.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (t), as well as variants b, o-s, and u-w, encodes isoform b.
    Source sequence(s)
    AL390777
    Related
    ENSP00000379221.1, ENST00000395882.6
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  19. NM_001369545.1NP_001356474.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (u), as well as variants b, o-t, v, and w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  20. NM_001369546.1NP_001356475.1  BDNF/NT-3 growth factors receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (x), as well as variant f, encodes isoform f.
    Source sequence(s)
    AL390777
    Conserved Domains (6) summary
    cd05855
    Location:288366
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
  21. NM_001369547.1NP_001356476.1  BDNF/NT-3 growth factors receptor isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    AL390777
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    cl15307
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam07679
    Location:205283
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
  22. NM_001369548.1NP_001356477.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (v), as well as variants b, o-u, and w, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  23. NM_001369549.1NP_001356478.1  BDNF/NT-3 growth factors receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (w), as well as variants b and o-v, encodes isoform b.
    Source sequence(s)
    AL390777
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  24. NM_001369550.1NP_001356479.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (y), as well as variants z and aa, encodes isoform k.
    Source sequence(s)
    AL390777
    Conserved Domains (4) summary
    cd00096
    Location:4953
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49127
    Ig; Immunoglobulin domain
    cl15307
    Location:139
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  25. NM_001369551.1NP_001356480.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (z), as well as variants y and aa, encodes isoform k.
    Source sequence(s)
    AL390777
    Conserved Domains (4) summary
    cd00096
    Location:4953
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49127
    Ig; Immunoglobulin domain
    cl15307
    Location:139
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  26. NM_001369552.1NP_001356481.1  BDNF/NT-3 growth factors receptor isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (aa), as well as variants y and z, encodes isoform k.
    Source sequence(s)
    AL390777
    Conserved Domains (4) summary
    cd00096
    Location:4953
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:130223
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:49127
    Ig; Immunoglobulin domain
    cl15307
    Location:139
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  27. NM_006180.6NP_006171.2  BDNF/NT-3 growth factors receptor isoform a precursor

    See identical proteins and their annotated locations for NP_006171.2

    Status: REVIEWED

    Source sequence(s)
    AL390777, AL445532, AL596132
    Consensus CDS
    CCDS6671.1
    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230, Q5VWE5
    Related
    ENSP00000277120.3, ENST00000277120.8
    Conserved Domains (6) summary
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    84668458..85027070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014751.2XP_016870240.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (6) summary
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  2. XM_017014753.2XP_016870242.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  3. XM_017014760.2XP_016870249.1  BDNF/NT-3 growth factors receptor isoform X5

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q5VWE5
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  4. XM_005252001.3XP_005252058.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252058.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (6) summary
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  5. XM_011518720.3XP_011517022.1  BDNF/NT-3 growth factors receptor isoform X4

    See identical proteins and their annotated locations for XP_011517022.1

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  6. XM_011518718.3XP_011517020.1  BDNF/NT-3 growth factors receptor isoform X2

    See identical proteins and their annotated locations for XP_011517020.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  7. XM_017014752.1XP_016870241.1  BDNF/NT-3 growth factors receptor isoform X2

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    Q548C2
    Conserved Domains (6) summary
    cd05093
    Location:532819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  8. XM_017014755.1XP_016870244.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  9. XM_005252006.4XP_005252063.1  BDNF/NT-3 growth factors receptor isoform X3

    See identical proteins and their annotated locations for XP_005252063.1

    UniProtKB/Swiss-Prot
    Q16620
    Conserved Domains (7) summary
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:3160
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  10. XM_005252003.3XP_005252060.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252060.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (6) summary
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
  11. XM_005252004.2XP_005252061.1  BDNF/NT-3 growth factors receptor isoform X1

    See identical proteins and their annotated locations for XP_005252061.1

    UniProtKB/Swiss-Prot
    Q16620
    UniProtKB/TrEMBL
    A0A024R230
    Conserved Domains (6) summary
    cd05093
    Location:548835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205283
    Ig; Immunoglobulin domain
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