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ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Homo sapiens (human) ]

Gene ID: 489, updated on 24-Nov-2020

Summary

Official Symbol
ATP2A3provided by HGNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by HGNC
Primary source
HGNC:HGNC:813
See related
Ensembl:ENSG00000074370 MIM:601929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SERCA3
Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 38.6), stomach (RPKM 37.7) and 18 other tissues See more
Orthologs

Genomic context

See ATP2A3 in Genome Data Viewer
Location:
17p13.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3923869..3964464, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3827163..3867758, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene purinergic receptor P2X 1 Neighboring gene long intergenic non-protein coding RNA 1975 Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene RNA, 5S ribosomal pseudogene 434

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with ATPase, Ca++ transporting, ubiquitous (ATP2A3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium transmembrane transporter activity, phosphorylative mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium transmembrane transporter activity, phosphorylative mechanism IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
proton-exporting ATPase activity, phosphorylative mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet dense tubular network membrane TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Names
ATPase, Ca(2+)-transporting, ubiquitous
ATPase, Ca++ transporting, ubiquitous
SR Ca(2+)-ATPase 3
adenosine triphosphatase, calcium
calcium pump 3
calcium-translocating P-type ATPase
sarco/endoplasmic reticulum Ca2+ -ATPase
NP_005164.2
NP_777613.1
NP_777614.1
NP_777615.1
NP_777616.1
NP_777617.1
NP_777618.1
XP_011522183.1
XP_011522184.1
XP_011522186.1
XP_011522187.1
XP_011522190.1
XP_011522191.1
XP_011522194.1
XP_016880181.1
XP_016880182.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029041.1 RefSeqGene

    Range
    5006..45570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005173.4NP_005164.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

    See identical proteins and their annotated locations for NP_005164.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AA643105, AC005940, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS45579.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380234.3, ENST00000397041.8
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  2. NM_174953.3NP_777613.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform e

    See identical proteins and their annotated locations for NP_777613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes two additional exons in the 3' coding region but maintains the reading frame, compared to variant 1. Variant 5 encodes isoform e, which is longer than isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS11042.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000353072.3, ENST00000359983.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  3. NM_174954.3NP_777614.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform d

    See identical proteins and their annotated locations for NP_777614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes two additional exons in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 4 encodes isoform d, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  4. NM_174955.3NP_777615.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

    See identical proteins and their annotated locations for NP_777615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS11041.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000301387.6, ENST00000352011.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  5. NM_174956.3NP_777616.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

    See identical proteins and their annotated locations for NP_777616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS42234.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000312577.7, ENST00000309890.11
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  6. NM_174957.3NP_777617.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform f

    See identical proteins and their annotated locations for NP_777617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in frame splice site in the 3' coding region, compared to variant 1. Variant 6 encodes isoform f, which is one aa shorter than isoform a.
    Source sequence(s)
    AA643105, AC005940, AF068220, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS45580.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380236.3, ENST00000397043.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  7. NM_174958.3NP_777618.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

    See identical proteins and their annotated locations for NP_777618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes an additional exon and uses alternate splices in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 7 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF068221, AK292716, BC035729
    Consensus CDS
    CCDS42234.1
    UniProtKB/Swiss-Prot
    Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380229.3, ENST00000397035.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    3923869..3964464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523885.1XP_011522187.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  2. XM_011523888.2XP_011522190.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  3. XM_011523881.2XP_011522183.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  4. XM_017024693.2XP_016880182.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

  5. XM_011523882.2XP_011522184.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  6. XM_011523884.3XP_011522186.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  7. XM_017024692.1XP_016880181.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

  8. XM_011523889.1XP_011522191.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

    Conserved Domains (6) summary
    TIGR01116
    Location:53989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419528
    Cation_ATPase; Cation transport ATPase (P-type)
  9. XM_011523892.2XP_011522194.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9

    Conserved Domains (3) summary
    pfam00122
    Location:92340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam13246
    Location:419518
    Cation_ATPase; Cation transport ATPase (P-type)
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