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CCN3 cellular communication network factor 3 [ Homo sapiens (human) ]

Gene ID: 4856, updated on 15-Mar-2020

Summary

Official Symbol
CCN3provided by HGNC
Official Full Name
cellular communication network factor 3provided by HGNC
Primary source
HGNC:HGNC:7885
See related
Ensembl:ENSG00000136999 MIM:164958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOV; NOVh; IBP-9; IGFBP9; IGFBP-9
Summary
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
Expression
Biased expression in adrenal (RPKM 648.6) and prostate (RPKM 11.0) See more
Orthologs

Genomic context

See CCN3 in Genome Data Viewer
Location:
8q24.12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (119416446..119424434)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120428552..120436678)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MAL2 antisense RNA 1 Neighboring gene mal, T cell differentiation protein 2 (gene/pseudogene) Neighboring gene microRNA 548az Neighboring gene zinc finger protein 532 pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 2 Neighboring gene CYCS pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
bone regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
gap junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
gap junction ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCN family member 3
Names
IGF-binding protein 9
insulin-like growth factor-binding protein 9
nephro blastoma-overexpressed gene protein homolog
nephroblastoma overexpressed
nephroblastoma-overexpressed gene protein homolog
protein NOV homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009779.1 RefSeqGene

    Range
    5135..13123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002514.4NP_002505.1  CCN family member 3 precursor

    See identical proteins and their annotated locations for NP_002505.1

    Status: REVIEWED

    Source sequence(s)
    AC021733, AY082381, DA162276
    Consensus CDS
    CCDS6328.1
    UniProtKB/Swiss-Prot
    P48745
    UniProtKB/TrEMBL
    A0A024R9J4
    Related
    ENSP00000259526.3, ENST00000259526.4
    Conserved Domains (3) summary
    smart00121
    Location:3395
    IB; Insulin growth factor-binding protein homologues
    smart00041
    Location:269338
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:110170
    VWC; von Willebrand factor (vWF) type C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    119416446..119424434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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