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CCN3 cellular communication network factor 3 [ Homo sapiens (human) ]

Gene ID: 4856, updated on 5-Aug-2022

Summary

Official Symbol
CCN3provided by HGNC
Official Full Name
cellular communication network factor 3provided by HGNC
Primary source
HGNC:HGNC:7885
See related
Ensembl:ENSG00000136999 MIM:164958; AllianceGenome:HGNC:7885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOV; NOVh; IBP-9; IGFBP9; IGFBP-9
Summary
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
Expression
Biased expression in adrenal (RPKM 648.6) and prostate (RPKM 11.0) See more
Orthologs
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Genomic context

See CCN3 in Genome Data Viewer
Location:
8q24.12
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (119416446..119424434)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (120544918..120552906)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120428686..120436674)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 548az Neighboring gene uncharacterized LOC124902009 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene zinc finger protein 532 pseudogene Neighboring gene Sharpr-MPRA regulatory region 15323

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endothelial cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in gap junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in gap junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCN family member 3
Names
IGF-binding protein 9
insulin-like growth factor-binding protein 9
nephro blastoma-overexpressed gene protein homolog
nephroblastoma overexpressed
nephroblastoma-overexpressed gene protein homolog
protein NOV homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009779.1 RefSeqGene

    Range
    5135..13123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002514.4NP_002505.1  CCN family member 3 precursor

    See identical proteins and their annotated locations for NP_002505.1

    Status: REVIEWED

    Source sequence(s)
    AC021733, AY082381, DA162276
    Consensus CDS
    CCDS6328.1
    UniProtKB/Swiss-Prot
    P48745, Q9UDE4
    UniProtKB/TrEMBL
    A0A024R9J4
    Related
    ENSP00000259526.3, ENST00000259526.4
    Conserved Domains (3) summary
    smart00121
    Location:3395
    IB; Insulin growth factor-binding protein homologues
    smart00041
    Location:269338
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:110170
    VWC; von Willebrand factor (vWF) type C domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    119416446..119424434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    120544918..120552906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)