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Ccn3 cellular communication network factor 3 [ Mus musculus (house mouse) ]

Gene ID: 18133, updated on 5-Mar-2024

Summary

Official Symbol
Ccn3provided by MGI
Official Full Name
cellular communication network factor 3provided by MGI
Primary source
MGI:MGI:109185
See related
Ensembl:ENSMUSG00000037362 AllianceGenome:MGI:109185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nov; C130088N23Rik
Summary
Predicted to enable Notch binding activity; heparin binding activity; and integrin binding activity. Involved in several processes, including bone regeneration; negative regulation of cell communication; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CCN3 (cellular communication network factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 83.7), frontal lobe adult (RPKM 20.9) and 4 other tissues See more
Orthologs
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Genomic context

See Ccn3 in Genome Data Viewer
Location:
15 D1; 15 21.49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54609306..54617158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54745910..54753762)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene mal, T cell differentiation protein 2 Neighboring gene STARR-seq mESC enhancer starr_38689 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 57626

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCN family member 3
Names
nephroblastoma overexpressed
nephroblastoma-overexpressed gene protein homolog
novH
protein NOV homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010930.5NP_035060.1  CCN family member 3 precursor

    See identical proteins and their annotated locations for NP_035060.1

    Status: VALIDATED

    Source sequence(s)
    AC129583
    Consensus CDS
    CCDS27471.1
    UniProtKB/Swiss-Prot
    Q64299, Q8CA67
    UniProtKB/TrEMBL
    Q3U2X7
    Related
    ENSMUSP00000054389.9, ENSMUST00000050027.9
    Conserved Domains (3) summary
    smart00121
    Location:2889
    IB; Insulin growth factor-binding protein homologues
    smart00041
    Location:266335
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:104164
    VWC; von Willebrand factor (vWF) type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54609306..54617158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)