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NME2 NME/NM23 nucleoside diphosphate kinase 2 [ Homo sapiens (human) ]

Gene ID: 4831, updated on 6-Jan-2019

Summary

Official Symbol
NME2provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2provided by HGNC
Primary source
HGNC:HGNC:7850
See related
Ensembl:ENSG00000243678 MIM:156491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Summary
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues See more
Orthologs

Genomic context

See NME2 in Genome Data Viewer
Location:
17q21.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (51165435..51171744)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49242796..49249105)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene mbt domain containing 1 Neighboring gene UTP18, small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of NME/NM23 nucleoside diphosphate kinase 2 (NME2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2212, MGC111212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
fatty acid binding IEA
Inferred from Electronic Annotation
more info
 
intermediate filament binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity EXP
Inferred from Experiment
more info
PubMed 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myeloid leukocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-histidine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to growth hormone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
NOT focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nucleoside diphosphate kinase B
Names
HEL-S-155an
NDP kinase B
c-myc purine-binding transcription factor PUF
c-myc transcription factor
epididymis secretory sperm binding protein Li 155an
histidine protein kinase NDKB
non-metastatic cells 2, protein (NM23) expressed in
non-metastatic cells 2, protein (NM23B) expressed in
nucleotide diphosphate kinase B
NP_001018147.1
NP_001018148.1
NP_001018149.1
NP_001185611.1
NP_002503.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018137.2NP_001018147.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    CA307456, CK023920
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    P22392
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000426976.2, ENST00000514264.6
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  2. NM_001018138.1NP_001018148.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC002476, BF058708
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    P22392
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000376886.1, ENST00000393190.4
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  3. NM_001018139.2NP_001018149.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BM556410
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    P22392
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000426901.1, ENST00000503064.5
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  4. NM_001198682.1NP_001185611.1  nucleoside diphosphate kinase B isoform b

    See identical proteins and their annotated locations for NP_001185611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    CB242387, CN267160, DB454073
    Consensus CDS
    CCDS74107.1
    UniProtKB/TrEMBL
    F6XY72
    Related
    ENSP00000376880.4, ENST00000393183.7
    Conserved Domains (2) summary
    cl00335
    Location:576
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    pfam00334
    Location:577
    NDK; Nucleoside diphosphate kinase
  5. NM_002512.3NP_002503.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_002503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.
    Source sequence(s)
    BC095458, BF034471, DB454073
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    P22392
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000421064.1, ENST00000512737.5
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    51165435..51171744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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