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NME1-NME2 NME1-NME2 readthrough [ Homo sapiens (human) ]

Gene ID: 654364, updated on 5-Sep-2021

Summary

Official Symbol
NME1-NME2provided by HGNC
Official Full Name
NME1-NME2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33531
See related
Ensembl:ENSG00000011052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMELV; NM23-LV
Summary
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 115.4), ovary (RPKM 91.9) and 25 other tissues See more
Orthologs
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Genomic context

See NME1-NME2 in Genome Data Viewer
Location:
17q21.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (51153559..51171744)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49230920..49249105)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371825 Neighboring gene sperm associated antigen 9 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1 Neighboring gene UTP18 small subunit processome component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough NME1-NME2

Included genes: NME1, NME2

Homology

Clone Names

  • FLJ93990

General protein information

Preferred Names
NME1-NME2 protein
Names
NME1-NME2 readthrough transcript
NP_001018146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018136.3NP_001018146.1  NME1-NME2 protein

    See identical proteins and their annotated locations for NP_001018146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AC005839, BC133029, DQ109675
    Consensus CDS
    CCDS32682.1
    UniProtKB/Swiss-Prot
    P22392
    Related
    ENSP00000376889.2, ENST00000393193.6
    Conserved Domains (4) summary
    PTZ00093
    Location:118266
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
    smart00562
    Location:5114
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04413
    Location:5114
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    pfam00334
    Location:120254
    NDK; Nucleoside diphosphate kinase

RNA

  1. NR_037149.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF may render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005839, BC107894, DQ109675
    Related
    ENST00000555572.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    51153559..51171744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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