SFRP1 secreted frizzled related protein 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SFRP1provided by VGNC
Official Full Name: secreted frizzled related protein 1provided by VGNC
Primary source: VGNC:VGNC:46080
See related: Ensembl:ENSCAFG00845008758
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: FrzA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (26010215..26053984)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (24766734..24810532)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (24995596..25039359)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (24382043..24425801)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (24943898..24987804)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis.
Title: MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: secreted frizzled-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051820.1 Reference ROS_Cfam_1.0

Range

26010215..26053984

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038689771.1 → XP_038545699.1 secreted frizzled-related protein 1

UniProtKB/TrEMBL

A0A8C0JP54, A0A8C0QEZ7, A0A8I3N6M9

Related

ENSCAFP00845011939.1, ENSCAFT00845015374.1

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049276.1 Alternate UMICH_Zoey_3.1

Range

24382043..24425801

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038497519.1 → XP_038353447.1 secreted frizzled-related protein 1

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049757.1 Alternate UNSW_CanFamBas_1.0

Range

24943898..24987804

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038624008.1 → XP_038479936.1 secreted frizzled-related protein 1

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049237.1 Alternate UU_Cfam_GSD_1.0

Range

24995596..25039359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038559971.1 → XP_038415899.1 secreted frizzled-related protein 1

UniProtKB/TrEMBL

A0A8C0JP54, A0A8C0QEZ7, A0A8I3N6M9

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

24766734..24810532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003639564.3 → XP_003639612.2 secreted frizzled-related protein 1

UniProtKB/TrEMBL

A0A8C0JP54, A0A8C0QEZ7, A0A8I3N6M9

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...