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SFRP1 secreted frizzled related protein 1 [ Homo sapiens (human) ]

Gene ID: 6422, updated on 11-Jun-2025
Official Symbol
SFRP1provided by HGNC
Official Full Name
secreted frizzled related protein 1provided by HGNC
Primary source
HGNC:HGNC:10776
See related
Ensembl:ENSG00000104332 MIM:604156; AllianceGenome:HGNC:10776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRP; FRP1; FrzA; FRP-1; SARP2
Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Expression
Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues See more
Orthologs
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See SFRP1 in Genome Data Viewer
Location:
8p11.21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41261962..41309473, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41535586..41583179, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41119481..41166992, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 356, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr8:40915338-40915839 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:40930517-40931040 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:40932557-40933440 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:41008706-41009905 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:41013787-41014986 Neighboring gene uncharacterized LOC105379771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41052497-41053016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41053017-41053536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27281 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41133705-41134289 Neighboring gene microRNA 548ao Neighboring gene ribosomal protein S29 pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:41165170-41165941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41165942-41166712 Neighboring gene NANOG hESC enhancer GRCh37_chr8:41168632-41169159 Neighboring gene RNA, U6 small nuclear 895, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41179229-41179970 Neighboring gene Sharpr-MPRA regulatory region 9460 Neighboring gene uncharacterized LOC105379391 Neighboring gene uncharacterized LOC124901938 Neighboring gene small nucleolar RNA, C/D box 65B

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of secreted frizzled-related protein 1 (SFRP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 has the ability to induce expression of FRP-1 on peripheral blood mononuclear cells (PBMC) PubMed
Envelope surface glycoprotein gp160, precursor env Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160 PubMed
env Co-cultivation of PBMC with HIV-1 gp160-expressing HeLa cells results in the increased expression of FRP-1 on T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to BMP stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to X-ray IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estrogen stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to prostaglandin E stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within development of primary male sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal/ventral axis specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within female gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neural crest cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube development IEA
Inferred from Electronic Annotation
more info
 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regionalization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of planar polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of midbrain dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somitogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
secreted frizzled-related protein 1
Names
SARP-2
frizzled-related protein
sFRP-1
secreted apoptosis-related protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003012.5NP_003003.3  secreted frizzled-related protein 1 precursor

    See identical proteins and their annotated locations for NP_003003.3

    Status: REVIEWED

    Source sequence(s)
    AC104393, BC036503, BQ002015, CB956696, CN271890, DA571541
    Consensus CDS
    CCDS34886.1
    UniProtKB/Swiss-Prot
    O00546, O14779, Q8N474
    UniProtKB/TrEMBL
    A8KAM5
    Related
    ENSP00000220772.3, ENST00000220772.8
    Conserved Domains (2) summary
    cd07443
    Location:52175
    CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
    cd03580
    Location:183306
    NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    41261962..41309473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    41535586..41583179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)