SFRP1 secreted frizzled related protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SFRP1provided by HGNC
Official Full Name: secreted frizzled related protein 1provided by HGNC
Primary source: HGNC:HGNC:10776
See related: Ensembl:ENSG00000104332 MIM:604156
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FRP; FRP1; FrzA; FRP-1; SARP2
Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Expression: Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	8	NC_000008.11 (41261962..41309473, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (41119481..41166992, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-risk HPV infection modulates the promoter hypermethylation of APC, SFRP1, and PTEN in cervical cancer patients of North India.
Title: High-risk HPV infection modulates the promoter hypermethylation of APC, SFRP1, and PTEN in cervical cancer patients of North India.
Wnt antagonist secreted frizzled-related protein I (sFRP1) may be involved in the osteogenic differentiation of periodontal ligament cells in chronic apical periodontitis.
Title: Wnt antagonist secreted frizzled-related protein I (sFRP1) may be involved in the osteogenic differentiation of periodontal ligament cells in chronic apical periodontitis.
Effects of Secreted frizzled-related protein 1 on inhibiting cardiac remodeling.
Title: Effects of Secreted frizzled-related protein 1 on inhibiting cardiac remodeling.
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Title: Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment.
Title: Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment.
SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers.
Title: SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers.
[sFRP1 Expression Induces miRNAs That Modulate Wnt Signaling in Chronic Myeloid Leukemia Cells].
Title: [sFRP1 Expression Induces miRNAs That Modulate Wnt Signaling in Chronic Myeloid Leukemia Cells].
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence.
Title: Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence.
SFRP1 promotor methylation analysis of FTA card touch-prep samples derived from colonic polyps.
Title: SFRP1 promotor methylation analysis of FTA card touch-prep samples derived from colonic polyps.
Findings suggest that silencing miR-27a dampens osteosarcoma progression, which might be achieved through the inactivation of the Wnt/beta-catenin signaling pathway by up-regulating secreted frizzled related protein 1 (SFRP1).
Title: Silencing microRNA-27a inhibits proliferation and invasion of human osteosarcoma cells through the SFRP1-dependent Wnt/β-catenin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (178)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of secreted frizzled-related protein 1 (SFRP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 has the ability to induce expression of FRP-1 on peripheral blood mononuclear cells (PBMC)	PubMed
Envelope surface glycoprotein gp160, precursor	env	Antibodies raised against the human fusion regulatory protein 1 (FRP-1; CD98) molecule suppress cell fusion mediated by HIV-1 gp160	PubMed
	env	Co-cultivation of PBMC with HIV-1 gp160-expressing HeLa cells results in the increased expression of FRP-1 on T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-105250 (e-PCR)
- UniSTS:169252

SHGC-79057 (e-PCR)
- UniSTS:95880

SFRP1_1897 (e-PCR)
- UniSTS:280993

G19941 (e-PCR)
- UniSTS:36269

A002C42 (e-PCR)
- UniSTS:36270

G43220 (e-PCR)
- UniSTS:94897

RH12508 (e-PCR)
- UniSTS:49333

Homology

Homologs of the SFRP1 gene: The SFRP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 263 organisms have orthologs with human gene SFRP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt-protein binding	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway involved in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in bone trabecula formation	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heparin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in convergent extension involved in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in female gonad development	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JUN kinase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of planar cell polarity pathway involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in response to drug	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in stromal-epithelial cell signaling involved in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: secreted frizzled-related protein 1

Names: SARP-2; frizzled-related protein; sFRP-1; secreted apoptosis-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003012.5 → NP_003003.3 secreted frizzled-related protein 1 precursor

See identical proteins and their annotated locations for NP_003003.3

Status: REVIEWED

Source sequence(s)

AC104393, BC036503, BQ002015, CB956696, CN271890, DA571541

Consensus CDS

CCDS34886.1

UniProtKB/Swiss-Prot

Q8N474

Related

ENSP00000220772.3, ENST00000220772.8

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...