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NKTR natural killer cell triggering receptor [ Homo sapiens (human) ]

Gene ID: 4820, updated on 7-Dec-2018

Summary

Official Symbol
NKTRprovided by HGNC
Official Full Name
natural killer cell triggering receptorprovided by HGNC
Primary source
HGNC:HGNC:7833
See related
Ensembl:ENSG00000114857 MIM:161565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p104
Summary
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See NKTR in Genome Data Viewer
Location:
3p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (42600007..42648741)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42642147..42690233)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene SS18 like 2 Neighboring gene uncharacterized LOC101928323 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene RNA, 7SL, cytoplasmic 567, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of natural killer-tumor recognition sequence (NKTR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC90527, DKFZp686F1754, DKFZp686G0426, DKFZp686J06106, DKFZp686N24126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
NK-tumor recognition protein
Names
NK-TR protein
PPIase
natural killer triggering receptor
natural killer-tumor recognition sequence
natural-killer cells cyclophilin-related protein
peptidyl-prolyl cis-trans isomerase NKTR
rotamase
NP_001336053.1
NP_001336054.1
NP_001336055.1
NP_005376.2
XP_006713234.1
XP_006713236.1
XP_011532049.1
XP_016861963.1
XP_016861964.1
XP_016861965.1
XP_016861966.1
XP_024309307.1
XP_024309308.1
XP_024309309.1
XP_024309311.1
XP_024309312.1
XP_024309313.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349124.1NP_001336053.1  NK-tumor recognition protein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC006059, AC092047
    Conserved Domains (1) summary
    cl00197
    Location:7174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. NM_001349125.1NP_001336054.1  NK-tumor recognition protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c.
    Source sequence(s)
    AC006059, AC092047
  3. NM_001349126.1NP_001336055.1  NK-tumor recognition protein isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate exons and uses two alternate splice junctions compared to variant 3. The resulting isoform (e) is shorter at the N-terminus and lacks a single internal aa compared to isoform c.
    Source sequence(s)
    AC006059, AC092047
  4. NM_005385.4NP_005376.2  NK-tumor recognition protein isoform a

    See identical proteins and their annotated locations for NP_005376.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is 1 aa shorter compared to isoform c.
    Source sequence(s)
    AA493639, L04288
    Consensus CDS
    CCDS2702.1
    UniProtKB/Swiss-Prot
    P30414
    UniProtKB/TrEMBL
    A0A024R2N6
    Related
    ENSP00000232978.8, ENST00000232978.12
    Conserved Domains (2) summary
    pfam09528
    Location:7861161
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cl00197
    Location:7174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    42600007..42648741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453539.1XP_024309307.1  NK-tumor recognition protein isoform X1

    Conserved Domains (1) summary
    cl00197
    Location:7174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. XM_017006474.2XP_016861963.1  NK-tumor recognition protein isoform X3

  3. XM_006713171.2XP_006713234.1  NK-tumor recognition protein isoform X2

    Conserved Domains (1) summary
    cl00197
    Location:7174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  4. XM_006713173.2XP_006713236.1  NK-tumor recognition protein isoform X4

    See identical proteins and their annotated locations for XP_006713236.1

    Conserved Domains (1) summary
    pfam00160
    Location:163
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
  5. XM_024453541.1XP_024309309.1  NK-tumor recognition protein isoform X5

  6. XM_024453544.1XP_024309312.1  NK-tumor recognition protein isoform X7

  7. XM_017006477.2XP_016861966.1  NK-tumor recognition protein isoform X6

  8. XM_024453543.1XP_024309311.1  NK-tumor recognition protein isoform X7

  9. XM_024453540.1XP_024309308.1  NK-tumor recognition protein isoform X4

    Conserved Domains (1) summary
    pfam00160
    Location:163
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
  10. XM_017006475.1XP_016861964.1  NK-tumor recognition protein isoform X5

    Related
    ENSP00000482143.1, ENST00000617821.4
  11. XM_017006476.2XP_016861965.1  NK-tumor recognition protein isoform X6

  12. XM_011533747.3XP_011532049.1  NK-tumor recognition protein isoform X5

    See identical proteins and their annotated locations for XP_011532049.1

  13. XM_024453545.1XP_024309313.1  NK-tumor recognition protein isoform X7

RNA

  1. XR_002959537.1 RNA Sequence

  2. XR_940429.2 RNA Sequence

    Related
    ENST00000429888.5
  3. XR_940430.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012651.1: Suppressed sequence

    Description
    NM_001012651.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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