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Nktr natural killer tumor recognition sequence [ Mus musculus (house mouse) ]

Gene ID: 18087, updated on 7-Apr-2025

Summary

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Official Symbol
Nktrprovided by MGI
Official Full Name
natural killer tumor recognition sequenceprovided by MGI
Primary source
MGI:MGI:97346
See related
Ensembl:ENSMUSG00000032525 AllianceGenome:MGI:97346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Wsu172e; 5330401F18Rik
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in extraembryonic component. Orthologous to human NKTR (natural killer cell triggering receptor). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in limb E14.5 (RPKM 21.4), CNS E14 (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nktr in Genome Data Viewer
Location:
9 F4; 9 72.57 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121542244..121585908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121713881..121756842)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene STARR-positive B cell enhancer mm9_chr9:121606658-121606959 Neighboring gene STARR-positive B cell enhancer ABC_E11426 Neighboring gene STARR-positive B cell enhancer ABC_E1400 Neighboring gene STARR-positive B cell enhancer ABC_E10593 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 2 Neighboring gene RIKEN cDNA E530011L22 gene Neighboring gene STARR-positive B cell enhancer ABC_E6812 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mouse Nktr gene and promoter. Simons-Evelyn M, et al. Genomics, 1997 Feb 15. PMID 9070924
  2. A cyclophilin-related protein involved in the function of natural killer cells. Anderson SK, et al. Proc Natl Acad Sci U S A, 1993 Jan 15. PMID 8421688, Free PMC Article
  3. Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor. Hashimoto H, et al. Genomics, 1999 May 15. PMID 10331949
  4. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. Young HA, et al. Genomics, 1993 May. PMID 8314596
  5. Genetic structure and chromosomal mapping of MyD88. Hardiman G, et al. Genomics, 1997 Oct 15. PMID 9344657

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NK-tumor recognition protein
Names
NK-TR protein
PPIase
cyclophilin-related protein
natural killer tumor recognition protein
natural-killer cells cyclophilin-related protein
peptidyl-prolyl cis-trans isomerase NKTR
NP_035048.3
XP_006512041.1
XP_011241241.2
XP_030099969.1
XP_030099970.1
XP_030099972.1
XP_030099973.1
XP_030099974.1
XP_030099975.1
XP_030099976.1
XP_030099979.1
XP_030099980.1
XP_030099981.1
XP_030099982.1
XP_036010573.1
XP_036010574.1
XP_036010575.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010918.3 → NP_035048.3  NK-tumor recognition protein

    See identical proteins and their annotated locations for NP_035048.3

    Status: VALIDATED

    Source sequence(s)
    AC159810, AC165080
    Consensus CDS
    CCDS23636.1
    UniProtKB/Swiss-Prot
    F8VPR8, P30415, Q3UNH0
    Related
    ENSMUSP00000035112.6, ENSMUST00000035112.13
    Conserved Domains (1) summary
    cl00197
    Location:7 → 174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121542244..121585908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244109.2 → XP_030099969.1  NK-tumor recognition protein isoform X1

    Conserved Domains (1) summary
    cl00197
    Location:109 → 276
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  2. XM_011242939.4 → XP_011241241.2  NK-tumor recognition protein isoform X2

    Conserved Domains (1) summary
    cl00197
    Location:109 → 276
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  3. XM_030244110.2 → XP_030099970.1  NK-tumor recognition protein isoform X4

    Conserved Domains (1) summary
    cl00197
    Location:109 → 240
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  4. XM_036154680.1 → XP_036010573.1  NK-tumor recognition protein isoform X3

    Conserved Domains (1) summary
    cl00197
    Location:109 → 276
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  5. XM_030244122.2 → XP_030099982.1  NK-tumor recognition protein isoform X10

    Conserved Domains (1) summary
    cl00197
    Location:130 → 220
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  6. XM_030244120.2 → XP_030099980.1  NK-tumor recognition protein isoform X7

  7. XM_030244114.2 → XP_030099974.1  NK-tumor recognition protein isoform X5

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  8. XM_030244112.2 → XP_030099972.1  NK-tumor recognition protein isoform X5

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  9. XM_036154681.1 → XP_036010574.1  NK-tumor recognition protein isoform X7

  10. XM_030244116.2 → XP_030099976.1  NK-tumor recognition protein isoform X6

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  11. XM_006511978.3 → XP_006512041.1  NK-tumor recognition protein isoform X5

    See identical proteins and their annotated locations for XP_006512041.1

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  12. XM_030244113.2 → XP_030099973.1  NK-tumor recognition protein isoform X5

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  13. XM_030244115.2 → XP_030099975.1  NK-tumor recognition protein isoform X5

    Conserved Domains (1) summary
    pfam00160
    Location:1 → 63
    Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

  14. XM_030244119.2 → XP_030099979.1  NK-tumor recognition protein isoform X7

  15. XM_030244121.2 → XP_030099981.1  NK-tumor recognition protein isoform X8

  16. XM_036154682.1 → XP_036010575.1  NK-tumor recognition protein isoform X9

RNA

  1. XR_003947811.2 RNA Sequence

  2. XR_004935337.1 RNA Sequence

  3. XR_003947812.2 RNA Sequence

  4. XR_871176.2 RNA Sequence

  5. XR_871177.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30415.4 GenPept UniProtKB/Swiss-Prot:P30415

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