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NGF nerve growth factor [ Homo sapiens (human) ]

Gene ID: 4803, updated on 7-Jun-2020

Summary

Official Symbol
NGFprovided by HGNC
Official Full Name
nerve growth factorprovided by HGNC
Primary source
HGNC:HGNC:7808
See related
Ensembl:ENSG00000134259 MIM:162030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGFB; HSAN5; Beta-NGF
Summary
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 1.3), heart (RPKM 0.5) and 18 other tissues See more
Orthologs

Genomic context

See NGF in Genome Data Viewer
Location:
1p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (115285915..115338253, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115828537..115880857, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 2 Neighboring gene long intergenic non-protein coding RNA 1765 Neighboring gene NGF antisense RNA 1 Neighboring gene uncharacterized LOC112268234 Neighboring gene uncharacterized LOC112268287

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
NHGRI GWA Catalog
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of NGFB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat Nerve growth factor synergizes with HIV-1 Tat to induce HIV-1 gene expression in neuronal and glial cell lines PubMed
tat Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter PubMed
tat HIV-1 Tat shows the ability to inhibit the nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells PubMed
Vpr vpr Treatment of cultured dorsal root ganglion sensory neurons with HIV-1 Vpr downregulates expression of TrKA and pGSK3beta/GSK3beta proteins and pre-treatment with NGF inhibits this Vpr-induced downregulation of TrKA and pGSK3beta/GSK3beta PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC161426, MGC161428

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of MAPKK activity TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor processing TAS
Traceable Author Statement
more info
 
nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of axonogenesis TAS
Traceable Author Statement
more info
 
positive regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome lumen IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
beta-nerve growth factor
Names
nerve growth factor (beta polypeptide)
nerve growth factor, beta subunit
pro-nerve growth factor long

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007944.1 RefSeqGene

    Range
    5001..57321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_260

mRNA and Protein(s)

  1. NM_002506.3NP_002497.2  beta-nerve growth factor precursor

    See identical proteins and their annotated locations for NP_002497.2

    Status: REVIEWED

    Source sequence(s)
    AL512638, BC032517, BE045524, CR541855, X52599
    Consensus CDS
    CCDS882.1
    UniProtKB/Swiss-Prot
    P01138
    Related
    ENSP00000358525.2, ENST00000369512.3
    Conserved Domains (1) summary
    pfam00243
    Location:128237
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    115285915..115338253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710663.3XP_006710726.1  beta-nerve growth factor isoform X2

    See identical proteins and their annotated locations for XP_006710726.1

    UniProtKB/Swiss-Prot
    P01138
    Conserved Domains (1) summary
    pfam00243
    Location:128237
    NGF; Nerve growth factor family
  2. XM_011541518.2XP_011539820.1  beta-nerve growth factor isoform X1

    Conserved Domains (1) summary
    pfam00243
    Location:183291
    NGF; Nerve growth factor family
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