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Ngf nerve growth factor [ Mus musculus (house mouse) ]

Gene ID: 18049, updated on 13-Feb-2024

Summary

Official Symbol
Ngfprovided by MGI
Official Full Name
nerve growth factorprovided by MGI
Primary source
MGI:MGI:97321
See related
Ensembl:ENSMUSG00000027859 AllianceGenome:MGI:97321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngfb; beta-NGF
Summary
Enables transmembrane receptor protein tyrosine kinase activator activity. Involved in positive regulation of DNA binding activity; positive regulation of Ras protein signal transduction; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 9.7), subcutaneous fat pad adult (RPKM 5.1) and 20 other tissues See more
Orthologs
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Genomic context

See Ngf in Genome Data Viewer
Location:
3 F2.2; 3 45.25 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102377235..102428329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102469919..102521013)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40110 Neighboring gene predicted gene, 33679 Neighboring gene STARR-seq mESC enhancer starr_08573 Neighboring gene predicted gene, 46818 Neighboring gene STARR-seq mESC enhancer starr_08574 Neighboring gene STARR-seq mESC enhancer starr_08575 Neighboring gene STARR-seq mESC enhancer starr_08576 Neighboring gene STARR-seq mESC enhancer starr_08577 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene predicted gene, 40112

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables death receptor agonist activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nerve growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to acid chemical IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nerve growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nerve growth factor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of collateral sprouting IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
beta-nerve growth factor
Names
nerve growth factor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112698.2NP_001106168.1  beta-nerve growth factor isoform B precursor

    See identical proteins and their annotated locations for NP_001106168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region compared to variant 1. The resulting isoform (B) has a shorter N-terminus compared to isoform A.
    Source sequence(s)
    AC108822
    Consensus CDS
    CCDS51025.1
    UniProtKB/Swiss-Prot
    P01139, Q63864, Q6LDB7
    Related
    ENSMUSP00000040345.4, ENSMUST00000035952.5
    Conserved Domains (1) summary
    pfam00243
    Location:128237
    NGF; Nerve growth factor family
  2. NM_013609.3NP_038637.1  beta-nerve growth factor isoform A

    See identical proteins and their annotated locations for NP_038637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK144588, BF786523, K01759
    Consensus CDS
    CCDS17687.1
    UniProtKB/TrEMBL
    A0A0G2JEK0, Q6LDU8
    Related
    ENSMUSP00000102538.3, ENSMUST00000106925.9
    Conserved Domains (1) summary
    pfam00243
    Location:194302
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    102377235..102428329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501108.5XP_006501171.1  beta-nerve growth factor isoform X1

    See identical proteins and their annotated locations for XP_006501171.1

    UniProtKB/TrEMBL
    A0A0G2JEK0, Q6LDU8
    Conserved Domains (1) summary
    pfam00243
    Location:194302
    NGF; Nerve growth factor family