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TXNRD1 thioredoxin reductase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 474536, updated on 25-Jul-2026
Official Symbol
TXNRD1provided by VGNC
Official Full Name
thioredoxin reductase 1provided by VGNC
Primary source
VGNC:VGNC:48021
See related
Ensembl:ENSCAFG00845006566 RGD:12321639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See TXNRD1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (34747423..34864919, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (33824269..33941521, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (34960435..35077894, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (34482294..34599587, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (34765845..34883396, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene uncharacterized LOC102151808 Neighboring gene uncharacterized LOC102152060 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene NHP2-like protein 1 Neighboring gene sosondowah ankyrin repeat domain family member C

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glutathione-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
thioredoxin reductase 1, cytoplasmic
NP_001116145.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122673.2 → NP_001116145.1  thioredoxin reductase 1, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000358
    UniProtKB/TrEMBL
    A0A8I3RUW0
    Related
    ENSCAFP00845009152.1, ENSCAFT00845011723.1
    Conserved Domains (4) summary
    TIGR01438
    Location:167 → 655
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:348 → 424
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:527 → 637
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl00388
    Location:73 → 152
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    34747423..34864919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    34482294..34599587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    34765845..34883396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    34960435..35077894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33824269..33941521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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