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LRRC37A2 leucine rich repeat containing 37 member A2 [ Homo sapiens (human) ]

Gene ID: 474170, updated on 3-Sep-2021

Summary

Official Symbol
LRRC37A2provided by HGNC
Official Full Name
leucine rich repeat containing 37 member A2provided by HGNC
Primary source
HGNC:HGNC:32404
See related
Ensembl:ENSG00000238083 MIM:616556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37
Expression
Broad expression in testis (RPKM 18.7), bone marrow (RPKM 5.7) and 23 other tissues See more
Orthologs
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Genomic context

See LRRC37A2 in Genome Data Viewer
Location:
17q21.31-q21.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (46512710..47049128)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44590076..44633014)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene ADP ribosylation factor like GTPase 17A Neighboring gene RNA, 7SL, cytoplasmic 199, pseudogene Neighboring gene RDM1 pseudogene 2 Neighboring gene family with sequence similarity 215 member B Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene vesicle-associated membrane protein 5-like Neighboring gene Sharpr-MPRA regulatory region 12503 Neighboring gene ZFP161 motif-containing MPRA enhancer 249 Neighboring gene ribosomal protein S7 pseudogene 11 Neighboring gene uncharacterized LOC101929777 Neighboring gene Wnt family member 3 Neighboring gene Wnt family member 9B Neighboring gene uncharacterized LOC112268191 Neighboring gene long intergenic non-protein coding RNA 1974 Neighboring gene RNA, U6atac small nuclear 3, pseudogene Neighboring gene uncharacterized LOC101927060 Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene microRNA 5089 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene reprimo like Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene protein GVQW1-like Neighboring gene cell division cycle 27 Neighboring gene ribosomal protein S2 pseudogene 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45049

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 37A2
Names
c114 SLIT-like testicular protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006607.3NP_001006608.2  leucine-rich repeat-containing protein 37A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001006608.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138645
    Consensus CDS
    CCDS42353.1
    UniProtKB/Swiss-Prot
    A6NM11
    UniProtKB/TrEMBL
    Q5YKG5
    Related
    ENSP00000459551.1, ENST00000576629.5
    Conserved Domains (5) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  2. NM_001385803.1NP_001372732.1  leucine-rich repeat-containing protein 37A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC138645
    Conserved Domains (7) summary
    COG4886
    Location:8661045
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    PRK10263
    Location:206704
    PRK10263; DNA translocase FtsK; Provisional
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    NF033395
    Location:113266
    fibronec_SfbI; fibronectin-binding protein SfbI
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:560629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    46512710..47049128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450773.1XP_024306541.1  leucine-rich repeat-containing protein 37A2 isoform X6

    Conserved Domains (5) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681602
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:571629
    LRRC37; Leucine-rich repeat-containing protein 37 family
    cl28087
    Location:144704
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. XM_011524843.3XP_011523145.1  leucine-rich repeat-containing protein 37A2 isoform X3

    Conserved Domains (5) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14191564
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  3. XM_011524841.3XP_011523143.1  leucine-rich repeat-containing protein 37A2 isoform X1

    Conserved Domains (5) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892952
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14441589
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  4. XM_011524844.3XP_011523146.1  leucine-rich repeat-containing protein 37A2 isoform X4

    Conserved Domains (5) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:914956
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:868925
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14171562
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  5. XM_011524848.3XP_011523150.1  leucine-rich repeat-containing protein 37A2 isoform X7

    Conserved Domains (4) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:868920
    LRR_8; Leucine rich repeat
    pfam14914
    Location:13681513
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  6. XM_011524846.3XP_011523148.1  leucine-rich repeat-containing protein 37A2 isoform X5

    Conserved Domains (3) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam14914
    Location:13931538
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  7. XM_011524842.3XP_011523144.1  leucine-rich repeat-containing protein 37A2 isoform X2

    Conserved Domains (5) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681578
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  8. XM_011524849.2XP_011523151.1  leucine-rich repeat-containing protein 37A2 isoform X8

    Conserved Domains (4) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  9. XM_011524850.3XP_011523152.1  leucine-rich repeat-containing protein 37A2 isoform X9

    Conserved Domains (4) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family
  10. XM_024450774.1XP_024306542.1  leucine-rich repeat-containing protein 37A2 isoform X10

    Conserved Domains (4) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:892944
    LRR_8; Leucine rich repeat
    pfam15779
    Location:571629
    LRRC37; Leucine-rich repeat-containing protein 37 family
    cl26557
    Location:223593
    RNase_E_G; Ribonuclease E/G family
  11. XM_024450775.1XP_024306543.1  leucine-rich repeat-containing protein 37A2 isoform X11

    Conserved Domains (3) summary
    sd00031
    Location:868890
    LRR_1; leucine-rich repeat [structural motif]
    pfam15779
    Location:571629
    LRRC37; Leucine-rich repeat-containing protein 37 family
    cl26557
    Location:223579
    RNase_E_G; Ribonuclease E/G family

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    195713..238676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1032391..1075353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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