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Conserved domains on  [gi|767994885|ref|XP_011523152|]
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leucine-rich repeat-containing protein 37A2 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 7.03e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 78.94  E-value: 7.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994885  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779   1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.31e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.31e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 206-704 4.67e-12

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 70.50  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994885  634 TIVSPKHPEVTLPHPDQVQTQHSHLTRATVqpldlgftITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQPVAPQPQDTL--------LHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 3.40e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 54.29  E-value: 3.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767994885  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779  23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
 
Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 7.03e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 78.94  E-value: 7.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994885  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779   1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.31e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.31e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 4.67e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 70.50  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994885  634 TIVSPKHPEVTLPHPDQVQTQHSHLTRATVqpldlgftITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQPVAPQPQDTL--------LHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 2.83e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 60.07  E-value: 2.83e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994885  251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 3.40e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 54.29  E-value: 3.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767994885  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779  23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-953 2.22e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886  116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190


                 ....*...
gi 767994885 946 CNVITELS 953
Cdd:COG4886  191 NNQITDLP 198
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 894-950 2.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767994885 894 LILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIER--HTFEPLPFLKFINLSCNVIT 950
Cdd:cd21340  125 LNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
 
Name Accession Description Interval E-value
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 7.03e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 78.94  E-value: 7.03e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994885  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779   1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 3.31e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 3.31e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 4.67e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 70.50  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767994885  634 TIVSPKHPEVTLPHPDQVQTQHSHLTRATVqpldlgftITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQPVAPQPQDTL--------LHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 2.83e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 60.07  E-value: 2.83e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767994885  251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 352-429 8.78e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 58.53  E-value: 8.78e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885  352 EHELSISEQQQPVQPSESPREVEssptqqetpGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVV---------AQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 3.40e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 54.29  E-value: 3.40e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767994885  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779  23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
914-967 5.66e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.66e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767994885  914 SLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLH 967
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLD 55
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-953 2.22e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886  116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190


                 ....*...
gi 767994885 946 CNVITELS 953
Cdd:COG4886  191 NNQITDLP 198
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-752 2.81e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  190 PYPGSLPPELRVKS-------DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPqlleeePSSMQQEAP 262
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppprpaPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  263 alPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVevtiTSEPTNETESSQAQQETPIQFPEEVEPSATQQEA 342
Cdd:PHA03247 2628 --PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA----RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADP 2701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  343 PIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQP-----PEHHEVTVSPPGHHQTHHLASPSVSVKPPDV 417
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  418 QLTIAAEPSAevgtslvhQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQetsfqSPEPINNENPSPTQQE 497
Cdd:PHA03247 2782 RLTRPAVASL--------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT-----SAQPTAPPPPPGPPPP 2848

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  498 AAAEHPQTAEEGESSlthQEAPAQTPEFPNVVVAQPPEhSHLTQATVQPLDLGFTITPESKTEvelsPTMKETPTQPPKK 577
Cdd:PHA03247 2849 SLPLGGSVAPGGDVR---RRPPSRSPAAKPAAPARPPV-RRLARPAVSRSTESFALPPDQPER----PPQPQAPPPPQPQ 2920

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  578 VVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSH 657
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  658 LTRATVQPLDLGFTITPksmtevepstalmttAPPPGHPEVTL-PPSDKGQAQHSHLTQATVQPLDLEltiTTKPTTEVK 736
Cdd:PHA03247 3001 LSRVSSWASSLALHEET---------------DPPPVSLKQTLwPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPEP 3062

                         570
                  ....*....|....*.
gi 767994885  737 PSPTTEETSTQPPDLG 752
Cdd:PHA03247 3063 HDPFAHEPDPATPEAG 3078
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-953 9.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 9.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 868 TILNFQGNYISYIDGNVWkaySWT--EKLILRENNLTELhKDSFEGLLSLQYLDLSCNKIQSIErHTFEPLPFLKFINLS 945
Cdd:COG4886  139 KELDLSNNQLTDLPEPLG---NLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLS 213


                 ....*...
gi 767994885 946 CNVITELS 953
Cdd:COG4886  214 GNQLTDLP 221
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-952 1.46e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 868 TILNFQGNYISYIDGNVWKAYSwTEKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERhTFEPLPFLKFINLSCN 947
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238


                 ....*
gi 767994885 948 VITEL 952
Cdd:COG4886  239 QLTDL 243
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 508-565 2.57e-07

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 48.90  E-value: 2.57e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767994885  508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESKTEVELSP 565
Cdd:pfam15779   1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
rne PRK10811
ribonuclease E; Reviewed
 223-593 2.96e-06

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 51.58  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  223 ETQNPETLEDIQSSSLQQEAPAQLPQ-LLEEEPSSMQQEAPALPPEssmesltlpnHEVSVQPPGEDQAYYHLPNITVKP 301
Cdd:PRK10811  655 ESQQAEVTEKARTQDEQQQAPRRERQrRRNDEKRQAQQEAKALNVE----------EQSVQETEQEERVQQVQPRRKQRQ 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPV---PPMEHELSISEQQQ-----PVQPSESPREV 373
Cdd:PRK10811  725 LNQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVvaqTAPEQDEENNAENRdnngmPRRSRRSPRHL 804

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  374 ------------ESSPTQQETP----GQPPE--------HHEVTvsPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:PRK10811  805 rvsgqrrrryrdERYPTQSPMPltvaCASPEmasgkvwiRYPVV--RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPV 882

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  430 GTSLVHQEATTrlsgsgnDVEPPAIQHGGPPLLPESSEEAGPLAVQqetsfqspEPInNENPSPTQQEAAAEHPQTAEEG 509
Cdd:PRK10811  883 VSAPVVEAVAE-------VVEEPVVVAEPQPEEVVVVETTHPEVIA--------APV-TEQPQVITESDVAVAQEVAEHA 946

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  510 ESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVT 589
Cdd:PRK10811  947 EPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPV-----VAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMT 1021


                  ....*
gi 767994885  590 N-PTP 593
Cdd:PRK10811 1022 RaPAP 1026
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-959 4.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 868 TILNFQGNYISYIDGNVwKAYSWTEKLILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIErhTFEPLPFLKFINLSCN 947
Cdd:COG4886  208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282

                         90
                 ....*....|..
gi 767994885 948 VITELSFGTFQA 959
Cdd:COG4886  283 QLTDLKLKELEL 294
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-702 7.46e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 7.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  307 TITSEPTNETES-SQAQQETPIQFPEEVEpsaTQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVE--SSPTQQETP 383
Cdd:pfam03154 147 SIPSPQDNESDSdSSAQQQILQTQPPVLQ---AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatSQPPNQTQS 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  384 GQPPeHHEVTVSPPGHHQthHLASPsvsvKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE--PPAIQHGGPP- 460
Cdd:pfam03154 224 TAAP-HTLIQQTPTLHPQ--RLPSP----HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPq 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  461 ---LLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPeFPNVVVAQPPEH- 536
Cdd:pfam03154 297 pfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP-IPQLPNPQSHKHp 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  537 SHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQlrvyqgvtnptpGQDQAQHPVSPSVTVQLLDLGLT 616
Cdd:pfam03154 376 PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ------------SQQLPPPPAQPPVLTQSQSLPPP 443

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  617 ITPEPTTEVGHSTPPKRTIvsPKHPEVTLPHPdqvqtqhshltraTVQPLDLGFTITPKSMTEVEP--STALMTTAPPPG 694
Cdd:pfam03154 444 AASHPPTSGLHQVPSQSPF--PQHPFVPGGPP-------------PITPPSGPPTSTSSAMPGIQPpsSASVSSSGPVPA 508


                  ....*...
gi 767994885  695 HPEVTLPP 702
Cdd:pfam03154 509 AVSCPLPP 516
rne PRK10811
ribonuclease E; Reviewed
 299-538 8.16e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.57  E-value: 8.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  299 VKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsiseqqqPVQPSESPREvesspt 378
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE--------PQPEEVVVVE------ 913

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  379 qqetpgqppEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTrlsgsgndveppaiqhgg 458
Cdd:PRK10811  914 ---------TTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETA------------------ 966

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  459 PPLLPESSEEAGPLAVQQETsfqSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAqtPEFpnvvVAQPPEHSH 538
Cdd:PRK10811  967 EVVVAEPEVVAQPAAPVVAE---VAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPA--PEY----VPEAPRHSD 1037
rne PRK10811
ribonuclease E; Reviewed
 215-418 1.46e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 45.80  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  215 PSQFHLEPETQNPETLEDIQSSSLQQEAPAQlpqllEEEPSSMQQEAPALPPEssmesltlPNHEVSVQPPGEDQAYYHL 294
Cdd:PRK10811  850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVE-----PVVSAPVVEAVAEVVEE--------PVVVAEPQPEEVVVVETTH 916

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  295 PNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPpmehelsisEQQQPVQPSESPREVE 374
Cdd:PRK10811  917 PEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------EPEVVAQPAAPVVAEV 987

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 767994885  375 SSPTQQETPGQPPEHHEVTVSPPGHHqtHHLASPSVSVKPPDVQ 418
Cdd:PRK10811  988 AAEVETVTAVEPEVAPAQVPEATVEH--NHATAPMTRAPAPEYV 1029
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 914-954 2.84e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767994885  914 SLQYLDLSCNKIQSIErhTFEPLPFLKFINLS-CNVITELSF 954
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSgNNKITDLSD 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 346-777 5.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  346 PPVPPMEHELSISEQQQPVQPSesPREVESSPTQQET-PGQPPEHHEVTV------SPPGHHQTHHLASPSVSVKPPDVQ 418
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPA--PRPSEPAVTSRARrPDAPPQSARPRApvddrgDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  419 LTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPP--------AIQHGGPPLLPesSEEAGPLAVQQETSFQSPEPINNE- 489
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSPPQRP--RRRAARPTVGSLTSLADPPPPPPTp 2708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  490 NPSPTQQEAAAEHPQTAeegesslthQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgftitpesktevelsPTMKE 569
Cdd:PHA03247 2709 EPAPHALVSATPLPPGP---------AAARQASPALPAAPAPPAVPAGPATPGGPAR------------------PARPP 2761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  570 TPTQPPKKVVPQLRvyqgvtnPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVghSTPPKRTIVSPKHPEVTLPHPD 649
Cdd:PHA03247 2762 TTAGPPAPAPPAAP-------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA--VLAPAAALPPAASPAGPLPPPT 2832

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  650 QVQTQHSHLTRATVQP-LDLGFTITPKS-MTEVEPSTALMTTAPPPGHPevtlPPSDKGQAQHSHLTQATVQPLDlelTI 727
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPsLPLGGSVAPGGdVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESFALPPD---QP 2905

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 767994885  728 TTKPTTEVKPSPTTEETSTQPPDLGlaiiPEPTTETRHSTALEKTTAPRP 777
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQ----PPPPPPPRPQPPLAPTTDPAG 2951
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 892-929 5.83e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 5.83e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767994885  892 EKLILRENNLTELhkDSFEGLLSLQYLDLS-CNKIQSIE 929
Cdd:pfam12799   4 EVLDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLS 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 46-535 1.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885   46 PLQLTSNPLGPPDSWSSHSSHFPREsPHAPTLPADPwdfdhLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQ 125
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARRPDAPPQ-SARPRAPVDD-----RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  126 FLASQQDLKDKLSPQERlpVSPKKlkkdPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLP--PELRVKS 203
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGR--VSRPR----RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPepAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  204 DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQlPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQ 283
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  284 P------PGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVE----------------PSATQQE 341
Cdd:PHA03247 2797 SlpspwdPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrrppsrSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  342 APIEPPV----------PPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:PHA03247 2877 APARPPVrrlarpavsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  412 VKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSgndvEPPAIQHGGPplLPESSEEAGPLAVQQETSFQSPEPINNENP 491
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA----SSTPPLTGHS--LSRVSSWASSLALHEETDPPPVSLKQTLWP 3030

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 767994885  492 SPTQQEAAAEHPQTAEEGESSLthqEAPAQTPEFPNVVVAQPPE 535
Cdd:PHA03247 3031 PDDTEDSDADSLFDSDSERSDL---EALDPLPPEPHDPFAHEPD 3071
rne PRK10811
ribonuclease E; Reviewed
 302-717 2.25e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.95  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  302 ADVEVTITSEPTNETESSQAQQETPI---QFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESS-- 376
Cdd:PRK10811  651 AETRESQQAEVTEKARTQDEQQQAPRrerQRRRNDEKRQAQQEAKALNVEEQSVQETEQEERVQQVQPRRKQRQLNQKvr 730

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  377 -PTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVqLTIAAEPSAEVGTSLVHQEATTR--------LSGSGN 447
Cdd:PRK10811  731 iEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVV-AQTAPEQDEENNAENRDNNGMPRrsrrsprhLRVSGQ 809

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  448 ------DVEPPaiqhggppllpesSEEAGPLAVqqetSFQSPE----------PInnenPSPTQQEAAAEHPQTAEEGES 511
Cdd:PRK10811  810 rrrryrDERYP-------------TQSPMPLTV----ACASPEmasgkvwiryPV----VRPQDVQVEEQREAEEVQVQP 868

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  512 SLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESKTEVELSPTMKETP-TQPPKKVVPQLRVYQGVTN 590
Cdd:PRK10811  869 VVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE-----PQPEEVVVVETTHPEVIAAPvTEQPQVITESDVAVAQEVA 943

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  591 PTPGQDQAQHPVSPSVTVQLldlglTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVqpldlgf 670
Cdd:PRK10811  944 EHAEPVVEPQDETADIEEAA-----ETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATV------- 1011

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885  671 titpksmtEVEPSTALMTTAP-------PPGHPEVTLPPSD---KGQA-QHSHLTQAT 717
Cdd:PRK10811 1012 --------EHNHATAPMTRAPapeyvpeAPRHSDWQRPTFAfegKGAAgGHSATHHAS 1061
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 894-950 2.64e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767994885 894 LILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIER--HTFEPLPFLKFINLSCNVIT 950
Cdd:cd21340  125 LNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 874-953 4.94e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340   77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142

                         90
                 ....*....|....*.
gi 767994885 938 FLKFINLSCNVITELS 953
Cdd:cd21340  143 NLEQLDASNNQISDLE 158
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 190-468 5.39e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  190 PYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEP-----ET-QNPETLEDIQ-SSSLQQEAPAQLPQLLEEEPSSMQQEAP 262
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvrtgyEKyKEPEPIPDLQvDASLWGVAPKKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  263 ALPPESSMeSLtlpnHEVsvqppgEDQAYYHLPNITVKPADVEVTITSEPTnetessQAQQETPIQFPEEVEPSATQQEA 342
Cdd:pfam09770 187 PAPSRKMM-SL----EEV------EAAMRAQAKKPAQQPAPAPAQPPAAPP------AQQAQQQQQFPPQIQQQQQPQQQ 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885  343 PIEPPvPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPehhevtvsPPGHHQTHHLASPSVsvkPPDVQLTIA 422
Cdd:pfam09770 250 PQQPQ-QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPP--------PVPVQPTQILQNPNR---LSAARVGYP 317

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 767994885  423 AEPSAEVGTSLVHQEATTRLSGSGNdvePPAIQHggPPLLPESSEE 468
Cdd:pfam09770 318 QNPQPGVQPAPAHQAHRQQGSFGRQ---APIITH--PQQLAQLSEE 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
900-952 5.95e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 5.95e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767994885 900 NLTEL---HKDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLSCNVITEL 952
Cdd:COG4886   97 NLTELdlsGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL 151
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 154-602 7.29e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.09  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 154 PAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPElrvksdEPPGPSEQVGPSQFHLEPETQNP-ETLED 232
Cdd:PRK14949 362 PVKRWQVDDPAEISLPEGQTPSALAAAVQAPHANEPQFVNAAPAE------KKTALTEQTTAQQQVQAANAEAVaEADAS 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 233 IQSSSLQQEAPAQLPQLLEEEPSSMQ---QEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHlPNITVKPADVEVTIT 309
Cdd:PRK14949 436 AEPADTVEQALDDESELLAALNAEQAvilSQAQSQGFEASSSLDADNSAVPEQIDSTAEQSVVN-PSVTDTQVDDTSASN 514

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 310 SEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsISEQQQPVQPSESPREVESSPTQQETPGQPPEH 389
Cdd:PRK14949 515 NSAADNTVDDNYSAEDTLESNGLDEGDYAQDSAPLDAYQDDYVAF--SSESYNALSDDEQHSANVQSAQSAAEAQPSSQS 592

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 390 HEVTVSPPghhqthhlaSPSVSVKPPDV-QLTIAAEPS--AEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESS 466
Cdd:PRK14949 593 LSPISAVT---------TAAASLADDDIlDAVLAARDSllSDLDALSPKEGDGKKSSADRKPKTPPSRAPPASLSKPASS 663

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 467 EEAGPLAVQQETSFQS-PEPINNENPSPTQ-QEAAAEHPQT----------AEEGESSLTHQEAPAQTPEFPNVV----- 529
Cdd:PRK14949 664 PDASQTSASFDLDPDFeLATHQSVPEAALAsGSAPAPPPVPdpydrppweeAPEVASANDGPNNAAEGNLSESVEdasns 743

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767994885 530 ----VAQPPEHSHLTQATVQPldlgftitpesktevelsPTMKETPTQPPKKVVPQlrvyQGVTNPTPGQDQAQHPV 602
Cdd:PRK14949 744 elqaVEQQATHQPQVQAEAQS------------------PASTTALTQTSSEVQDT----ELNLVLLSSGSITGHPL 798
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
306-383 8.25e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 39.23  E-value: 8.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 306 VTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIE-PPVPPMEhelsiSEQQQP--VQPSESPREVESSPTQQET 382
Cdd:PRK13042  21 ITTTTQAANATTPSSTKVEAPQSTPPSTKVEAPQSKPNATtPPSTKVE-----APQQTPnaTTPSSTKVETPQSPTTKQV 95


                 .
gi 767994885 383 P 383
Cdd:PRK13042  96 P 96
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
301-510 8.86e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 40.03  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 301 PADVEVTITSEPTNETE---SSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPvQPSESPrEVESSP 377
Cdd:PRK14960 363 PNEILVSEPVQQNGQAEvglNSQAQTAQEITPVSAVQPVEVISQPAMVEPEPEPEPEPEPEPEPEP-EPEPEP-EPEPEP 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767994885 378 tqqetpgQPPEHHEVTVSPPGHHQTHHLASPSVSvkppdVQLTIAAEPSAEVGTS-LVHQEATTRLsgsgNDVEPPAIQH 456
Cdd:PRK14960 441 -------EPQPNQDLMVFDPNHHELIGLESAVVQ-----ETVSVLEEDFIPVPEQkLVQVQAETQV----KQIEPEPAST 504

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767994885 457 GGPPLLPESSEEAGPLAVQQETSFQSPEPINNENP----SPTQQEAAAEHPQTAEEGE 510
Cdd:PRK14960 505 AEPIGLFEASSAEFSLAQDTSAYDLVSEPVIEQQSlvqaEIVETVAVVKEPNATDNSQ 562
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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