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NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 [ Homo sapiens (human) ]

Gene ID: 4731, updated on 5-Aug-2018
Official Symbol
NDUFV3provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit V3provided by HGNC
Primary source
HGNC:HGNC:7719
See related
Ensembl:ENSG00000160194 MIM:602184; Vega:OTTHUMG00000086823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CI-10k; CI-9KD
Summary
The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 8.3), heart (RPKM 7.9) and 25 other tissues See more
Orthologs
See NDUFV3 in Genome Data Viewer
Location:
21q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (42893268..42911396)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44313378..44329773)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985479 Neighboring gene WD repeat domain 4 Neighboring gene uncharacterized LOC105372817 Neighboring gene endogenous retrovirus group 48 member 1 Neighboring gene microRNA 5692b

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates NDUFV3 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial respiratory chain complex I NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Names
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
NADH-ubiquinone oxidoreductase 9 kD subunit
NADH-ubiquinone oxidoreductase 9 kDa subunit
NADH-ubiquinone oxidoreductase flavoprotein 3, 10kD
complex I 10kDa subunit
complex I, mitochondrial respiratory chain, 10-kD subunit
complex I-9kD
mitochondrial NADH oxidoreductase-like protein
renal carcinoma antigen NY-REN-4
NP_001001503.1
NP_066553.3
XP_011527888.1
XP_016883848.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042281.1 RefSeqGene

    Range
    5001..21396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001503.1NP_001001503.1  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001001503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC033766, BI829092, CF123536
    Consensus CDS
    CCDS33573.1
    UniProtKB/Swiss-Prot
    P56181
    Related
    ENSP00000342895.3, OTTHUMP00000109387, ENST00000340344.4, OTTHUMT00000195448
    Conserved Domains (1) summary
    pfam15880
    Location:67100
    NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
  2. NM_021075.3NP_066553.3  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_066553.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC021217, BC033766, BF311986, BI829092, BU629860, CF123536
    Consensus CDS
    CCDS33572.1
    UniProtKB/Swiss-Prot
    P56181
    Related
    ENSP00000346196.2, OTTHUMP00000109386, ENST00000354250.6, OTTHUMT00000195447
    Conserved Domains (1) summary
    pfam15880
    Location:432465
    NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    42893268..42911396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529586.2XP_011527888.1  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam15880
    Location:453486
    NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
  2. XM_017028359.1XP_016883848.1  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2

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