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NCL nucleolin [ Homo sapiens (human) ]

Gene ID: 4691, updated on 18-Dec-2016
Official Symbol
NCLprovided by HGNC
Official Full Name
nucleolinprovided by HGNC
Primary source
HGNC:HGNC:7667
See related
Ensembl:ENSG00000115053 MIM:164035; Vega:OTTHUMG00000153866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C23
Summary
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q37.1
Exon count:
14
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (231454748..231464494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232319459..232329208, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 8 opposite strand pseudogene 2 Neighboring gene HIG1 hypoxia inducible domain family member 2A pseudogene Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene small nucleolar RNA, C/D box 20 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene uncharacterized LOC107985998 Neighboring gene RNA, U2 small nuclear 22, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of nucleolin and modulates the expression of LC3, leading to autophage and cell death of uninfected CD4 T cells PubMed
env Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag The presence of HIV-1 Gag protein upregulates the levels of cytoplasmic nucleolin in Gag expression 293T cells PubMed
gag Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Nucleolin binds HIV-1 Gag and enhances the release of HIV-1 virions containing viral genomic RNA with the RNA packaging signal, psi PubMed
gag Nucleolin is incorporated into HIV-1 particles during budding of HIV-1 from lipid rafts and following virus entry into cells is recovered in fractions containing HIV-1 DNA, the Matrix protein of HIV-1 Gag and HIV-1 Reverse Transcriptase PubMed
Tat tat Nucleolin is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
matrix gag Nucleolin is incorporated into HIV-1 particles during budding of HIV-1 from lipid rafts and following virus entry into cells is recovered in fractions containing HIV-1 DNA, Matrix and Reverse Transcriptase proteins PubMed
nucleocapsid gag Nucleolin is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
reverse transcriptase gag-pol After HIV entry into cells, equilibrium density fractionation of cellular extracts revealed cell surface nucleolin is recovered in fractions containing actin, HIV DNA, viral matrix, and reverse transcriptase, suggesting nucleolin accompanies viral entry PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ45706, FLJ59041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005381.2NP_005372.2  nucleolin

    See identical proteins and their annotated locations for NP_005372.2

    Status: REVIEWED

    Source sequence(s)
    AK000221, AK001314, BM761058, BQ001029
    Consensus CDS
    CCDS33397.1
    UniProtKB/Swiss-Prot
    P19338
    UniProtKB/TrEMBL
    A0A024R4A0, B3KM80
    Related
    ENSP00000318195, OTTHUMP00000204507, ENST00000322723, OTTHUMT00000332731
    Conserved Domains (5) summary
    COG0724
    Location:379628
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12403
    Location:307381
    RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
    cd12404
    Location:390465
    RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
    cd12405
    Location:485557
    RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
    cd12406
    Location:572649
    RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

    Range
    231454748..231464494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    232325275..232335021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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