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NCAM2 neural cell adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 4685, updated on 6-Sep-2021

Summary

Official Symbol
NCAM2provided by HGNC
Official Full Name
neural cell adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:7657
See related
Ensembl:ENSG00000154654 MIM:602040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCAM21
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues See more
Orthologs
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Genomic context

See NCAM2 in Genome Data Viewer
Location:
21q21.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (20998339..21543329)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (22370727..22915650)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 320 Neighboring gene peptidylprolyl isomerase A pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 317 Neighboring gene long intergenic non-protein coding RNA 1425

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study on obesity and obesity-related traits.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
GeneReviews: Not available
Joint influence of small-effect genetic variants on human longevity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
neural cell adhesion molecule 2
Names
N-CAM-2
NCAM-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352591.2NP_001339520.1  neural cell adhesion molecule 2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001115, AP001137, AP001138, AP001252
    Conserved Domains (6) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain
  2. NM_001352592.2NP_001339521.1  neural cell adhesion molecule 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP001115, AP001136, AP001137, AP001138, AP001252
    Conserved Domains (6) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    pfam13927
    Location:426504
    Ig_3; Immunoglobulin domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  3. NM_001352593.2NP_001339522.1  neural cell adhesion molecule 2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001137, AP001138, AP001252
    Conserved Domains (6) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain
  4. NM_001352594.2NP_001339523.1  neural cell adhesion molecule 2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AP001137, AP001138, AP001252
    Conserved Domains (6) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain
  5. NM_001352595.2NP_001339524.1  neural cell adhesion molecule 2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AK299054, AP001115, AP001137
    Conserved Domains (5) summary
    cd05870
    Location:158255
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:354446
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:452536
    fn3; Fibronectin type III domain
    pfam13927
    Location:259337
    Ig_3; Immunoglobulin domain
    cl11960
    Location:66159
    Ig; Immunoglobulin domain
  6. NM_001352596.2NP_001339525.1  neural cell adhesion molecule 2 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AI500562, AP001137, AP001138, AP001252
    Conserved Domains (5) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496556
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam13927
    Location:401479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain
  7. NM_001352597.2NP_001339526.1  neural cell adhesion molecule 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AK302870
    Conserved Domains (4) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    pfam13927
    Location:147212
    Ig_3; Immunoglobulin domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  8. NM_004540.5NP_004531.2  neural cell adhesion molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_004531.2

    Status: REVIEWED

    Source sequence(s)
    AI207079, AP001115, BC052946
    Consensus CDS
    CCDS42910.1
    UniProtKB/Swiss-Prot
    O15394
    Related
    ENSP00000383392.1, ENST00000400546.6
    Conserved Domains (8) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:414482
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:308395
    IG_like; Immunoglobulin like
    cd00063
    Location:496588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:22111
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:594678
    fn3; Fibronectin type III domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    20998339..21543329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452081.1XP_024307849.1  neural cell adhesion molecule 2 isoform X5

    Conserved Domains (6) summary
    cd05866
    Location:21112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:300397
    Ig_NCAM-2; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    cd00063
    Location:496588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594678
    fn3; Fibronectin type III domain
    pfam13927
    Location:401479
    Ig_3; Immunoglobulin domain
    cl11960
    Location:208301
    Ig; Immunoglobulin domain
  2. XM_011529576.3XP_011527878.1  neural cell adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011527878.1

    Conserved Domains (8) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333420
    IG_like; Immunoglobulin like
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  3. XM_017028356.2XP_016883845.1  neural cell adhesion molecule 2 isoform X6

    Conserved Domains (7) summary
    cd05870
    Location:136233
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:250318
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144231
    IG_like; Immunoglobulin like
    cd00063
    Location:332424
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:51134
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430514
    fn3; Fibronectin type III domain
    cl11960
    Location:44137
    Ig; Immunoglobulin domain
  4. XM_017028357.2XP_016883846.1  neural cell adhesion molecule 2 isoform X7

  5. XM_011529575.3XP_011527877.1  neural cell adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011527877.1

    Conserved Domains (8) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333420
    IG_like; Immunoglobulin like
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  6. XM_011529581.3XP_011527883.1  neural cell adhesion molecule 2 isoform X3

    Conserved Domains (8) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333420
    IG_like; Immunoglobulin like
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  7. XM_011529580.3XP_011527882.1  neural cell adhesion molecule 2 isoform X2

    Conserved Domains (8) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333420
    IG_like; Immunoglobulin like
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  8. XM_011529582.3XP_011527884.1  neural cell adhesion molecule 2 isoform X4

    Conserved Domains (8) summary
    cd05866
    Location:46137
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    cd05870
    Location:325422
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:439507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:333420
    IG_like; Immunoglobulin like
    cd00063
    Location:521613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:47136
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:619703
    fn3; Fibronectin type III domain
    cl11960
    Location:233326
    Ig; Immunoglobulin domain
  9. XM_011529585.3XP_011527887.1  neural cell adhesion molecule 2 isoform X6

    See identical proteins and their annotated locations for XP_011527887.1

    Conserved Domains (7) summary
    cd05870
    Location:136233
    Ig5_NCAM-2; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-2 (also known as OCAM/mamFas II and RNCAM)
    smart00408
    Location:250318
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144231
    IG_like; Immunoglobulin like
    cd00063
    Location:332424
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:51134
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430514
    fn3; Fibronectin type III domain
    cl11960
    Location:44137
    Ig; Immunoglobulin domain
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