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NAP1L1 nucleosome assembly protein 1 like 1 [ Homo sapiens (human) ]

Gene ID: 4673, updated on 11-Sep-2019

Summary

Official Symbol
NAP1L1provided by HGNC
Official Full Name
nucleosome assembly protein 1 like 1provided by HGNC
Primary source
HGNC:HGNC:7637
See related
Ensembl:ENSG00000187109 MIM:164060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRP; NAP1; NAP1L
Summary
This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 100.8), lymph node (RPKM 74.3) and 25 other tissues See more
Orthologs

Genomic context

See NAP1L1 in Genome Data Viewer
Location:
12q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (76036585..76084687, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (76438672..76478738, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369847 Neighboring gene pleckstrin homology like domain family A member 1 Neighboring gene density regulated re-initiation and release factor pseudogene Neighboring gene RNA, U6 small nuclear 1271, pseudogene Neighboring gene reticulon 4 interacting protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, nucleosome assembly protein 1-like 1 (NAP1L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NAP1L1 is decreased by RRE PubMed
rev HIV-1 Rev interacts with nucleosome assembly protein 1 (Nap1) in cells and this interaction involves amino acid residues 41-51 in Rev. Nap1 modulates the nuclear import of Rev PubMed
Tat tat NAP1 co-localizes with HIV-1 Tat at the nuclear rim and is required for the transport of Tat within the nucleus rather than for the remodeling of nucleosomes on the provirus PubMed
tat HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription PubMed
tat NAP-1 interacts with HIV-1 Tat, leading to cooperative activation of HIV-1 gene expression. Residues 162-391 of NAP-1 and residues 49-57 of Tat are involved in the interaction PubMed
tat NAP1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
nucleocapsid gag Nucleosome assembly protein 1-like 1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8688, FLJ16112, MGC23410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nucleosome assembly protein 1-like 1
Names
HSP22-like protein interacting protein
NAP-1-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307924.3NP_001294853.1  nucleosome assembly protein 1-like 1 isoform 2

    See identical proteins and their annotated locations for NP_001294853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011611, AK295147, AL162068, BF666587, BM929581, BU183927, DA512918, HY300507
    Consensus CDS
    CCDS76581.1
    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    B7Z2V4, F5H4R6
    Related
    ENSP00000445008.2, ENST00000535020.6
    Conserved Domains (1) summary
    pfam00956
    Location:76344
    NAP; Nucleosome assembly protein (NAP)
  2. NM_001330231.2NP_001317160.1  nucleosome assembly protein 1-like 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, CX870413, DA137494, DA512918, DB546929, M86667
    Consensus CDS
    CCDS9013.1
    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    A0A024RBB7, Q9H2B0
    Conserved Domains (1) summary
    pfam00956
    Location:76343
    NAP; Nucleosome assembly protein (NAP)
  3. NM_001330232.2NP_001317161.1  nucleosome assembly protein 1-like 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the 5' coding region and differs in the 3' UTR compared to variant 2. The encoded isoform (3) is shorter, but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AA057019, AC011611, AF300335, AL162068, AW950481, CD000987, CD678271, DA137494, DA344092, DA512918, DB546929, M86667
    Consensus CDS
    CCDS81715.1
    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    F8W543, Q9H2B0
    Conserved Domains (1) summary
    pfam00956
    Location:15280
    NAP; Nucleosome assembly protein (NAP)
  4. NM_004537.7NP_004528.1  nucleosome assembly protein 1-like 1 isoform 1

    See identical proteins and their annotated locations for NP_004528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929
    Consensus CDS
    CCDS9013.1
    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    A0A024RBB7, Q9H2B0
    Related
    ENSP00000477538.1, ENST00000618691.5
    Conserved Domains (1) summary
    pfam00956
    Location:76343
    NAP; Nucleosome assembly protein (NAP)
  5. NM_139207.5NP_631946.1  nucleosome assembly protein 1-like 1 isoform 1

    See identical proteins and their annotated locations for NP_631946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929, M86667
    Consensus CDS
    CCDS9013.1
    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    A0A024RBB7, Q9H2B0
    Related
    ENSP00000261182.8, ENST00000261182.12
    Conserved Domains (1) summary
    pfam00956
    Location:76343
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    76036585..76084687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019340.2XP_016874829.1  nucleosome assembly protein 1-like 1 isoform X2

    UniProtKB/TrEMBL
    F8W543
    Conserved Domains (1) summary
    pfam00956
    Location:15280
    NAP; Nucleosome assembly protein (NAP)
  2. XM_017019338.1XP_016874827.1  nucleosome assembly protein 1-like 1 isoform X1

    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    A0A024RBB7
    Related
    ENSP00000450236.1, ENST00000552056.5
    Conserved Domains (1) summary
    pfam00956
    Location:76343
    NAP; Nucleosome assembly protein (NAP)
  3. XM_024448983.1XP_024304751.1  nucleosome assembly protein 1-like 1 isoform X2

    Related
    ENSP00000448167.1, ENST00000547773.5
    Conserved Domains (1) summary
    pfam00956
    Location:15280
    NAP; Nucleosome assembly protein (NAP)
  4. XM_017019339.1XP_016874828.1  nucleosome assembly protein 1-like 1 isoform X2

    UniProtKB/TrEMBL
    F8W543
    Conserved Domains (1) summary
    pfam00956
    Location:15280
    NAP; Nucleosome assembly protein (NAP)
  5. XM_011538393.2XP_011536695.1  nucleosome assembly protein 1-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011536695.1

    UniProtKB/Swiss-Prot
    P55209
    UniProtKB/TrEMBL
    A0A024RBB7
    Conserved Domains (1) summary
    pfam00956
    Location:76343
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_001748717.2 RNA Sequence

  2. XR_001748715.2 RNA Sequence

  3. XR_001748714.2 RNA Sequence

  4. XR_001748716.1 RNA Sequence

  5. XR_002957328.1 RNA Sequence

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