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Nap1l1 nucleosome assembly protein 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 53605, updated on 2-Nov-2024

Summary

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Official Symbol
Nap1l1provided by MGI
Official Full Name
nucleosome assembly protein 1-like 1provided by MGI
Primary source
MGI:MGI:1855693
See related
Ensembl:ENSMUSG00000058799 AllianceGenome:MGI:1855693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAP-1; D10Ertd68e
Summary
Predicted to enable several functions, including chromatin binding activity; histone binding activity; and histone chaperone activity. Involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including blood; forebrain; genitourinary system; liver; and nucleus pulposus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 94.0), CNS E14 (RPKM 38.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Nap1l1 in Genome Data Viewer
Location:
10 D1; 10 58.67 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111308754..111334011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111472882..111498150)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40761 Neighboring gene STARR-seq mESC enhancer starr_27865 Neighboring gene STARR-seq mESC enhancer starr_27868 Neighboring gene STARR-seq mESC enhancer starr_27869 Neighboring gene predicted gene, 30145 Neighboring gene STARR-seq mESC enhancer starr_27871 Neighboring gene STARR-seq mESC enhancer starr_27875 Neighboring gene STARR-positive B cell enhancer ABC_E5181 Neighboring gene STARR-positive B cell enhancer ABC_E6921 Neighboring gene STARR-positive B cell enhancer ABC_E10641 Neighboring gene predicted gene, 25117 Neighboring gene STARR-positive B cell enhancer ABC_E6922 Neighboring gene high mobility group box 2 pseudogene Neighboring gene pleckstrin homology like domain, family A, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5. Liang X, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Sep 25. PMID 36148951, Free PMC Article
  2. Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes. Li L, et al. J Cell Biochem, 2012 Dec. PMID 22807403
  3. Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells. Yan Y, et al. Cell Physiol Biochem, 2016. PMID 26824453
  4. Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells. Gong H, et al. Stem Cells, 2014 Jul. PMID 24648372
  5. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation. Dominguez F, et al. J Virol, 2021 Jul 26. PMID 34076483, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
    Title: NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
  2. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
    Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
  3. These findings reveal an essential role for the Nap1l1 histone chaperone in cortical neurogenesis during early embryonic brain development.
    Title: Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.
  4. Nap1l1 promotes the proliferation of iPSC attributable to G2/M transition caused by downregulation of p27 and p21, and upregulation of cyclin B1, the activation of AKT or ERK is involved in the process.
    Title: Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells.
  5. The molecular interaction between DGKzeta and Nap1l1 was attenuated after hypoxic stress.
    Title: Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.
  6. Downregulation of Nap1l1 significantly enhances mesodermal induction and subsequent cardiogenesis of murine induced pluripotent stem cells via inhibition of gamma-secretase-regulated Notch signaling.
    Title: Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells.
  7. Nap1l1 is a novel protein that regulates cardiomyocytes differentiation of P19CL6 cells induced by dimethyl sulfoxide.
    Title: Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes.
  8. Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
    Title: Interaction between nucleosome assembly protein 1-like family members.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleosome assembly protein 1-like 1
Names
NAP-1-related protein
brain protein DN38
nucleosome assembly protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358932.1 → NP_001345861.1  nucleosome assembly protein 1-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK011301, AK012250, AW488539, BF458793, BM948894, BY253657
    UniProtKB/TrEMBL
    Q9CSP8
    Conserved Domains (1) summary
    pfam00956
    Location:15 → 280
    NAP; Nucleosome assembly protein (NAP)

  2. NM_001428957.1 → NP_001415886.1  nucleosome assembly protein 1-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166253

  3. NM_001428958.1 → NP_001415887.1  nucleosome assembly protein 1-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166253

  4. NM_001428959.1 → NP_001415888.1  nucleosome assembly protein 1-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166253

  5. NM_001428960.1 → NP_001415889.1  nucleosome assembly protein 1-like 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC166253

  6. NM_001428961.1 → NP_001415890.1  nucleosome assembly protein 1-like 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC166253

  7. NM_015781.5 → NP_056596.1  nucleosome assembly protein 1-like 1 isoform 2

    See identical proteins and their annotated locations for NP_056596.1

    Status: VALIDATED

    Source sequence(s)
    AK011301, AK136161, BF458793
    Consensus CDS
    CCDS36058.1
    UniProtKB/Swiss-Prot
    P28656, Q3UL14
    UniProtKB/TrEMBL
    Q3TF41
    Related
    ENSMUSP00000070068.9, ENSMUST00000065917.16
    Conserved Domains (1) summary
    pfam00956
    Location:78 → 343
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    111308754..111334011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245178.2 → XP_030101038.1  nucleosome assembly protein 1-like 1 isoform X1

    UniProtKB/Swiss-Prot
    P28656, Q3UL14
    UniProtKB/TrEMBL
    Q3TF41
    Related
    ENSMUSP00000151750.2, ENSMUST00000217908.2
    Conserved Domains (1) summary
    pfam00956
    Location:78 → 343
    NAP; Nucleosome assembly protein (NAP)

  2. XM_030245179.1 → XP_030101039.1  nucleosome assembly protein 1-like 1 isoform X3

    UniProtKB/TrEMBL
    Q9CSP8
    Conserved Domains (1) summary
    pfam00956
    Location:15 → 280
    NAP; Nucleosome assembly protein (NAP)

  3. XM_036155892.1 → XP_036011785.1  nucleosome assembly protein 1-like 1 isoform X2

    UniProtKB/TrEMBL
    Q9CSP8
    Conserved Domains (1) summary
    pfam00956
    Location:35 → 302
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_001779558.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146707.1: Suppressed sequence

    Description
    NM_001146707.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NR_152558.1: Suppressed sequence

    Description
    NR_152558.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28656.2 GenPept UniProtKB/Swiss-Prot:P28656

Gene LinkOut

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