Format

Send to:

Choose Destination

MYT1 myelin transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 4661, updated on 13-Mar-2020

Summary

Official Symbol
MYT1provided by HGNC
Official Full Name
myelin transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:7622
See related
Ensembl:ENSG00000196132 MIM:600379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTF1; MYTI; NZF2; PLPB1; ZC2H2C1; ZC2HC4A; C20orf36
Summary
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.2), adrenal (RPKM 2.1) and 3 other tissues See more
Orthologs

Genomic context

See MYT1 in Genome Data Viewer
Location:
20q13.33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (64164452..64242253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62795827..62873606)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene B6.7 minisatellite repeat instability region Neighboring gene uncharacterized LOC105372727 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene long intergenic non-protein coding RNA 266-1 Neighboring gene capicua transcriptional repressor pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PCMTD2

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myelin transcription factor 1
Names
myelin transcription factor I
neural zinc finger transcription factor 2
proteolipid protein binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004535.3NP_004526.1  myelin transcription factor 1

    See identical proteins and their annotated locations for NP_004526.1

    Status: REVIEWED

    Source sequence(s)
    AB020642, AL121581, BC053638
    Consensus CDS
    CCDS13558.1
    UniProtKB/Swiss-Prot
    Q01538
    Related
    ENSP00000327465.1, ENST00000328439.6
    Conserved Domains (3) summary
    pfam01530
    Location:843869
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:560791
    MYT1; Myelin transcription factor 1
    pfam14357
    Location:10011074
    DUF4404; Domain of unknown function (DUF4404)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    64164452..64242253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    73043..150844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center