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MYT1 myelin transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 4661, updated on 2-Oct-2018

Summary

Official Symbol
MYT1provided by HGNC
Official Full Name
myelin transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:7622
See related
Ensembl:ENSG00000196132 MIM:600379; Vega:OTTHUMG00000149988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTF1; MYTI; NZF2; PLPB1; ZC2H2C1; ZC2HC4A; C20orf36
Summary
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.2), adrenal (RPKM 2.1) and 3 other tissues See more
Orthologs

Genomic context

See MYT1 in Genome Data Viewer
Location:
20q13.33
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (64164474..64242253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62795827..62873606)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene B6.7 minisatellite repeat instability region Neighboring gene uncharacterized LOC105372727 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene long intergenic non-protein coding RNA 266-1 Neighboring gene capicua transcriptional repressor pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
    G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
    MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PCMTD2

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myelin transcription factor 1
Names
myelin transcription factor I
neural zinc finger transcription factor 2
proteolipid protein binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004535.2NP_004526.1  myelin transcription factor 1

    See identical proteins and their annotated locations for NP_004526.1

    Status: REVIEWED

    Source sequence(s)
    AB020642, BC053638
    Consensus CDS
    CCDS13558.1
    UniProtKB/Swiss-Prot
    Q01538
    Related
    ENSP00000327465.1, OTTHUMP00000031644, ENST00000328439.5, OTTHUMT00000080297
    Conserved Domains (3) summary
    pfam01530
    Location:843869
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:560791
    MYT1; Myelin transcription factor 1
    pfam14357
    Location:10011074
    DUF4404; Domain of unknown function (DUF4404)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    64164474..64242253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    73065..150844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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