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MYT1 myelin transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 4661, updated on 9-Jun-2025
Official Symbol
MYT1provided by HGNC
Official Full Name
myelin transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:7622
See related
Ensembl:ENSG00000196132 MIM:600379; AllianceGenome:HGNC:7622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTF1; MYTI; NZF2; PLPB1; ZC2H2C1; ZC2HC4A; C20orf36
Summary
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.2), adrenal (RPKM 2.1) and 3 other tissues See more
Orthologs
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See MYT1 in Genome Data Viewer
Location:
20q13.33
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64164452..64242253)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65983955..66063029)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62795805..62873606)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62740950-62741133 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62751601-62752100 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62754467-62755666 Neighboring gene B6.7 minisatellite repeat instability region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62768655-62769156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62769157-62769656 Neighboring gene uncharacterized LOC105372727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62771493-62772406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62782269-62782948 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:62782949-62784148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62790052-62790772 Neighboring gene VISTA enhancer hs2609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62809687-62810387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62819145-62820082 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62820083-62821020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62842693-62843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62854891-62855746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62857693-62858192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62875914-62876414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62901205-62901706 Neighboring gene uncharacterized LOC124904957 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene IL9R pseudogene 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: PCMTD2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
myelin transcription factor 1
Names
myelin transcription factor I
neural zinc finger transcription factor 2
proteolipid protein binding protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004535.3NP_004526.1  myelin transcription factor 1

    See identical proteins and their annotated locations for NP_004526.1

    Status: REVIEWED

    Source sequence(s)
    AB020642, AL121581, BC053638
    Consensus CDS
    CCDS13558.1
    UniProtKB/Swiss-Prot
    E1P5H0, F5H7M8, O94922, Q01538, Q7Z5W2, Q9UPV2
    Related
    ENSP00000327465.1, ENST00000328439.6
    Conserved Domains (3) summary
    pfam01530
    Location:843869
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:560791
    MYT1; Myelin transcription factor 1
    pfam14357
    Location:10011074
    DUF4404; Domain of unknown function (DUF4404)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    64164452..64242253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    73043..150844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65983955..66063029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)