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PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 55251, updated on 1-Aug-2020

Summary

Official Symbol
PCMTD2provided by HGNC
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:15882
See related
Ensembl:ENSG00000203880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf36
Expression
Ubiquitous expression in ovary (RPKM 29.8), skin (RPKM 21.9) and 25 other tissues See more
Orthologs

Genomic context

See PCMTD2 in Genome Data Viewer
Location:
20q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (64255695..64276226)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62887048..62907583)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372727 Neighboring gene myelin transcription factor 1 Neighboring gene long intergenic non-protein coding RNA 266-1 Neighboring gene septin 14 pseudogene 20 Neighboring gene capicua transcriptional repressor pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MYT1

Homology

Clone Names

  • FLJ10883, KIAA0835, KIAA1050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein-L-isoaspartate O-methyltransferase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104925.1NP_001098395.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001098395.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC033665, BC040945, CA443672, DB224815
    Consensus CDS
    CCDS46631.1
    UniProtKB/Swiss-Prot
    Q9NV79
    Related
    ENSP00000358773.3, ENST00000369758.8
    Conserved Domains (1) summary
    cl28095
    Location:11193
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  2. NM_018257.3NP_060727.2  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060727.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK001745, BC033665, CA443672, DB224815
    Consensus CDS
    CCDS13559.1
    UniProtKB/Swiss-Prot
    Q9NV79
    Related
    ENSP00000307854.6, ENST00000308824.11
    Conserved Domains (1) summary
    cl28095
    Location:11219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    64255695..64276226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187624.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    164286..183433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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