U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myt1 myelin transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 17932, updated on 21-Apr-2024

Summary

Official Symbol
Myt1provided by MGI
Official Full Name
myelin transcription factor 1provided by MGI
Primary source
MGI:MGI:1100535
See related
Ensembl:ENSMUSG00000010505 AllianceGenome:MGI:1100535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nzf2; Nzf2a; Nzf2b; Nztf2
Summary
This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression
Biased expression in CNS E14 (RPKM 7.7), whole brain E14.5 (RPKM 7.3) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2 H4; 2 103.77 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181405099..181469579)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181763332..181827775)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid receptor-like 1 Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0835

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within diaphragm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myelin transcription factor 1
Names
NZF-2
neural zinc finger factor 2
neural zinc finger transcription factor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171615.2NP_001165086.1  myelin transcription factor 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 3) that maintains the reading frame but is longer at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS50856.1
    UniProtKB/TrEMBL
    B0R0C1
    Related
    ENSMUSP00000079900.5, ENSMUST00000081125.11
    Conserved Domains (3) summary
    pfam01530
    Location:887913
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:604835
    MYT1; Myelin transcription factor 1
    pfam14357
    Location:10451118
    DUF4404; Domain of unknown function (DUF4404)
  2. NM_001171616.2NP_001165087.1  myelin transcription factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001165087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS50857.1
    UniProtKB/Swiss-Prot
    Q8CFC2
    Related
    ENSMUSP00000104388.3, ENSMUST00000108757.9
    Conserved Domains (3) summary
    TIGR04523
    Location:9571029
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:807835
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:524755
    MYT1; Myelin transcription factor 1
  3. NM_001420423.1NP_001407352.1  myelin transcription factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL845173
  4. NM_001420424.1NP_001407353.1  myelin transcription factor 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL845173
  5. NM_008665.5NP_032691.2  myelin transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_032691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL845173
    Consensus CDS
    CCDS17223.1
    UniProtKB/Swiss-Prot
    B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
    Related
    ENSMUSP00000104387.2, ENSMUST00000108756.8
    Conserved Domains (3) summary
    TIGR04523
    Location:9951067
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:845873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562793
    MYT1; Myelin transcription factor 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181405099..181469579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159141.1XP_036015034.1  myelin transcription factor 1 isoform X6

    Conserved Domains (3) summary
    TIGR04523
    Location:9991071
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:849877
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:566797
    MYT1; Myelin transcription factor 1
  2. XM_036159150.1XP_036015043.1  myelin transcription factor 1 isoform X8

    Conserved Domains (3) summary
    TIGR04523
    Location:9781050
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:828856
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:545776
    MYT1; Myelin transcription factor 1
  3. XM_036159159.1XP_036015052.1  myelin transcription factor 1 isoform X10

    Conserved Domains (3) summary
    TIGR04523
    Location:907979
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:757785
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474705
    MYT1; Myelin transcription factor 1
  4. XM_036159155.1XP_036015048.1  myelin transcription factor 1 isoform X9

    Conserved Domains (3) summary
    TIGR04523
    Location:9741046
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:824852
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:541772
    MYT1; Myelin transcription factor 1
  5. XM_006500581.5XP_006500644.2  myelin transcription factor 1 isoform X12

    Conserved Domains (2) summary
    pfam01530
    Location:845873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562793
    MYT1; Myelin transcription factor 1
  6. XM_036159123.1XP_036015016.1  myelin transcription factor 1 isoform X3

    Conserved Domains (3) summary
    TIGR04523
    Location:9721044
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:822850
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562793
    MYT1; Myelin transcription factor 1
  7. XM_036159133.1XP_036015026.1  myelin transcription factor 1 isoform X5

    Conserved Domains (3) summary
    TIGR04523
    Location:9511023
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:801829
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562793
    MYT1; Myelin transcription factor 1
  8. XM_006500577.5XP_006500640.2  myelin transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006500640.2

    UniProtKB/Swiss-Prot
    B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
    Conserved Domains (3) summary
    TIGR04523
    Location:9951067
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:845873
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:562793
    MYT1; Myelin transcription factor 1
  9. XM_006500579.5XP_006500642.2  myelin transcription factor 1 isoform X4

    See identical proteins and their annotated locations for XP_006500642.2

    UniProtKB/Swiss-Prot
    Q8CFC2
    Conserved Domains (3) summary
    TIGR04523
    Location:9571029
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:807835
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:524755
    MYT1; Myelin transcription factor 1
  10. XM_006500578.5XP_006500641.1  myelin transcription factor 1 isoform X2

    Conserved Domains (3) summary
    TIGR04523
    Location:10541126
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:904932
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:621852
    MYT1; Myelin transcription factor 1
  11. XM_036159160.1XP_036015053.1  myelin transcription factor 1 isoform X10

    Conserved Domains (3) summary
    TIGR04523
    Location:907979
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:757785
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474705
    MYT1; Myelin transcription factor 1
  12. XM_036159162.1XP_036015055.1  myelin transcription factor 1 isoform X11

    Conserved Domains (3) summary
    TIGR04523
    Location:884956
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01530
    Location:734762
    zf-C2HC; Zinc finger, C2HC type
    pfam08474
    Location:474705
    MYT1; Myelin transcription factor 1

RNA

  1. XR_375392.5 RNA Sequence

  2. XR_004938798.1 RNA Sequence

  3. XR_001781155.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171680.1: Suppressed sequence

    Description
    NM_001171680.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.