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MYL6 myosin light chain 6 [ Homo sapiens (human) ]

Gene ID: 4637, updated on 5-Jul-2020

Summary

Official Symbol
MYL6provided by HGNC
Official Full Name
myosin light chain 6provided by HGNC
Primary source
HGNC:HGNC:7587
See related
Ensembl:ENSG00000092841 MIM:609931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 771.0), endometrium (RPKM 608.0) and 25 other tissues See more
Orthologs

Genomic context

See MYL6 in Genome Data Viewer
Location:
12q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56158359..56161579)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56552045..56555366)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin 1 Neighboring gene myosin light chain 6B Neighboring gene myosin light chain 6B Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 Neighboring gene tRNA-Ser (anticodon CGA) 4-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) in the nucleoli of Jurkat T-cells PubMed
tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed
Vpr vpr HIV-1 Vpr upregulates MYL6 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin-dependent ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of muscle IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
muscle filament sliding TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
brush border IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
myosin complex TAS
Traceable Author Statement
more info
PubMed 
unconventional myosin complex TAS
Traceable Author Statement
more info
PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
myosin light polypeptide 6
Names
17 kDa myosin light chain
myosin light chain A3
myosin light chain alkali 3
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029223.1 RefSeqGene

    Range
    5099..8319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021019.5NP_066299.2  myosin light polypeptide 6 isoform 1

    See identical proteins and their annotated locations for NP_066299.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), which is the major non-muscle transcript, represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    BC017455, BG283793, CA427580
    Consensus CDS
    CCDS8906.1
    UniProtKB/Swiss-Prot
    P60660
    Related
    ENSP00000446955.1, ENST00000550697.5
    Conserved Domains (1) summary
    PTZ00184
    Location:5150
    PTZ00184; calmodulin; Provisional
  2. NM_079423.4NP_524147.2  myosin light polypeptide 6 isoform 2

    See identical proteins and their annotated locations for NP_524147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) is the same length as isoform 1, but the proteins differ in their C-terminal sequences.
    Source sequence(s)
    BC093066, BG283793, CA427580
    Consensus CDS
    CCDS31834.1
    UniProtKB/Swiss-Prot
    P60660
    Related
    ENSP00000446714.1, ENST00000547649.5
    Conserved Domains (1) summary
    PTZ00184
    Location:5149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56158359..56161579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_079425.1: Suppressed sequence

    Description
    NM_079425.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein is not supported by current protein homology data.
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