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MYH9 myosin heavy chain 9 [ Homo sapiens (human) ]

Gene ID: 4627, updated on 8-Jul-2018
Official Symbol
MYH9provided by HGNC
Official Full Name
myosin heavy chain 9provided by HGNC
Primary source
HGNC:HGNC:7579
See related
Ensembl:ENSG00000100345 MIM:160775; Vega:OTTHUMG00000030429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MHA; FTNS; EPSTS; BDPLT6; DFNA17; MATINS; NMMHCA; NMHC-II-A; NMMHC-IIA
Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in spleen (RPKM 146.6), lung (RPKM 134.4) and 25 other tissues See more
Orthologs
See MYH9 in Genome Data Viewer
Location:
22q12.3
Exon count:
47
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (36281277..36388067, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36677323..36784107, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein L2 Neighboring gene uncharacterized LOC112268296 Neighboring gene apolipoprotein L1 Neighboring gene microRNA 6819 Neighboring gene uncharacterized LOC105377199 Neighboring gene ribosomal protein S15a pseudogene 38 Neighboring gene uncharacterized LOC105373018

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.
NHGRI GWA Catalog
Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA.
NHGRI GWA Catalog
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of myosin, heavy chain 9, non-muscle (MYH9) in human B cells PubMed
Nef nef MYH9 is downregulated by HIV-1 infection, which indicates that MYH9 downregulation is likely part of the Nef-mediated signaling cascade that includes RhoA downregulation PubMed
Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, heavy chain 9, non-muscle (MYH9) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat Myosin, heavy chain 9, non-muscle (MYH9, NMHC-IIA) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells PubMed
tat Expression of HIV-1 Tat upregulates the abundance of myosin, heavy chain 9, non-muscle (MYH9) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of myosin, heavy chain 9 (MYH9, non-muscle) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
retropepsin gag-pol HIV-1 protease cleaves human myosin heavy chain in vitro PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate ROCKs, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate ROCKs, organism-specific biosystemRHO associated, coiled-coil containing protein kinases ROCK1 and ROCK2 consist of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding domain and a plekstrin homology (PH) domain int...
  • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
    RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
  • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
  • RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PKNs, organism-specific biosystemProtein kinases N (PKN), also known as protein kinase C-related kinases (PKR) feature a C-terminal serine/threonine kinase domain and three RHO-binding motifs at the N-terminus. RHO GTPases RHOA, RHO...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
    Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
  • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
    Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104539

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding NAS
Non-traceable Author Statement
more info
PubMed 
actin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to actin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microfilament motor activity IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein membrane anchor IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament-based movement IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin structure organization IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokinetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of T cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of meiotic spindle localization IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
leukocyte migration NAS
Non-traceable Author Statement
more info
PubMed 
meiotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
monocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of actin filament severing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin filament severing ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet aggregation HMP PubMed 
platelet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein processing in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
uropod organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
brush border IEA
Inferred from Electronic Annotation
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
colocalizes_with focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
myosin II complex IDA
Inferred from Direct Assay
more info
PubMed 
myosin II filament IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
uropod IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myosin-9
Names
cellular myosin heavy chain, type A
myosin, heavy chain 9, non-muscle
non-muscle myosin heavy chain 9
non-muscle myosin heavy chain A
non-muscle myosin heavy chain IIa
non-muscle myosin heavy polypeptide 9
nonmuscle myosin heavy chain II-A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011884.2 RefSeqGene

    Range
    4952..111742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_567

mRNA and Protein(s)

  1. NM_002473.5NP_002464.1  myosin-9

    See identical proteins and their annotated locations for NP_002464.1

    Status: REVIEWED

    Source sequence(s)
    AA420536, AB191263, DC296130, Z82215
    Consensus CDS
    CCDS13927.1
    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Related
    ENSP00000216181.5, OTTHUMP00000165902, ENST00000216181.10, OTTHUMT00000259110
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    36281277..36388067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028806.1XP_016884295.1  myosin-9 isoform X1

    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
  2. XM_017028803.1XP_016884292.1  myosin-9 isoform X1

    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
  3. XM_017028804.1XP_016884293.1  myosin-9 isoform X1

    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
  4. XM_011530197.2XP_011528499.1  myosin-9 isoform X1

    See identical proteins and their annotated locations for XP_011528499.1

    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
  5. XM_017028805.1XP_016884294.1  myosin-9 isoform X1

    UniProtKB/Swiss-Prot
    P35579
    UniProtKB/TrEMBL
    A0A024R1N1
    Conserved Domains (3) summary
    pfam01576
    Location:8411921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:2968
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
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